汪秀星，教授，博士，博士生导师，细胞生物学系科研副主任
科学研究方向
胶质瘤干细胞及其微环境调控
联系方式
通讯：江苏省南京市江宁区龙眠大道101号细胞生物学系，邮编211166
电话：025-86869340
电邮：xiuxingwang@njmu.edu.cn
简介
汪秀星，教授，博士，博士生导师。国家自然科学基金青年科学基金A类[原国家杰出青年科学基金]获得者，国家级海外高层次青年人才，江苏省特聘教授。中国神经科学学会神经肿瘤分会常务理事、中国细胞生物学学会肿瘤细胞生物学分会委员、中国抗癌协会低氧肿瘤学专委会常务委员、中国抗癌协会肿瘤节律专委会委员、中国细胞生物学会医学细胞生物学分会委员、中国医师协会脑胶质瘤专业委员会基础与转化委员。南京医科大学基础医学院细胞生物学系/国家卫生健康委员会抗体技术重点实验室教授。主要从事免疫微环境组分维持胶质瘤干细胞自我更新的功能和机制研究，为胶质母细胞瘤临床治疗提供新策略和干预靶点。以最后通讯作者在Cancer Cell (2025)、Science Translational Medicine (2024a)、Developmental Cell (2025)、Nature Communications (2025)、Cell Death & Differentiation (2024)、Clinical Cancer Research (2023)、Neuro-Oncology (2023a, 2023b)、Cancer Research (2022)上发表论文。同时以共同通讯在Cancer Discovery (2021)、Science Translational Medicine (2024b)、Nature Communications (2022, 2023)、Cancer Letters (2023)上发表论文
学术兼职
中国神经科学学会神经肿瘤分会常务委员
中国细胞生物学会肿瘤细胞生物学分会委员
中国细胞生物学会医学细胞生物学会委员
中国医师协会脑胶质瘤专业委员会基础与转化委员
江苏省细胞与发育生物学会理事
承担科研课题
1. 国家自然科学基金青年科学基金A类项目[原国家杰出青年科学基金]，胶质瘤干细胞自我更新机制与干预策略（82525047），2026-2030，在研，主持
2. 肿瘤干细胞微环境“国家级高层次青年人才”2020-2023，主持
3. 肿瘤干细胞微环境“江苏省特聘教授” 2020-2023，主持
4. 国家自然基金面上项目， CXCL8和C1ORF61对胶质母细胞瘤异质性调控机制及联合靶向治疗的研究 （81570499），2021-2024，在研，主持
5. 肿瘤个体化医学省部共建协同创新中心恒瑞医药临床研究基金，TNFAIP6维持胶质瘤干细胞炎性压力下重塑微环境的机制研究，2024/10-2026/09，在研，主持
代表性论文
通讯作者（含共同通讯作者）15篇：
1. Jiancheng Gao#, Danling Gu#, Kailin Yang#, Junxia Zhang#, Qiankun Lin#, Wei Yuan#, Xu Zhu#, Deobrat Dixit, Ryan C. Gimple, Hao You, Qian Zhang, Zhumei Shi, Xiao Fan, Qiulian Wu, Chenfei Lu, Zhangchun Cheng, Daqi Li, Linjie Zhao, Bin Xue, Zhu Zhu, Zhe Zhu, Hui Yang, Ningwei Zhao, Wei Gao, Yingmei Lu, Junfei Shao, Chuandong Cheng, Dapeng Hao, Shuo Yang, Yun Chen, Xiaoming Wang, Chunsheng Kang, Jing Ji, Jianghong Man, Sameer Agnihotri,Qianghu Wang, Fan Lin, Xu Qian, Stephen C. Mack, Zhibin Hu, Chaojun Li, Michael D. Taylor, Yan Li*, Nu Zhang*, Jeremy N. Rich*, Yongping You*, Xiuxing Wang*. Infiltrating Plasma Cells Maintain Glioblastoma Stem Cells through IgG-Tumor Binding. (Corresponding author, Cancer Cell). 01/2025. IF: 48.8. 中科院一区.
2. Daqi Li, Gaoyuan Cui, Kailin Yang, Chenfei Lu, Yuhan Jiang, Le Zhang, Qiulian Wu, Deobrat Dixit, Zhe Zhu, Ryan C. Gimple, Danling Gu, Jiancheng Gao, Qiankun Lin, Hang Yu, Zhumei Shi, Yun Chen, Qianghu Wang, Guangfu Jin, Fan Lin, Junfei Shao, Qigang Zhou, Chong Liu, Chaojun Li, Yongping You, Nu Zhang, Junxia Zhang*, Xu Qian*, Qian Zhang*, Jeremy N. Rich*, Xiuxing Wang*. Inhibition of macrophage-derived lactate impairs KU70 lactylation and enhances anti-tumour immunity in glioblastoma (Nature Cell Biology, Accept in Principle)
3. Fanying Li#, Kailin Yang#, Xinya Gao#, Maolei Zhang#, Danling Gu#, Xujia Wu, Chenfei Lu, Qiulian Wu, Deobrat Dixit, Ryan C. Gimple, Yongping You, Stephen C. Mack, Yu Shi, Tiebang Kang, Sameer A. Agnihotri, Michael D. Taylor, Jeremy N. Rich*, Nu Zhang*, Xiuxing Wang*. A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice. (Corresponding author, Science Translational Medicine, Cover Story) 10/2024. IF: 19.343. 中科院一区.
