顾丹灵，副教授，博士
科学研究方向
肿瘤干细胞微环境调控和干预策略
联系方式
通讯：江苏省南京市江宁区龙眠大道101号细胞生物学系，邮编211166
电邮：gudanling@njmu.edu.cn
简介
南京医科大学细胞生物学系副教授，医学博士。主要从事肿瘤干细胞微环境调控和干预策略研究，以第一或通讯作者在Cancer Cell（2025）、Developmental Cell（2025）、Science Translational Medicine（2024）、Neuro-Oncology（2023）、Clinical Cancer Research（2023）、Nature Communications（2024）、Cancer Letters（2026）等杂志上发表论文，授权国家发明专利2项。主持国家自然科学基金青年项目和中国博士后科学基金面上项目等科研项目，并入选“江苏省卓越博士后”计划。
承担科研课题
1. 国家自然科学基金委员会青年项目，82403427，肿瘤浸润浆细胞通过IgG-FcγRIIB介导巨噬细胞免疫抑制表型在胶质母细胞瘤恶性进展中的功能和机制研究，2025-01-01至2027-12-31，30万元，在研，主持。
2. 中国博士后科学基金第74批面上资助项目，2023M741795，肿瘤浸润浆细胞通过IgG-FcγRIIA-AKT-mTOR轴促进胶质母细胞瘤恶性演进的机制研究，2024-01-01至2025-07-31，8万元，结题，主持。
代表性论文
1. Hui Huang#, Chenhua Li#, Hao You#, Zhen Zhang#, Qiankun Lin, Junlei Yang, Hang Yu, Zhiting Li, Gaoyuan Cui, Kefan Song, Qian Zhang, Yun Chen, Xiuxing Wang, Junxia Zhang*, Danling Gu*, Chao Cheng*, Junfei Shao*. Radiation-induced glioblastoma stem cell-mediated T cell exhaustion via EGR1-Gal3-LAG3 axis in glioblastoma. Cancer Letters 2026 Jan 1:636:218125. IF: 10.1. 中科院一区.
2. Danling Gu#, Lang Hu#, Kailing Yang#, Wei Yuan#, Danyang Shan#, Jiancheng Gao#, Jiahuang Li, Ryan C. Gimple, Deobrat Dixit, Zhe Zhu, Daqi Li, Qiulian Wu, Zhumei Shi, Yingyi Wang, Ningwei Zhao, Kun Yang, Junfei Shao, Fan Lin, Qianghu Wang, Guangfu Jin, Yun Chen, Xu Qian, Zhibin Hu, Chaojun Li, Nu Zhang, Yongping You, Jian Liu*, Qian Zhang*, Junxia Zhang*, Jeremy N. Rich*, Xiuxing Wang*. Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages. Developmental Cell2025 Oct 6;60(19):2558-2575. IF: 10.7. 中科院一区.
3. Jiancheng Gao#, Danling Gu#, Kailin Yang#, Junxia Zhang#, Qiankun Lin#, Wei Yuan#, Xu Zhu#, Deobrat Dixit, Ryan C. Gimple, Hao You, Qian Zhang, Zhumei Shi, Xiao Fan, Qiulian Wu, Chenfei Lu, Zhangchun Cheng, Daqi Li, Linjie Zhao, Bin Xue, Zhu Zhu, Zhe Zhu, Hui Yang, Ningwei Zhao, Wei Gao, Yingmei Lu, Junfei Shao, Chuandong Cheng, Dapeng Hao, Shuo Yang, Yun Chen, Xiaoming Wang, Chunsheng Kang, Jing Ji, Jianghong Man, Sameer Agnihotri,Qianghu Wang, Fan Lin, Xu Qian, Stephen C. Mack, Zhibin Hu, Chaojun Li, Michael D. Taylor, Yan Li*, Nu Zhang*, Jeremy N. Rich*, Yongping You*, Xiuxing Wang*. Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding. Cancer Cell2025 Jan 13;43(1):122-143.e8. IF: 48.8. 中科院一区.
