教师简介

陈芳

作者:基础医学院 日期:2020-05-13 点击:8822

陈芳 教授 博士 博士生导师

科学研究方向

糖尿病发病机制与治疗

联系方式

通讯:江苏省南京市江宁区龙眠大道101号生物化学与分子生物学系,邮编211166

电话:025-86869423(建议填办公电话)

电邮:chenfang@njmu.edu.cn


简介

陈芳,女,毕业于南京医科大学,长期从事糖尿病发病机制的研究,关注胰岛功能异常在糖尿病发生发展中的作用;筛选靶向纠正胰岛功能进行糖尿病治疗的药物。先后主持国家自然基金4项;参与国自然重点、国自然国际(地区)合作与交流、973课题等10余项;近10年以通讯或第一作者身份在包括AutophagyDiabetesDiabetologiaSCI收录专业期刊发表论文10余篇。

 

教育背景及工作经历

教育背景:

1994.91999.7, 南京医科大学, 预防医学, 学士

2004.92007.7, 南京医科大学, 免疫学, 硕士研究生

2007.92010.12, 南京医科大学,生物化学与分子生物学, 博士研究生

工作经历:

1999.82004.8, 江苏职工医科大学,基础部形态学系,助教

2011.9-2016.6, 南京医科大学, 基础医学院, 讲师

2016.7-2022.7, 南京医科大学, 基础医学院, 副教授

2022.7-至今, 南京医科大学, 基础医学院, 教授

 

承担科研课题

1. 国家自然科学基金青年科学基金项目:E3 泛素连接酶 Synoviolin 对胰岛β细胞功能的影响,项目批准号81200558,经费23万,起止时间 2013.01-2015.12,结题,主持;

2. 国家自然科学基金面上项目:SCD12 型糖尿病中对胰岛β细胞功能的保护作用及机制研究,项目批准号81670705,经费62万,起止时间 2017.01-2020.12,结题,主持;

3. 国家自然科学基金面上项目:SCD1改善糖尿病胰岛α细胞功能失调及机制研究,项目批准号81970673,经费55万,起止时间 2020.01-2023.12,在研,主持;

4. 国家自然科学基金面上项目:SCD1诱导胰岛α细胞转分化为β细胞改善糖尿病及机制研究,项目批准号82170810,经费55万,起止时间 2022.01-2025.12,在研,主持;

5. 国家自然科学基金重点项目: ETS-1在糖尿病胰岛beta细胞功能障碍中的作用研究,项目批准号81300638,经费260万,起止时间 2012.01-2016.12,结题,参与;

6. 国家自然科学基金委员会国际(地区)合作与交流项目:SAD-A介导的mTORC1信号在代谢性疾病中调控胰岛β细胞功能和数量的作用,项目批准号81420108007,经费300万,起止时间 2015.01-2019.12,结题,参与;

7. 国家自然科学基金重点项目: E转录因子Ets-1介导2型糖尿病胰岛β细胞去分化与转分化的作用与机制研究,项目批准号81830024,经费294万,起止时间2019.01-2023.12,在研,参与;

8. 国家自然科学基金面上项目:E3泛素连接酶Hrd1ox-LDL所致血管内皮细胞损伤中的作用与机制研究,项目批准号81670421,经费57万,起止时间 2017.01-2020.12,结题,参与;

9. 江苏省科技厅优秀青年基金项目:微囊泡在代谢疾病中的作用机制及应用研究,项目批准号BK20170106,经费50万,起止时间 2017.07-2020.06,结题,参与;

10. 江苏省科技厅青年基金项目:鉴定在乳腺癌细胞中调控Twist1的蛋白磷酸酶及其机制和功能研究,项目批准号BK20171056,经费20万,起止时间 2017.07-2020.06,结题,参与。

 

代表性论文

1. Yixue Shao#, Yuhan Zhang, Suyun Zou, Jianan Wang, Xirui Li, Miaozhen Qin, Liangjun Sun, Wenyue Yin, Xiaoai Chang, Shusen Wang, Xiao Han*, Tijun Wu*, Fang Chen*. (-)-Epigallocatechin 3-gallate protects pancreatic β-cell against excessive autophagy-induced injury through promoting FTO degradation. Autophagy. 2024 Jul 3:1-18.(主要通讯作者)

2. Honglei Yuan#, Mei He, Qinnan Yang, Fandi Niu, Yuchen Zou, Chen Liu, Yang Yang, Aiming Liu, Xiaoai Chang, Fang Chen*, Tijun Wu*, Xiao Han*, Yaqin Zhang*. Obesity-induced upregulation of miR-483-5p impairs the function and identity of pancreatic β-cells. Diabetes Obes Metab. 2024 Jul 29.(共同通讯作者)