6. Chenfei Lu, Tao Kang, Junxia Zhang, Kailin Yang, Yang Liu, Kefan Song, Qiankun Lin, Deobrat Dixit, Ryan C. Gimple, Qian Zhang, Zhumei Shi, Xiao Fan, Qiulian Wu, Daqi Li, Danyang Shan, Jiancheng Gao, Danling Gu, Lu Li, Hao You, Yangqing Li, Linjie Zhao, Hui Yang, Ningwei Zhao, Wei Gao, Weiwei Tao, Yingmei Lu, Yun Chen, Jing Ji, Zhe Zhu, Chunsheng Kang, Jianghong Man, Sameer Agnihotr, Qianghu Wang, Fan Lin, Xu Qian, Stephen C. Mack, Zhibin Hu, Chaojun Li, Michael D Taylor, Ning Liu, Nu Zhang, Ming Lu, Wei Zhang, Jeremy Rich*, Yongping You*, Xiuxing Wang*. Combined targeting of glioblastoma heterogeneity as a novel therapeutic strategy. (Corresponding author, Nature Communications) 03/2025. IF: 14.7. 中科院一区.
7. Daqi Li #, Xiefeng Wang #, Kexin Chen #, Danyang Shan #, Gaoyuan Cui #, Wei Yuan, Qiankun Lin, Ryan C Gimple, Deobrat Dixit, Chenfei Lu, Danling Gu, Hao You, Jiancheng Gao, Yangqing Li, Tao Kang, Junlei Yang, Hang Yu, Kefan Song, Zhumei Shi, Xiao Fan, Qiulian Wu, Wei Gao, Zhe Zhu, Jianghong Man, Qianghu Wang, Fan Lin, Weiwei Tao, Stephen C Mack, Yun Chen, Junxia Zhang, Chaojun Li, Nu Zhang, Yongping You, Xu Qian, Kailin Yang*, Jeremy N Rich*, Qian Zhang*, Xiuxing Wang*. IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages. (Corresponding author, Cell Death & Differentiation)04/2024. IF: 13.3. 中科院一区.
8. Wei Yuan#, Qian Zhang#, Danling Gu#, Chenfei Lu#, Deobrat Dixit, Ryan C. Gimple, Yisu Gao, Jiancheng Gao, Daqi Li, Danyang Shan, Lang Hu, Lu Li, Yangqing Li, Hao You, Linping Yan, Kexin Chen, Ningwei Zhao, Chuanhai Xu, Jianyun Lan, Dong Liu, Junxia Zhang, Zhumei Shi, Qiulian Wu, Kailin Yang, Linjie Zhao, Zhixin Qiu,, Deguang Lv, Wei Gao, Hui Yang, Fan Lin, Qianghu Wang, Jianghong Man, Chaojun Li, Weiwei Tao, Sameer Agnihotri, Xu Qian, Stephen C. Mack, Nu Zhang, Yongping You, Jeremy N. Rich*, Guan Sun*, Xiuxing Wang*.Dual role of CXCL8 in maintaining the mesenchymal state of glioblastoma stem cells and M2-like tumor-associated macrophages. (Corresponding author, Clinical Cancer Research). 09/2023. IF: 13.801. 中科院一区.
9. Danling Gu#, Fengqi Zhou#, Hao You#, Jiancheng Gao#, Tao Kang, Deobrat Dixit, Qiulian Wu, Kailin Yang, Danyang Shan, Xiao Fan, Wei Yuan, Qian Zhang, Chenfei Lu, Daqi Li, Ningwei Zhao, Zhumei Shi, Wei Gao, Fan Lin, Jianghong Man, Qianghu Wang, Xu Qian, Stephen C Mack, Weiwei Tao, Sameer Agnihotri, Nu Zhang, Yongping You, Jeremy N Rich*, Junxia Zhang*, Xiuxing Wang*. SREBP2 maintains glioblastoma stem cells through keeping the balance between cholesterol biosynthesis and uptake. (Corresponding author, Neuro-Oncology) 03/2023. IF: 13.029. 中科院一区.
10. Daqi Li#, Qian Zhang#, Lu Li, Kexin Chen, Junlei Yang, Deobrat Dixit, Ryan C Gimple, Chenfei Lu, Lang Hu, Jiancheng Gao, Danyang Shan, Yangqing Li, Junxia Zhang, Zhumei Shi, Danling Gu, Wei Yuan, Qiulian Wu, Kailin Yang, Linjie Zhao, Zhixin Qiu, Deguang Lv, Wei Gao, Hui Yang, Fan Lin, Qianghu Wang, Jianghong Man, Chaojun Li, Weiwei Tao, Sameer Agnihotri, Xu Qian Yu Shi, Yongping You, Nu Zhang*, Jeremy N Rich*, Xiuxing Wang*.b2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-like Polarization of Tumor-Associated Macrophages. (Corresponding author, Cancer Research)09/2022; 82(18). IF: 13.312. 中科院一区.
11. Danling Gu#, Hao You#, Jiancheng Gao#, Yongping You, Jeremy N Rich*, Junxia Zhang*, Xiuxing Wang*. Reply to Targeting cholesterol homeostasis through inhibiting: An Achilles' heel for glioblastoma?. (Corresponding author, Neuro-Oncology) 08/2023. IF: 13.029. 中科院一区.
12. Jianxing Yin#, Xin Ge#, Fangshu Ding#, Liuguijie He, Keying Song, Zhumei Shi, Zehe Ge, Junxia Zhang, Jing Ji, Xiefeng Wang, Ningwei Zhao, Chuanjun Shu, Fan Lin, Qianghu Wang, Qigang Zhou, Yuandong Cao, Wentao Liu, Dan Ye, Jeremy N. Rich, Xiuxing Wang*, Yongping You*, Xu Qian*. Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly pathway. (Co-corresponding author, Science Translational Medicine) 03/2024. IF: 19.343. 中科院一区.
