教师简介

卢春

作者:基础医学院 日期:2015-10-26 点击:19197


卢春 教授,理学博士,博士生导师

科学研究方向

        1、医学病毒学

        2、感染、肿瘤与表观修饰调控

联系方式

通讯:江苏省南京市江宁区龙眠大道101号学海楼B507,邮编211166

电话:025-86869399

电邮:clu@njmu.edu.cn


简介

卢春,二级教授,南京医科大学天元特聘教授,博士生导师。教育部新世纪优秀人才支持计划入选者,霍英东青年基金获得者,江苏省“333工程”第二层次培养对象,江苏省高校“青蓝工程”中青年学术带头人,江苏省“六大人才高峰”建设优秀人才,第九届江苏省优秀青年科技奖获得者、江苏省优秀博士学位论文”指导老师。目前担任中华医学会病毒学分会常委、江苏省微生物学会理事长、SCI收录期刊J Med Virol杂志副主编。先后主持国家自然科学基金重点项目,国家自然科学基金——美国国立卫生研究院(NSFC-NIH)重点国际合作项目(2项)、国家自然科学基金专项项目等。以通讯作者身份在Nat CommunPNASNucleic Acids ResCell Death DifferPLoS PathogOncogeneJ Virol等权威期刊上发表SCI论文50余篇。主编及参编专著7部,获省级以上奖励三次,获国家授权发明专利5项。


教育背景及工作经历

1994-1997  南京农业大学获理学博士学位

2000-2002  美国芝加哥Loyola大学微生物学系博士后研究

1997-2000  南京医科大学讲师

2000-2005  南京医科大学副教授

2005-至今   南京医科大学教授

 

奖项及荣誉

2019/2018/2008 “江苏省优秀博士学位论文”指导老师

2008 江苏省六大人才高峰五年建设优秀人才

2006 第九届江苏省青年科技奖

2006 教育部新世纪优秀人才支持计划入选者

2006 霍英东青年教师基金获得者

2003 江苏省“333工程第二层次培养对象

2003 江苏省高校青蓝工程中青年学术带头人

 

学术兼职

1、SCI收录期刊J Med Virol(《医学病毒学》)杂志副主编

2、中华医学会医学病毒学分会常务委员

3、江苏省微生物学会理事长

4、中国微生物学会病毒学专委会委员

5、中国微生物学会微生物与免疫学专委会委员

6、中国微生物学会理事

 

承担科研课题

1、         国家自然科学基金专项项目,N-乙酰基转移酶10NAT10)新型翻译后修饰介导RNA乙酰化调控猴痘病毒(MPXV)复制与分子机制研究(82241067),主持人。

2、         国家自然科学基金重点项目,长链非编码RNAlncRNAs)调控KSHV诱导内皮细胞迁移侵袭与血管生成及其分子机制研究(81730062),主持人。

3、         国家自然科学基金——美国国立卫生研究院(NSFC-NIH)重点国际合作项目,KSHV microRNAs促进血管生成与肿瘤侵袭及其分子机制的研究(81761128003),主持人。

4、         国家自然科学基金——美国国立卫生研究院(NSFC-NIH)重点国际合作项目,卡波氏肉瘤病毒(KSHV)编码的microRNAs在细胞转化和肿瘤形成中的作用(81361120387),主持人。

 

代表性论文(均为通讯作者)、专利

1.     Li W, Zhou J, Gu Y, Chen Y, Huang Y, Yang J, Zhu X, Zhao K, Yan Q, Zhao Z, Li X*, Chen G*, Jia X*, Gao SJ, Lu C*. Lactylation of RNA m6A demethylase ALKBH5 promotes innate immune response to DNA herpesviruses and mpox virus. Proc Natl Acad Sci U S A. 2024 Oct 22;121(43):e2409132121.

2.     Yan Q*, Zhou J, Gu Y, Huang W, Ruan M, Zhang H, Wang T, Wei P, Chen G*, Li W*, Lu C*. Lactylation of NAT10 promotes N4-acetylcytidine modification on tRNASer-CGA-1-1 to boost oncogenic DNA virus KSHV reactivation. Cell Death Differ. 2024 Oct;31(10):1362-1374.