3. Xue Zhang#, Dan Zhang#, Lei Huo, Xin Zhou, Jia Zhang, Min Li, Dongming Su, Peng Sun, Fang Chen*, Xiubin Liang*. Upregulation of α-ENaC induces pancreatic β-cell dysfunction, ER stress, and SIRT2 degradation. J Biomed Res. 2024 May 21; 38(3): 241-255. (共同通讯作者)

4. Tijun Wu #, Yixue Shao, Xirui Li, Tao Wu, Ling Yu, Jin Liang, Yaru Zhang, Jiahui Wang, Tong Sun, Yunxia Zhu, Xiaoai Chang, Shusen Wang, Fang Chen*, and Xiao Han*. NR3C1/Glucocorticoid receptor activation promotes pancreatic β-cell autophagy overload in response to glucolipotoxicity. Autophagy. 2023; 19(9): 2538-2557.(共同通讯作者)

5. Kaini Zhang #, Chen Yang #, Xin Zhou #, Jin Liang, Jianjin Guo, Min Li, Yi Zhang, Shulin Shao, Peng Sun, Kai Li, Jingjing Huang, Fang Chen*, Xiubin Liang* and Dongming Su*. TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN. Cell Mol Life Sci. 2023; 80(6): 168.(共同通讯作者)

6. Tijun Wu, Jiahui Wang, Yaru Zhang, Yixue Shao, Xirui Li, Yuqing Guo, Wenyu Dong, Lin Wang, Fang Chen*, and Xiao Han*. Lentinan protects against pancreatic beta-cell failure in chronic ethanol consumption-induced diabetic mice via enhancing beta-cell antioxidant capacity. Journal of Cellular and Molecular Medicine. 2021; 25(13): 6161-6173. (共同通讯作者)

7. Xiaoying You#, Min Li#, Hongwei Cai#, Wenwen Zhang#, Ye Hong, Wenjie Gao, Yun Liu, Xiubin Liang, Tijun Wu*, Fang Chen*, and Dongming Su*. Calcium binding protein S100A16 expedites proliferation, invasion and epithelial-mesenchymal transition process in gastric cancer. Frontiers in Cell and Developmental Biology. 2021; 9: 736929. (共同通讯作者)

8. Tijun Wu#, Shuang Zhang, Jialiang Xu, Yaqin Zhang, Tong Sun, Yixue Shao, Jiahui Wang, Wei Tang, Fang Chen*, and Xiao Han*. HRD1, an important player in pancreatic β-cell failure and therapeutic target for type 2 diabetic mice. Diabetes. 2020; 69(5): 940-953.(共同通讯作者)

9. Yaqin Zhang, Hongliang Mei, Wei Shan, Li Shi, Xiaoai Chang, Yunxia Zhu, Fang Chen* and Xiao Han*. J Cell Mol Med. 2016; 20(10): 1803-1812.(共同通讯作者)

10. Tijun Wu#, Jie Xiang#, Wei Shan, Mengxiao Li, Wenbo Zhou, Xiao Han and Fang Chen*. Epigallocatechin-3-Gallate Inhibits Ethanol-Induced Apoptosis Through Neurod1 Regulating CHOP Expression in Pancreatic β Cells. The Anatomical Record. 2016; 299:573-582. (通讯作者)

11. Fang Chen#, Min Sha, Yanyang Wang, Tijun Wu, Wei Shan, Jia Liu, Wenbo Zhou, Yunxia Zhu, Yujie Sun, Yuguang Shi, David Bleich and Xiao Han*. Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models. Diabetologia. 2016: 59:316-324.(第一作者)

12. Fang Chen#, Jia Liu, Yanyang Wang, Tijun Wu, Wei Shan, Yunxia Zhu, and Xiao Han*. Aldosterone induces clonal β-cell failure through glucocorticoid receptor. Sci Rep. 2015; 5: 13215.(第一作者)

13. Yaqin Zhang#, Bin Qian, Yangyang, Fandi Niu, Changsong Lin, Honglei Yuan, Jianan Wang, Tijun Wu, Yixue Shao, Shulin Shao, Aiming Liu, Jingwen Wu, Peng Sun, Xiaoai Chang, Yan Bi, Wei Tang, Yunxia Zhu, Fang Chen, Dongming Su*, Xiao Han*. Visceral adipocyte-derived extracellular vesicle miR-27a-5p elicits glucose intolerance by inhibiting pancreatic β-cell insulin secretion. Diabetes. 2024 Aug 21:db240177.(其他作者)