13. Jian Zhong#, Xujia Wu#, Yixin Gao#, Junju Chen#, Maolei Zhang, Huangkai Zhou, Jia Yang, Feizhe Xiao, Xuesong Yang, Nunu Huang, Haoyue Qi, Xiuxing Wang*, Fan Bai*, Yu Shi* & Nu Zhang*. Circular RNA encoded MET variant promotes glioblastoma tumorigenesis. (Co-corresponding author, Nature Communications) 07/2023. IF: 17.690. 中科院一区.
14. Xiao Fan#, Jintan Li#, Bin Huang#, Hongyu Lu, Chenfei Lu, Minhong Pan, Xiefeng Wang, Hongjian Zhang, Yongping You, Xiuxing Wang*, Qianghu Wang*, Junxia Zhang*. Noninvasive radiomics model reveals macrophage infiltration in glioma. (Co-corresponding author, Cancer Letters) 09/2023. IF: 9.756. 中科院一区.
15. Jian Zhong#, Xuesong Yang#, Junju Chen#, Kejun He#, Xinya Gao, Xujia Wu, Maolei Zhang, Huangkai Zhou, Feizhe Xiao, Lele An, Xiuxing Wang*, Yu Shi*, Nu Zhang*. Circular EZH2-Encoded EZH2-92aa Mediates Immune Evasion in Glioblastoma via Inhibition of Surface NKG2D Ligands. (Co-corresponding author, Nature Communications) 08/2022; 13(1). IF: 17.690. 中科院一区.
16. Daqi Li#, Gaoyuan Cui#, Kailin Yang#, Chenfei Lu#, Yuhan Jiang#, Le Zhang#, Qiulian Wu, Ryan C. Gimple, Deobrat Dixit, Danling Gu, Jiancheng Gao, Qiankun Lin, Hang Yu, Zhumei Shi, Zhe Zhu, Yun Chen, Qianghu Wang, Guangfu Jin, Fan Lin, Junfei Shao, Qigang Zhou, Chong Liu, Chaojun Li, Yongping You, Nu Zhang, Junxia Zhang*, Xu Qian*, Qian Zhang*, Jeremy N. Rich*, Xiuxing Wang*. Inhibition of Macrophage-Derived Lactate Impairs KU70 Lactylation and enhances Anti-Tumour Immunity in Glioblastoma. (Corresponding author, Nature Cell Biology) Revision.
1. Xiuxing Wang, Briana C. Prager , Qiulian Wu, Leo J. Y. Kim, Ryan C. Gimple, Yu Shi, Kailin Yang, Andrew Morton, Wenchao Zhou, Zhe Zhu,Elisabeth Anne Adanma Obara,Tyler E. Miller, Anne Song, Sisi Lai, Christopher G. Hubert, Xun Jin, Zhi Huang, Xiaoguang Fang, Deobrat Dixit, Weiwei Tao, Kui Zhai, Cong Chen, Zhen Dong, Guoxin Zhang, Stephen M. Dombrowski, Petra Hamerlik,Stephen C. Mack, Shideng Bao, Jeremy N. Rich: Reciprocal signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression. Cell Stem Cell 04/2018; 22(4). IF: 25.269. 中科院一区.
2. Xiuxing Wang#, Kailin Yang#, Qi Xie, Qiulian Wu, Stephen C Mack, Yu Shi, Leo J Y Kim, Briana C Prager, William A Flavahan, Xiaojing Liu, Meromit Singer, Christopher G Hubert, Tyler E Miller, Wenchao Zhou, Zhi Huang, Xiaoguang Fang, Aviv Regev, Mario L Suv, Tae Hyun Hwang, Jason W Locasale, Shideng Bao, Jeremy N Rich*. Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. Nature Neuroscience 03/2017; 20(5). IF: 28.771. 中科院一区.
3. Xiuxing Wang#, Kailin Yang#, Qiulian Wu, Leo J.Y. Kim, Andrew R. Morton, Ryan C. Gimple, Briana C. Prager, Yu Shi, Wenchao Zhou, Shruti Bhargava, Zhe Zhu, Li Jiang, Weiwei Tao, Zhixin Qiu, Linjie Zhao, Guoxing Zhang, Xiqing Li, Sameer Agnihotri, Paul S. Mischel, Stephen C. Mack, Shideng Bao, Jeremy N. Rich*. Targeting Pyrimidine Synthesis Accentuates Molecular Therapy Response in Glioblastoma Stem Cells. Science Translational Medicine08/2019 (Cover Story).IF: 19.343. 中科院一区.
4. Xiuxing Wang, zhi huang, Qiulian Wu, Briana C Prager, Stephen C Mack, Kailin Yang, Leo J. Y. Kim, Ryan C Gimple, Yu Shi, Sisi Lai, Qi Xie, Tyler E. Miller, Christopher G Hubert, Anne Song, Zhen Dong, Wenchao Zhou, Xiaoguang Fang, Zhe Zhu, Vaidehi Mahadev, Shideng Bao, Jeremy N. Rich* MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells. Cancer Research 07/2017; 77(18). IF: 13.312. 中科院一区.