3.     Zhou J, Wang T, Zhang H, Liu J, Wei P, Xu R, Yan Q*, Chen G*, Li W*, Gao SJ, Lu C*. KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation. PLoS Pathog. 2024 Mar 12;20(3):e1012082.

4.     Yan Q, Zhou J, Wang Z, Ding X, Ma X, Li W, Jia X*, Gao SJ, Lu C*. NAT10-dependent N4-acetylcytidine modification mediates PAN RNA stability, KSHV reactivation, and IFI16-related inflammasome activation. Nat Commun. 2023 Oct 10;14(1):6327.

5.     Shi J, Jia X, He Y, Ma X, Qi X, Li W, Gao SJ, Yan Q*Lu C*. Immune evasion strategy involving propionylation by the KSHV interferon regulatory factor 1 (vIRF1). PLoS Pathog. 2023 Apr 6;19(4):e1011324.

6.     Qi X, Yan Q, Shang Y, Zhao R, Ding X, Gao SJ, Li W*, Lu C*. A viral interferon regulatory factor degrades RNA-binding protein hnRNP Q1 to enhance aerobic glycolysis via recruiting E3 ubiquitin ligase KLHL3 and decaying GDPD1 mRNA. Cell Death Differ. 2022 Nov;29(11):2233-2246.

7.     Yao S, Jia X, Wang F, Sheng L, Song P, Cao Y, Shi H, Fan W*, Ding X*, Gao SJ, Lu C*. CircRNA ARFGEF1 functions as a ceRNA to promote oncogenic KSHV-encoded viral interferon regulatory factor induction of cell invasion and angiogenesis by upregulating glutaredoxin 3. PLoS Pathog. 2021 Feb 4;17(2):e1009294.

8.     Li W, Wang F, Shi J, Feng Q, Chen Y, Qi X, Wang C, Lu H, Lu Z, Jia X, Yan Q, Gao SJ, Lu C*. Sperm associated antigen 9 promotes oncogenic KSHV-encoded interferon regulatory factor-induced cellular transformation and angiogenesis by activating the JNK/VEGFA pathway. PLoS Pathog. 2020 Aug 10;16(8):e1008730.

9.     Li W, Wang Q, Qi X, Lu H, Chen Y, Shi J, Wang F, Wang Z, Lu Z, Yan Q, Wang C*, Gao SJ, Lu C*. An oncogenic viral interferon regulatory factor upregulates CUB domain-containing protein 1 to promote angiogenesis by hijacking transcription factor lymphoid enhancer-binding factor 1 and metastasis suppressor CD82. Cell Death Differ. 2020 Dec;27(12):3289-3306.

10.  Li W, Wang Q, Qi X, Guo Y, Lu H, Chen Y, Lu Z, Yan Q, Zhu X*, Jung JU, Tosato G, Gao SJ, Lu C*. Viral interleukin-6 encoded by an oncogenic virus promotes angiogenesis and cellular transformation by enhancing STAT3-mediated epigenetic silencing of caveolin 1. Oncogene.2020 Jun;39(23):4603-4618.

11.  Ding X, Xu J, Wang C, Feng Q, Wang Q, Yang Y, Lu H, Wang F, Zhu K, Li W, Yan Q, Gao SJ, Lu C*. Suppression of the SAP18/HDAC1 complex by targeting TRIM56 and Nanog is essential for oncogenic viral FLICE-inhibitory protein-induced acetylation of p65/RelA, NF-κB activation, and promotion of cell invasion and angiogenesis. Cell Death Differ. 2019 Oct;26(10):1970-1986.

12.  Li W, Wang Q, Feng Q, Wang F, Yan Q, Gao SJ, Lu C*. Oncogenic KSHV-encoded interferon regulatory factor upregulates HMGB2 and CMPK1 expression to promote cell invasion by disrupting a complex lncRNA-OIP5-AS1/miR-218-5p network. PLoS Pathog. 2019 Jan 30;15(1):e1007578.

