冯高谦，教授，博士，博士生导师，
科学研究方向
寄生虫感染与免疫
反向疫苗学
蚊媒病疫苗开发
联系方式
通讯：江苏省南京市江宁区龙眠大道101号病原生物学系，邮编211166
电邮：fenggaoqian@njmu.edu.cn
简介
冯高谦，博士，南京医科大学教授，博士生导师。主要从事包括疟原虫在内的寄生虫感染与宿主保护性免疫机制方面的研究，以及通过反向疫苗学开发新型疫苗等工作。曾主持澳大利亚NHMRC Ideas Grant，CASS基金会Science and Medicine Grant，作为主要参与人参与多项PATH-MVI研究项目。近年来以第一作者在Nature Communications，BMC Medicine，Journal of Infectious Diseases等高水平期刊发表多篇论文。目前按照Expert Scape排名，在所有疫苗方面的全球科学家中排名前0.2%。据Web of Science检索，H指数为19。
教育背景及工作经历
2007年-2011年 澳大利亚墨尔本大学医学院 博士
2011年-2018年 澳大利亚Burnet医学研究所 Research Officer
2018年-2023年 澳大利亚Burnet医学研究所 Senior Research Officer
2023年-现在 南京医科大学病原生物系 教授
学术兼职
澳大利亚寄生虫学会 会员
世界卫生组织快速诊断试剂资格预评估专家
Frontiers in Cellular and Infection Microbiology 编委
Decoding Transmission and Infection 编委
中国寄生虫学与寄生虫病杂志青年编委
承担科研课题
1. 2020-2022 Harnessing host immunity against disease vectors 主持人 CASS Foundation
2. 2021-2022 Host immune mechanisms against disease vectors 主持人 Burnet Institute
3. 2018-2019 Understanding RTS,S immunity to inform vaccine implementation and design an improved pre-erythrocyte stage vaccine to facilitate malaria elimination 主持人 ACREME Seed Grant
4.2016-2017 Developing an effective vaccine against malaria that overcomes immune evasion 主持人 CASS Foundation
5. 2019-2022 Enhanced identification of targets of immunity to advance P. vivax vaccine development 共同主持人 Australian NHMRC Ideas Grant
代表性论文
1. Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children Feng G, Kurtovic L, Agius P, itken E, Sacarlal J,. Wines B, Hogarth P, Rogerson S, Fowkes F, Dobaño C and Beeson J BMC Med 2022
2. Mechanisms of Fc-receptor mediated immunity to malaria sporozoites. Feng, G., Wines, B. D., Kurtovic, L., Chan, J. A., Boeuf, P., Mollard, V., Cozijnsen, A., Drew, D. R., Center, R. J., Marshall, D. L., Chishimba, S., McFadden, G. I., Dent, A. E., Chelimo, K., Boyle, M. J., Kazura, J. W., Hogarth, P. M. and Beeson, J. G. Nat Commun 2021
3. Human immunization with a polymorphic malaria vaccine candidate induced antibodies to conserved epitopes that promote functional antibodies to multiple parasite strains Feng, G., M. J. Boyle, N. Cross, J. A. Chan, L. Reiling, F. Osier, D. Stanisic, I. Mueller, R. F. Anders, J. S. McCarthy, J. S. Richards, and J. G. Beeson J Infect Dis 2018
4. Targets of complement-fixing antibodies in protective immunity against malaria in children Reiling, L., M. J. Boyle, M. T. White, D. W. Wilson, G. Feng, R. Weaver, D. H. Opi, K. E. M. Persson, J. S. Richards, P. M. Siba, F. J. I. Fowkes, E. Takashima, T. Tsuboi, I. Mueller, and J. G. Beeson Nat Commun 2019
5. Induction and decay of functional complement-fixing antibodies by the RTS,S malaria vaccine in children, and a negative impact of malaria exposure Kurtovic, L., P. A. Agius, G. Feng, D. R. Drew, I. Ubillos, J. Sacarlal, J. J. Aponte, F. J. I. Fowkes, C. Dobano, and J. G. Beeson BMC Med 2019
6. Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children Kurtovic, L., M. C. Behet, G. Feng, L. Reiling, K. Chelimo, A. E. Dent, I. Mueller, J. W. Kazura, R. W. Sauerwein, F. J. I. Fowkes, and J. G. Beeson BMC Med 2018
7. CD14(hi)CD16+ monocytes phagocytose antibody- opsonised Plasmodium falciparum infected erythrocytes more efficiently than other monocyte subsets, and require CD16 and complement to do so. J Zhou, G Feng, J Beeson, PM Hogarth, SJ Rogerson, Y Yan, A Jaworowski. BMC Med. 2015
8. Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria. MJ Boyle, L Reiling, G Feng, C Langer, FH Osier, H Aspeling-Jones, YS Cheng, J Stubbs, KK Tetteh, DJ Conway, JS McCarthy, I Muller, K Marsh, RF Anders, JG Beeson. Immunity. 2015
授权专利
James Beeson; Gaoqian Feng ; Liriye KURTOVIC ; Immunogenic compositions, 2022-2-10, WIPO, WO2022027107A1