5. Stephen C. Mack#, Irtisha Singh#, Xiuxing Wang#, Rachel Hirsch, Quilian Wu, Jean A.Bernatchez, Zhe Zhu, Ryan C. Gimple, Leo J.Y. Kim, Andrew Morton, Sisi Lai, Zhixin Qiu, Rosie Villagomez, Briana C. Prager, Kelsey C. Bertrand, Clarence Mah, Wenchao Zhou, Christine Lee, Gene H. Barnett, Michael A. Vogelbaum, Andrew E. Sloan, Lukas Chavez, Shideng Bao, Peter C. Scacheri, Jair L. Siqueira-Neto, Charles Y. Lin*, Jeremy N. Rich*. CHROMATIN LANDSCAPES REVEAL DEVELOPMENTALLY ENCODED TRANSCRIPTIONAL STATES THAT DEFINE GLIOBLASTOMA. Journal of Experimental Medicine, 04/2019. Co-first author. IF: 17.579. 中科院一区.
6. Xiu-Xing Wang, Pu Ying, Fan Diao, Qiang Wang, Dan Ye, Chen Jiang, Ning Shen, Na Xu, Wei-Bo Chen, Shan-Shan Lai, Shan Jiang, Xiao-Li Miao, Jin Feng, Wei-Wei Tao, Ning-Wei Zhao, Bing Yao, Zhi-Peng Xu, Hai-Xiang Sun, Jian-Min Li, Jia-Hao Sha, Xing-Xu Huang, Qing-Hua Shi, Hong Tang, Xiang Gao, Chao-Jun Li. Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection. Journal of Experimental Medicine07/2013; 210 (8). IF: 17.579. 中科院一区.
共同作者41篇：
1. Deguan Lv, Deobrat Dixit, Andrea F Cruz, Leo J Y Kim, Likun Duan, Xin Xu, Qiulian Wu, Cuiqing Zhong, Chenfei Lu, Zachary C Gersey, Ryan C Gimple, Qi Xie, Kailin Yang, Xiaojing Liu, Xiaoguang Fang, Xujia Wu, Reilly L Kidwell, Xiuxing Wang, Shideng Bao, Housheng H He, Jason W Locasale, Sameer Agnihotri, Jeremy N Rich. Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2. Cell Metabolism, 2024 Oct 19:S1550-4131(24)00396-6. 中科院一区.
2. Jian Zhong, Xudong Xing, Yixin Gao, Lei Pei, Chenfei Lu, Huixin Sun, Yanxing Lai, Kang Du, Feizhe Xiao, Ying Yang, Xiuxing Wang, Yu Shi, Fan Bai, Nu Zhang. Distinct roles of TREM2 in central nervous system cancers and peripheral cancers. Cancer Cell, 2024 Jun 10;42(6):968-984.e9. 中科院一区.
3. Mengdie Li, Zhixiang Zhang, Liuguijie He, Xiefeng Wang, Jianxing Yin, Xiuxing Wang, Yongping You, Xu Qian, Xin Ge, Zhumei Shi. SMYD2 induced PGC1alpha methylation promotes stemness maintenance of glioblastoma stem cells. Neuro-Oncology, 2024 Sep 5;26(9):1587-1601. 中科院一区.
4. Min Wu, Tingting Wang, Nan Ji, Ting Lu, Ran Yuan, Lingxiang Wu, Junxia Zhang, Mengyuan Li, Penghui Cao, Jiarui Zhao, Guanzhang Li, Jianyu Li, Yu Li, Yujie Tang, Zhengliang Gao, Xiuxing Wang, Wen Cheng, Ming Ge, Gang Cui, Rui Li, Anhua Wu, Yongping You, Wei Zhang, Qianghu Wang, Jian Chen. Multi-omics and pharmacological characterization of patient-derived glioma cell lines. Nature Communications, 2024 Aug 8;15(1):6740. 中科院一区.
5. Zehe Ge, Miao Xu, Yuqian Ge, Guang Huang, Dongyin Chen, Xiuquan Ye, Yibei Xiao, Hongyu Zhu, Rong Yin, Hua Shen, Gaoxiang Ma, Lianwen Qi, Guining Wei, Dongmei Li, Shaofeng Wei, Meng Zhu, Hongxia Ma, Zhumei Shi, Xiuxing Wang, Xin Ge, Xu Qian. Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation. Cell Reports, 2023 Nov 10;42(11):113417. IF: 9.995. 中科院一区.
6. Deguan Lv, Cuiqing Zhong, Deobrat Dixit, Kailin Yang, Qiulian Wu, Bhaskar Godugu, Briana C Prager, Guofeng Zhao, Xiuxing Wang, Qi Xie, Shideng Bao, Chuan He, Dieter Henrik Heiland, Michael G Rosenfeld, Jeremy N Rich. EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma. Molecular Cell, 2023 Nov 8:S1097-2765(23)00862-6. IF: 19.328. 中科院一区.
7. Jianxing Yin, Xiefeng Wang, Xin Ge, Fangshu Ding, Zhumei Shi, Zehe Ge, Guang Huang, Ningwei Zhao, Dongyin Chen, Junxia Zhang, Sameer Agnihotri, Yuandong Cao, Jing Ji, Fan Lin, Qianghu Wang, Qigang Zhou, Xiuxing Wang, Yongping You, Zhimin Lu, Xu Qian. Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas. Nature Communications, 2023 Sep 22;14(1):5913. IF: 17.694. 中科院一区.