4. Danling Gu#, Fengqi Zhou#, Hao You#, Jiancheng Gao#, Tao Kang, Deobrat Dixit, Qiulian Wu, Kailin Yang, Shusheng Ci, Danyang Shan, Xiao Fan, Wei Yuan, Qian Zhang, Chenfei Lu, Daqi Li, Ningwei Zhao, Zhumei Shi, Wei Gao, Fan Lin, Jianghong Man, Qianghu Wang, Xu Qian, Stephen C Mack, Weiwei Tao, Sameer Agnihotri, Nu Zhang, Yongping You, Jeremy N Rich*, Junxia Zhang*, Xiuxing Wang*. Sterol regulatory element-binding protein 2 maintains glioblastoma stem cells by keeping the balance between cholesterol biosynthesis and uptake. Neuro-Oncology2023 Sep 5;25(9):1578-1591. IF: 15.9. 中科院一区.
5. Danling Gu#, Hao You#, Jiancheng Gao#, Yongping You, Jeremy N Rich*, Junxia Zhang*, Xiuxing Wang*. Reply to “Targeting cholesterol homeostasis through inhibiting: An Achilles’ heel for glioblastoma?”.Neuro-Oncology 2023 Nov 2;25(11):2103-2104. IF: 15.9. 中科院一区.
6. Danling Gu#, Hanning Tang#, Jiazhu Wu, Jianyong Li* and Yi Miao*. Targeting Bruton tyrosine kinase using non-covalent inhibitors in B cell malignancies. Journal of Hematology & Oncology2021 Mar 6;14(1):40. IF: 23.1. 中科院一区.
7. Wei Yuan#, Qian Zhang#, Danling Gu#, Chenfei Lu#, Deobrat Dixit, Ryan C. Gimple, Yisu Gao, Jiancheng Gao, Daqi Li, Danyang Shan, Lang Hu, Lu Li, Yangqing Li, Shusheng Ci, Hao You, Linping Yan, Kexin Chen, Ningwei Zhao, Chuanhai Xu, Jianyun Lan, Dong Liu, Junxia Zhang, Zhumei Shi, Qiulian Wu, Kailin Yang, Linjie Zhao, Zhixin Qiu,, Deguang Lv, Wei Gao, Hui Yang, Fan Lin, Qianghu Wang, Jianghong Man, Chaojun Li, Weiwei Tao, Sameer Agnihotri, Xu Qian, Stephen C. Mack, Nu Zhang, Yongping You, Jeremy N. Rich*, Guan Sun*, Xiuxing Wang*. Dual role of CXCL8 in maintaining the mesenchymal state of glioblastoma stem cells and M2-like tumor-associated macrophages. Clinical Cancer Research 2023 Sep 15;29(18):3779-3792. IF: 13.8. 中科院一区.
8. Fanying Li#, Kailin Yang#, Xinya Gao#, Maolei Zhang#, Danling Gu#, Xujia Wu, Chenfei Lu, Qiulian Wu, Deobrat Dixit, Ryan C. Gimple, Yongping You, Stephen C. Mack, Yu Shi, Tiebang Kang, Sameer A. Agnihotri, Michael D. Taylor, Jeremy N. Rich*, Nu Zhang*, Xiuxing Wang*. A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice. Science Translational Medicine 2024 Oct 2;16(767):eadk9524. IF: 19.3. 中科院一区.
9. Handong Sun#, Lishen Zhang#, Zhonglin Wang#, Danling Gu#, Mengyan Zhu, Yun Cai, Lu Li, Jiaqi Tang, Bin Huang, Bakwatanisa Bosco, Ning Li, Lingxiang Wu, Wei Wu, Liangyu Li, Yuan Liang, Lin Luo, Quanzhong Liu, Yanhui Zhu, Jie Sun, Liang Shi, Tiansong Xia, Chuang Yang, Qitong Xu, Xue Han, Weiming Zhang, Jianxia Liu, Dong Meng, Hua Shao, Xiangxin Zheng, Shuqin Li, Hua Pan, Jing Ke, Wenying Jiang, Xiaolan Zhang, Xuedong Han, Jian Chu, Hongyin An, Juyan Ge, Chi Pan, Xiuxing Wang, Kening Li*, Qianghu Wang*, Qiang Ding*. Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer. Nature Communications2023 Sep 11;14(1):5590. IF: 17.7. 中科院一区.