13.  Ding X, Jia X, Wang C, Xu J, Gao SJ, Lu C*. A DHX9-lncRNA-MDM2 interaction regulates cell invasion and angiogenesis of cervical cancer. Cell Death Differ. 2019 Sep;26(9):1750-1765.

14.  Yan Q, Zhao R, Shen C, Wang F, Li W, Gao SJ, Lu C*. Upregulation of miR-711 mediates HIV-1 Vpr promotion of KSHV latency and induction of pro-proliferative/survival cytokines by targeting the Notch/NF-κB signaling axis. J Virol. 2018; 92(18). pii: e00580-18.

15.  Li W, Hu M, Wang C, Lu H, Chen F, Xu J, Shang Y, Wang F, Qin J, Yan Q, Krueger B J, Renne R, Gao SJ, Lu C*. A viral microRNA downregulates metastasis suppressor CD82 and induces cell invasion and angiogenesis by activating the c-Met signaling. Oncogene. 2017; 36(38):5407-5420.

16.  Qin J, Li W, Gao SJ, Lu C*. KSHV microRNAs: Tricks of the devil. Trends Microbiol. 2017; 25(8):648-661.

17.  Yan Q, Shen C, Qin J, Li W, Hu M, Lu H, Qin D, Zhu J, Gao SJ, Lu C*. HIV-1 Vpr inhibits Kaposi's sarcoma-associated herpesvirus lytic replication by inducing miR-942-5p and activating NF-κB signaling. J Virol. 2016; 90(19):8739-53.

18.  Li W, Yan Q, Ding X, Shen C, Hu M, Zhu Y, Qin D, Lu H, Krueger BJ, Renne R, Gao SJ, Lu C*. The SH3BGR/STAT3 pathway regulates cell migration and angiogenesis induced by a gammaherpesvirus microRNA. PLoS Pathog. 2016; 12(4):e1005605.

19.  Yao S, Hu M, Hao T, Li W, Xue X, Xue M, Zhu X, Zhou F, Qin D, Yan Q*, Zhu J, Gao SJ, Lu C*. MiRNA-891a-5p mediates HIV-1 Tat and KSHV Orf-K1 synergistic induction of angiogenesis by activating NF-κB signaling. Nucleic Acids Res. 2015; 43(19):9362-78.

20.  Hu M, Wang C, Li W, Lu W, Bai Z, Qin D, Yan Q*, Zhu J, Krueger BJ, Renne R, Gao SJ, Lu C*. A KSHV microRNA directly targets G protein-coupled receptor kinase 2 to promote the migration and invasion of endothelial cells by inducing CXCR2 and activating AKT signaling. PLoS Pathog. 2015; 11(9):e1005171.

21.  Xue M, Yao S, Hu M, Li W, Hao T, Zhou F, Zhu X, Lu H, Qin D, Yan Q*, Zhu J, Gao SJ, Lu C*. HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway. Nucleic Acids Res. 2014; 42(15):9862-9879.

22.  Zhu X, Guo Y, Yao S, Yan Q, Xue M, Hao T, Zhou F, Zhu J, Qin D*, Lu C*. Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway. Oncogene. 2014; 33(15):1986-1996.

23.  Yan Q, Ma X, Shen C, Cao X, Feng N, Qin D, Zeng Y, Zhu J, Gao S, Lu C*. Inhibition of Kaposi’s sarcoma-associated herpesvirus lytic replication by HIV-1 Nef and cellular microRNA hsa-miR-1258. J Virol. 2014; 88(9):4987-5000.

24.  Bai Z, Huang Y, Li W, Zhu Y, Jung JU, Lu C*, Gao SJ*. Genomewide mapping and screening of Kaposi's sarcoma-associated herpesvirus (KSHV) 3'untranslated regions identify bicistronic and polycistronic viral transcripts as frequent targets of KSHV microRNAs. J Virol. 2014; 88(1):377-392.

25.  一种人-Sin3相关多肽P18过表达质粒的构建方法及其应用。国家发明专利号:ZL201811031238.5。李婉,卢春

26.  一种长链非编码RNA lncRNA-6585及其抗体与应用。国家发明专利号:ZL201811239545.2。李婉,卢春



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