8. Handong Sun, Lishen Zhang, Zhonglin Wang, Danling Gu, Mengyan Zhu, Yun Cai, Lu Li, Jiaqi Tang, Bin Huang, Bakwatanisa Bosco, Ning Li, Lingxiang Wu, Wei Wu, Liangyu Li, Yuan Liang, Lin Luo, Quanzhong Liu, Yanhui Zhu, Jie Sun, Liang Shi, Tiansong Xia, Chuang Yang, Qitong Xu, Xue Han, Weiming Zhang, Jianxia Liu, Dong Meng, Hua Shao, Xiangxin Zheng, Shuqin Li, Hua Pan, Jing Ke, Wenying Jiang, Xiaolan Zhang, Xuedong Han, Jian Chu, Hongyin An, Juyan Ge, Chi Pan, Xiuxing Wang, Kening Li, Qianghu Wang, Qiang Ding. Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer. Nature Communications, 2023 Sep 11;14(1):5590. IF: 17.694. 中科院一区.
9. Weiwei Tao, Hong Lei, Wenlong Luo, Zhi Huang, Peng Ling, Mengyue Guo, Lihao Wan, Kui Zhai, Qian Huang, Qiulian Wu, Shutong Xu, Liang Zeng, Xiuxing Wang, Zhiqiang Dong, Jeremy N Rich, Shideng Bao. Novel INHAT repressor drives glioblastoma growth by promoting ribosomal DNA transcription in glioma stem cells. Neuro-Oncology, 08/2023; 25(8):1428-1440. IF: 13.029. 中科院一区.
10. Nunu Huang, Zhipeng Chen, Xuesong Yang, Yixin Gao, Jian Zhong, Yan Li, Feizhe Xiao, Xiuxing Wang, Yu Shi, Nu Zhang. Upstream Open Reading Frame-encoded MP31 Disrupts the Mitochondrial Quality Control Process and Inhibits Tumorigenesis in Glioblastoma. Neuro-Oncology, 06/2023; noad099. IF: 13.029. 中科院一区.
11. Zengpanpan Ye, Xiaolin Ai, Kailin Yang, Zhengnan Yang, Fan Fei, Xiaoling Liao, Zhixin Qiu, Ryan C Gimple, Huairui Yuan, Hao Huang, Yanqiu Gong, Chaoxin Xiao, Jing Yue, Liang Huang, Olivier Saulnier, Wei Wang, Peidong Zhang, Lunzhi Dai, Xin Wang, Xiuxing Wang, Young Ha Ahn, Chao You, Jianguo Xu, Xiaoxiao Wan, Michael D Taylor, Linjie Zhao, Jeremy N Rich, Shengtao Zhou. Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma. Cancer Discovery, 04/2023; 13(4). IF: 38.272. 中科院一区.
12. Mengjie Zhao, Yanhui Li, Chenfei Lu, Fangshu Ding, Miao Xu, Xin Ge, Mengdie Li, Zhen Wang, Jianxing Yin, Junxia Zhang, Xiefeng Wang, Zehe Ge, Hong Xiao, Yong Xiao, Hongyi Liu, Wentao Liu, Yuandong Cao, Qianghu Wang, Yongping You, Xiuxing Wang, Kun Yang, Zhumei Shi, Xu Qian. PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma. Cancer Research 04/2023; 83(7). IF: 13.312. 中科院一区.
13. Min Wu, Lingxiang Wu, Wei Wu, Mengyan Zhu, Jianyu Li, Ziyu Wang, Jie Li, Rong Ding, Yuan Liang, Liangyu Li, Tingting Zhang, Bin Huang, Yun Cai, Kening Li, Lu Li, Rui Zhang, Baoli Hu, Fan Lin, Xiuxing Wang, Siyuan Zheng, Jian Chen, Yongping You, Tao Jiang, Junxia Zhang, Hongshan Chen, Qianghu Wang. Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow-Derived Macrophages. Cancer Research03/2023; 83(5). IF: 13.312. 中科院一区.
14. Lingxiang Wu, Wei Wu, Junxia Zhang #, Zheng Zhao #, Liangyu Li, Mengyan Zhu, Min Wu, Fan Wu, Fengqi Zhou, Yuxin Du, Rui-Chao Chai, Wei Zhang, Xiaoguang Qiu, Quanzhong Liu, Ziyu Wang, Jie Li, Kening Li, Apeng Chen, Yinan Jiang, Xiangwei Xiao, Han Zou, Rashmi Srivastava, Tingting Zhang, Yun Cai, Yuan Liang, Bin Huang, Ruohan Zhang, Fan Lin, Lang Hu, Xiuxing Wang, Xu Qian, Sali Lv, Baoli Hu, Siyuan Zheng, Zhibin Hu, Hongbing Shen, Yongping You, Roel G W Verhaak, Tao Jiang, Qianghu Wang. Natural Coevolution of Tumor and Immunoenvironment in Glioblastoma. Cancer Discovery, 12/2022, 12(12).IF: 38.272. 中科院一区.
15. Deguan Lv, Ryan C Gimple, Cuiqing Zhong, Qiulian Wu, Kailin Yang, Briana C Prager, Bhaskar Godugu, Zhixin Qiu, Linjie Zhao, Guoxin Zhang, Deobrat Dixit, Derrick Lee, Jia Z Shen, Xiqing Li, Qi Xie, Xiuxing Wang, Sameer Agnihotri, Jeremy N Rich. PDGF signaling inhibits mitophagy in glioblastoma stem cells through N6-methyladenosine. Developmental Cell 06/2022; 57(12). IF: 13.417. 中科院一区.