14. Xin Zhou#, Kaini Zhang#, Chen Wang#, Yunfei Teng#, Peihong Yu#, Wei Cai, Wenjie Gao, Min Li, Ying Ding, Peng Sun, Fang Chen, Yipin Wang, Juan Ma, Noriaki Maeshige, Xiaoqi Ma , Qingguo Li*, Xiubin Liang*, Yaqin Zhang*, and Dongming Su*. Isthmin-1 promotes growth and progression of colorectal cancer through the interaction with EGFR and YBX-1. Cancer Lett. 2024; 590: 216868.(其他作者)

15. Tijun Wu# , Zhi Cai# , Fandi Niu# , Bin Qian, Peng Sun, Nan Yang, Jing Pang, Hongliang Mei, Xiaoai Chang, Fang Chen, Yunxia Zhu, Yating Li, Fugen Wu, Yaqin Zhang*, Ting Lei*, and Xiao Han*. Nutr Diabetes. 2023; 13(1): 4. (其他作者)

16. Bin Qian#, Yang Yang; Ningyuan Tang, Jiahui Wang, Peng Sun, Nan Yang, Fang Chen, Tijun Wu, Tong Sun, Yating Li, Xiaoai Chang, Yunxia Zhu, Yaqin Zhang*, and Xiao Han*. M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt/GSK-3 beta/beta-catenin pathway in mice. Diabetologia. 2021; 64(9): 2037-2051.(其他作者)

17. Muhan Jing#, Shanshan Wang#, Ding Li#, Zeyu Wang, Ziwen Li, Yichen Lu, Tong Sun, Chen Qiu, Fang Chen, Haijuan Yu*, and Wei Zhang*. Lorcaserin Inhibit Glucose-Stimulated Insulin Secretion and Calcium Influx in Murine Pancreatic Islets. Front Pharmacol. 2021; 12: 761966.(其他作者)

18. Kai Li #; Chen Qiu#; Peng Sun #; Dechen Liu, Tijun Wu, Kai Wang, Yuncai Zhou, Xiaoai Chang, Ye Yin, Fang Chen, Yunxia Zhu, and Xiao Han*. Ets1-Mediated Acetylation of FoxO1 Is Critical for Gluconeogenesis Regulation during Feed-Fast Cycles. Cell Reports. 2019; 26(11): 2998-3010.(其他作者)

19. Xianye Cheng#, Wen Qian#, Fang Chen, Yi Jin, Fengdi Wang, Xiaoyi Lu, Sae Rom Lee, Dongming Su, and Bin Chen*. ATRA protects skin fibroblasts against UV-induced oxidative damage through inhibition of E3 ligase Hrd1. Mol Med Rep. 2019; 20(3): 2294-2302.(其他作者)

20. Hongdong Wang#, Xiaping Wang, Yunxia Zhu, Fang Chen, Yujie, Sun, and Xiao Han*. Increased androgen levels in rats impair glucose-stimulated insulin secretion through disruption of pancreatic beta cell mitochondrial function. J Steroid Biochem Mol Biol. 2015; 154: 254-266.

21. Qian Wang, Ning Wang, Mei Dong, Fang Chen, Zhong Li, Yuanyuan Chen*. GdCl3 reduces hyperglycaemia through Akt/FoxO1-induced suppression of hepatic gluconeogenesis in Type 2 diabetic mice. Clin Sci (Lond). 2014; 127(2): 91-100.

 

授权专利

1. 张亚琴; 韩晓; 邵翌雪; 杨洋; 陈芳; 常晓嫒; 牛凡弟; 刘爱民 ; 检测胰岛β细胞去分化的标志物的用途, 2023-10-31, 中国, ZL 2022 1 0322788.2

2. 张亚琴; 韩晓; 常晓嫒; 陈芳; 朱云霞; 梅洪梁; 吴倜珺; 张爽 ; 香菇多糖在制备抑制胰岛β细胞受损的药物中的用途, 2018-3-30, 中国, ZL 2016 1 1091539.8

 

获奖

1. 胰岛β细胞功能相关分子的鉴定及作用机制研究, 中华人民共和国教育部, 自然科学, 省部二等奖, 2017(韩晓; 朱云霞; 尹业; 陈芳; 林海燕)

2. 2型糖尿病胰岛β细胞损伤的分子机制研究, 江苏省人民政府, 科技进步, 省部二等奖,2017(韩晓; 史裕光; 朱云霞; 林海燕; 尹业; 陈芳; 聂佳; 孟卓贤)

3. 内质网应激导致2型糖尿病胰岛β细胞功能障碍的分子机制, 江苏省教育厅, 其他, 其他,2016(林海燕; 朱云霞; 陈芳; 尹业; 孟卓贤)


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