16. Jin-Zhu Wang, Hong Zhu, Pu You, Hui Liu, Wei-Kang Wang, Xiaojuan Fan, Yun Yang, Keren Xu, Yingfeng Zhu, Qunyi Li, Ping Wu, Chao Peng, Catherine Cl Wong, Kaicheng Li, Yufeng Shi, Nu Zhang, Xiuxing Wang, Rong Zeng, Ying Huang, Liusong Yang, Zefeng Wang, Jingyi Hui. Upregulated YB-1 protein promotes glioblastoma growth through a YB-1/CCT4/mLST8/mTOR pathway. Journal of Clinical Investigation04/2022; 132 (8). IF: 19.477. 中科院一区.
17. Brian J Golbourn, Matthew E Halbert, Katharine Halligan, Srinidhi Varadharajan, Brian Krug, Nneka E Mbah, Nisha Kabir, Ann-Catherine J Stanton, Abigail L Locke, Stephanie M Casillo, Yanhua Zhao, Lauren M Sanders, Allison Cheney, Steven J Mullett, Apeng Chen, Michelle Wassell, Anthony Andren, Jennifer Perez, Esther P Jane, Daniel R David Premkumar, Robert F Koncar, Shideh Mirhadi, Lauren H McCarl, Yue-Fang Chang, Yijen L Wu, Taylor A Gatesman, Andrea F Cruz, Michal Zapotocky, Baoli Hu, Gary Kohanbash, Xiuxing Wang, Alenoush Vartanian, Michael F Moran, Frank Lieberman, Nduka M Amankulor, Stacy G Wendell, Olena M Vaske, Ashok Panigrahy James Felker, Kelsey C Bertrand, Claudia L Kleinman, Jeremy N Rich, Robert M Friedlander, Alberto Broniscer, Costas Lyssiotis, Nada Jabado, Ian F Pollack, Stephen C Mack, Sameer Agnihotri. Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome. Nature Cancer05/2022; 3(5). IF: 23.177. 中科院一区.
18. Zhumei Shi, Xin Ge, Mengdie Li, Jianxing Yin, Xiefeng Wang, Junxia Zhang, Dongyin Chen, Xinjian Li, Xiuxing Wang, Jing Ji, Yongping You, Xu Qian. Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas. Molecular Cell 10/2022; 82(20). IF: 19.328. 中科院一区.
19. Yangyang Tian, Zehe Ge, Miao Xu, Xin Ge, Mengjie Zhao, Fangshu Ding, Jianxing Yin, Xiuxing Wang, Yongping You, Zhumei Shi, Xu Qian. Diallyl trisulfide sensitizes radiation therapy on glioblastoma through directly targeting thioredoxin 1. Free Radical Biology and Medicine 08/2022;189. IF: 8.101. 中科院一区.
20. Weiwei Tao, Hong Lei, Wenlong Luo, Zhi Huang, Peng Ling, Mengyue Guo, Lihao Wan, Kui Zhai, Qian Huang, Qiulian Wu, Shutong Xu, Liang Zeng, Xiuxing Wang, Zhiqiang Dong, Jeremy N Rich, Shideng Bao. NIR Drives Glioblastoma Growth by Promoting Ribosomal DNA Transcription in Glioma Stem Cells. Neuro-Oncology 12/2022. IF: 13.029. 中科院一区.
21. Zhixin Qiu, Linjie Zhao, Jia Z Shen, Zhengyu Liang, Qiulian Wu, Kailin Yang, Lihua Min, Ryan C Gimple, Qiyuan Yang, Shruti Bhargava, Chunyu Jin, Cheryl Kim, Denise Hinz, Deobrat Dixit, Jean A Bernatchez, Briana C Prager, Guoxin Zhang, Zhen Dong, Deguan Lv, Xujun Wang, Leo JY Kim, Zhe Zhu, Katherine A Jones, Ye Zheng, Xiuxing Wang, Jair L Siqueira-Neto, Lukas Chavez, Xiang-Dong Fu, Charles Spruck, Jeremy N Rich. Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells. Cancer Discovery 1/2021. IF: 38.272. 中科院一区.
22. Deobrat Dixit, Briana C Prager, Ryan C Gimple, Tyler E Miller, Qiulian Wu, Shira Yomtoubian, Reilly L Kidwell, Deguan Lv, Linjie Zhao, Zhixin Qiu, Guoxin Zhang, Derrick Lee, Donglim Esther Park, Robert J Wechsler-Reya, Xiuxing Wang, Shideng Bao, Jeremy N Rich. Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases. Science Translational Medicine 1/2022;14(626).
23. Guoxin Zhang, Zhen Dong, Ryan C Gimple, Arthur Wolin, Qiulian Wu, Zhixin Qiu, Lisa M Wood, Jia Z Shen, Li Jiang, Linjie Zhao, Deguan Lv, Briana C Prager, Leo JY Kim, Xiuxing Wang, Lingdi Zhang, Ryan L Anderson, Jeffrey K Moore, Shideng Bao, Thomas H Keller, Grace Lin, Congbao Kang, Petra Hamerlik, Rui Zhao, Heide L Ford, Jeremy N Rich. Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe. Journal of Experimental Medicine. 10/2021. 218(11).
24. Weiwei Tao, Aili Zhang, Kui Zhai, Zhi Huang, Haidong Huang, Wenchao Zhou, Qian Huang, Xiaoguang Fang, Briana C Prager, Xiuxing Wang, Qiulian Wu, Andrew E Sloan, Manmeet S Ahluwalia, Justin D Lathia, Jennifer S Yu, Jeremy N Rich, Shideng Bao. SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells. EMBO molecular medicine. 12/2020. 12(12).
25. Briana C Prager, Harish N Vasudevan, Deobrat Dixit, Jean A Bernatchez, Qiulian Wu, Lisa C Wallace, Shruti Bhargava, Derrick Lee, Bradley H King, Andrew R Morton, Ryan C Gimple, Melike Pekmezci, Zhe Zhu, Jair L Siqueira-Neto, Xiuxing Wang, Qi Xie, Clark Chen, Gene H Barnett, Michael A Vogelbaum, Stephen C Mack, Lukas Chavez, Arie Perry, David R Raleigh, Jeremy N Rich. The meningioma enhancer landscape delineates novel subgroups and drives druggable dependencies. Cancer discovery, 11/2020, 10(11). IF: 38.272. 中科院一区.
26. Ryan Gimple, Xiuxing Wang* RAS: Striking at the Core of the Oncogenic Circuitry. Frontiers in Oncology, 08/2019.
27. Andrew R. Morton, Nergiz Dogan-Artun, Zachary J. Faber, Graham MacLeod, Cynthia F. Bartels, Megan S. Piazza, Kevin C. Allan, Stephen C. Mack, Xiuxing Wang, Ryan C. Gimple, Qiulian Wu, Brian P. Rubin, Shashirekha Shetty, Stephane Angers, Peter B. Dirks, Richard C. Sallari, Mathieu Lupien, Jeremy N. Rich,* and Peter C. Scacheri* Functional Enhancers Shape Extrachromosomal Oncogene Amplifications. Cell, 11/2019.
28. Stephen C. Mack, Kristian W. Pajtler, Lukas Chavez, Konstantin Okonechnikov, Kelsey C. Bertrand, Xiuxing Wang, Serap Erkek, Alexander Federation, Anne Song, Christine Lee, Xin Wang, Laura McDonald, James J. Morrow, Alina Saiakhova, Patrick Sin-Chan, Qiulian Wu, Kulandaimanuvel Antony Michaelraj, Tyler E. Miller, Christopher G. Hubert, Marina Ryzhova, Livia Garzia, Laura Donovan, Stephen Dombrowski, Daniel C. Factor, Betty Luu, Claudia L. L. Valentim, Ryan C. Gimple, Andrew Morton, Leo Kim, Briana C. Prager, John J. Y. Lee, Xiaochong Wu, Jennifer Zuccaro, Yuan Thompson, Borja L. Holgado, Jüri Reimand, Susan Q. Ke, Adam Tropper, Sisi Lai, Senthuran Vijayarajah, Sylvia Doan, Vaidehi Mahadev, Ana Fernandez Miñan, Susanne N. Gröbner, Matthias Lienhard, Marc Zapatka, Zhiqin Huang, Kenneth D. Aldape, Angel M. Carcaboso, Peter J. Houghton, Stephen T. Keir, Till Milde, Hendrik Witt, Yan Li, Chao-Jun Li, Xiu-Wu Bian, David T. W. Jones, Ian Scott, Sheila K. Singh, Annie Huang, Peter B. Dirks, Eric Bouffet, James E. Bradner, Vijay Ramaswamy, Nada Jabado, James T. Rutka, Paul A. Northcott, Mathieu Lupien, Peter Lichter, Andrey Korshunov, Peter C. Scacheri, Stefan M. Pfister, Marcel Kool*, Michael D. Taylor*, Jeremy N. Rich* Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling. Nature 12/2017; 553(7686).
29. Xun Jin, Leo J Y Kim, Qiulian Wu, Lisa C Wallace, Briana C Prager, Tanwarat Sanvoranart, Ryan C Gimple, Xiuxing Wang, Stephen C Mack, Tyler E Miller, Ping Huang, Claudia L Valentim, Qi-gang Zhou, Jill S Barnholtz-Sloan, Shideng Bao, Andrew E Sloan, Jeremy N Rich*. Targeting glioma stem cells through combined BMI1 and EZH2 inhibition. Nature Medicine 10/2017; 23(11).
30. Zhe Zhu, Pinar Mesci, Jean A.Bernatchez, Ryan C.Gimple, Xiuxing Wang, Simon T.Schafer, Hiromi I.Wettersten, Sungjun Beck, Alex E.Clark, Qiulian Wu, Briana C. Prager, Leo J.Y. Kim, Rekha Dhanwani, Sonia Sharma, Alexandra Garancher, Sara M.Weis, Stephen C.Mack, Priscilla D.Negraes,Cleber A.Trujillo, Luiz O.Penalva, Jing Feng, Zhou Lan, Rong Zhang, Alex W.Wessel, Sanjay Dhawan, Michael S.Diamond, Clark C.Chen, Robert J.Wechsler-Reya, Fred H.Gage, Hongzhen Hu, Jair L.Siqueira-Neto, Alysson R.Muotri, David A.Cheresh, Jeremy N.Rich. Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis. Cell Stem Cell 02/2020; 26(2), 187-204.
31. Yu Shi, Olga A Guryanova, Wenchao Zhou, Chong Liu, Zhi Huang, Xiaoguang Fang, Xiuxing Wang, Cong Chen, Qiulian Wu, Zhicheng He, Wei Wang, Wei Zhang, Tao Jiang, Qing Liu, Yaping Chen, Wenying Wang, Jingjing Wu, Leo Kim, Ryan C Gimple, Hua Feng, Hsiang-Fu Kung, S Yu Jennifer, Jeremy N Rich, Yi-Fang Ping*, Xiu-Wu Bian*, Shideng Bao*. Ibrutinib Targets Glioblastoma Stem Cells by Disrupting BMX-mediated STAT3 Activation to Suppress Malignant Growth and Radioresistance. Science Translational Medicine. 2018. IF: 19.343. 中科院一区.
32. Zhe Zhu, Matthew J. Gorman, Lisa D. McKenzie, Jiani N. Chai, Christopher G. Hubert, Briana C. Prager, Estefania Fernandez, Justin M. Richner, Rong Zhang, Chao Shan, Xiuxing Wang, Pei-Yong Shi, Michael S. Diamond*, Jeremy N. Rich*, Milan G. Chheda*. Zika virus has oncolytic activity against glioblastoma stem cells. Journal of Experimental Medicine 09/2017; 214(9). IF: 17.579. 中科院一区.
33. Ryan C Gimple, Reilly L. Kidwell, Leo Kim, Tengqian Sun, AnthonyD. Gromovsky, Qiulian Wu, Megan Wolf, Deguan Lv, Shruti Bhargava, Li Jiang, Briana C Prager, Xiuxing Wang, Qing Ye, Zhe Zhu, Guoxin Zhang, Zhen Dong, Linjie Zhao, Derrick Lee, Junfeng Bi, Andrew E. Sloan.Paul S. Mischel, Mark Brown, Hu Cang, Tao Huan, Stephen C. Mack, Qi Xie, Jeremy Rich*. Glioma Stem Cell Specific Super Enhancer Promotes Polyunsaturated Fatty Acid Synthesis to Support EGFR Signaling. Cancer Discovery, 06/2019, 0.1158/2159-8290. IF: 38.272. 中科院一区.
34. Zhen Dong, Guoxin Zhang, Meng Qu, Ryan C. Gimple, Qiulian Wu, Zhixin Qiu, Briana C. Prager, Xiuxing Wang, Leo J.Y. Kim, Andrew R. Morton, Deobrat Dixit, Wenchao Zhou, Haidong Huang, Bin Li, Zhe Zhu, Shideng Bao, Stephen C. Mack, Lukas Chavez, Steve A. Kay, Jeremy N. Rich. Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock. Cancer Discovery, 08/2019. IF: 38.272. 中科院一区.
35. Yu Shi, Yi-Fang Ping, Wenchao Zhou, Zhi-Cheng He, Cong Chen, Bai-Shi-Jiao Bian, Lin Zhang, Lu Chen, Xun Lan, Xian-Chao Zhang, Kai Zhou, Qing Liu, Hua Long, Ti-Wei Fu, Xiao-Ning Zhang, Mian-Fu Cao, Zhi Huang, Xiaoguang Fang, Xiuxing Wang, Hua Feng, Xiao-Hong Yao, Shi-Cang Yu, You-Hong Cui, Xia Zhang, Jeremy N. Rich, Shideng Bao*, Xiu-Wu Bian*.Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth. Nature Communications 06/2017; 8. IF: 17.690. 中科院一区.
36. Weiwei Tao, Chengwei Chu, Wenchao Zhou, Zhi Huang, Kui Zhai, Xiaoguang Fang, Qian Huang, Aili Zhang, Xiuxing Wang, Xingjiang Yu, Haidong Huang, Qiulian Wu, Andrew E. Sloan, Jennifer S. Yu, Xiaoxia Li, George R. Stark, Jeremy N. Rich, Shideng Bao. Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma. Nature Communications, 06/2020, 11. IF: 17.690. 中科院一区.
37. Jinkyu Jung, Leo J.Y. Kim, Xiuxing Wang, Qiulian Wu, Tanwarat Sanvoranart, Christopher G. Hubert, Briana C. Prager, Lisa C. Wallace, Xun Jin, Stephen C. Mack, Jeremy N. Rich*. Nicotinamide metabolism regulates glioblastoma stem cell maintenance. JCI Insight 05/2017; 2(10). IF: 9.484. 中科院一区.
38. Xiaoguang Fang, Wenchao Zhou, Qiulian Wu, Zhi Huang, Yu Shi, Kailin Yang, Cong Chen, Qi Xie, Stephen C. Mack, Xiuxing Wang, Angel M. Carcaboso, Andrew E. Sloan, Gaoliang Ouyang, Roger E. McLendon, Xiu-wu Bian, Jeremy N. Rich, Shideng Bao*. Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination. Journal of Experimental Medicine 12/2016; 214(1). IF: 17.579. 中科院一区.
39. Qi Xie, Qiulian Wu, Leo Kim, Tyler E. Miller, Brian B. Liau, Stephen C. Mack, Kailin Yang, Daniel C. Factor, Xiaoguang Fang, Zhi Huang, Wenchao Zhou, Kareem Alazem, Xiuxing Wang, Bradley E. Bernstein, Shideng Bao, Jeremy N. Rich*. RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation. Journal of Clinical Investigation 06/2016; 126(7). IF: 19.477. 中科院一区.
40. Chen Jiang, Fan Diao, Yong-Juan Sang, Na Xu, Rui-Lou Zhu, Xiu-Xing Wang, Zhong Chen, Wei-Wei Tao, Bing Yao, Hai-Xiang Sun, Xing-Xu Huang, Bin Xue, Chao-Jun Li: GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. PLoS Genetics 01/2017; 13(1). IF: 6.02. 中科院二区.
41. Fan Diao, Chen Jiang, Xiu-Xing Wang, Rui-Lou Zhu, Qiang Wang, Bing Yao, Chao-Jun Li: Alteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice. Scientific Reports 07/2016; 6:28917. IF: 4.997. 中科院三区.
