李建平，教授，博士，博士生导师
科研方向：病原微生物耐药性机制与干预
联系方式
通讯：江苏省南京市江宁区龙眠大道101号基础医学院病原生物学系，邮编211166
电邮：JianpingLi@njmu.edu.cn
简介
李建平，国家级高层次青年人才，教授、博士生导师。2016年博士毕业于中国科学院精密测量科学与技术创新研究院（原中科院武汉物理与数学研究所）。2018年2月-2025年5月，在美国纽约大学做博士后和研究助理教授。主要从事病原菌多重耐药性的分子机制与干预研究，相关成果分别发表于PNAS、Nature Communications（两篇）及JACS等权威期刊。
承担科研课题
国家自然科学基金青年项目，发展用于解析膜蛋白三维结构的固体NMR PRE-Rosetta方法，项目号：21605156，资助金额：20万，起止：2017.1–2019.12，结题，主持
代表性论文
1. Jianping Li, Yan Li, Akiko Koide, Huihui Kuang, Victor J. Torres, Shohei Koide, Da-Neng Wang & Nathaniel J. Traaseth. Proton-coupled transport mechanism of the efflux pump NorA. Nat. Commun.. 2024, 15: 4494.
2. Jianping Li#, Ampon Sae Her#, Alida Besch#, Belen Ramirez-Cordero, Maureen Crames, James R. Banigan, Casey Mueller, William M. Marsiglia, Yingkai Zhang & Nathaniel J. Traaseth. Dynamics underlie the drug recognition mechanism by the efflux transporter EmrE. Nat. Commun., 2024, 15: 4537.
3. Jianping Li#, Ampon Sae Her#, and Nathaniel J. Traaseth. Asymmetric protonation of glutamate residues drives a preferred transport pathway in EmrE. Proc. Natl. Acad. Sci. U.S.A., 2021, 118: e2110790118.
4. Jianping Li,Kala Bharath Pilla, Qingfeng Li, Zhengfeng Zhang, Xuncheng Su, Thomas Huber and Jun Yang. Magic angle spinning NMR structure determination of proteins from pseudocontact shifts, J. Am. Chem. Soc.. 2013, 135: 8294−8303.
5. Jianping Li, Yang Shen, Yanke Chen, Zhengfeng Zhang, Shaojie Ma, Qianfen Wan, Qiong Tong, Clemens Glaubitz, Maili Liu & Jun Yang. Structure of membrane diacylglycerol kinase in lipid bilayers. Commun. Biol., 2021, 4:282.
6. Jianping Li#, Ampon Sae Her#, and Nathaniel J. Traaseth. Site-specific resolution of anionic residues in proteins using solid-state NMR spectroscopy. J. Biomol. NMR., 2020, 74: 355-363.
7. Douglas N. Brawley, David B. Sauer&, Jianping Li&, Xuhui Zheng&, Akiko Koide&, Ganesh S. Jedhe, Tiffany Suwatthee, Jinmei Song, Zheng Liu, Paramjit S. Arora, Shohei Koide, Victor J. Torres, Da-Neng Wang and Nathaniel J. Traaseth. Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus. Nat. Chem. Biol., 2022, 18: 706-712.
8. Lauren Wallon , Imran Khan, Kai Wen Teng, Akiko Koide, Mariyam Zuberi, Jianping Li , Gayatri Ketavarapu , Nathaniel J. Traaseth , John P. O’Bryan, and Shohei Koide. Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket. Proc. Natl. Acad. Sci. U.S.A.,2022,119: e2204481119.
9. Linhai Jiang, Xiaobing Zuo, Jianping Li, Nathaniel J. Traaseth, and Kent Kirshenbaum. Programmed supramolecular assemblies using orthogonal pairs of heterodimeric coiled coil peptides. Angew. Chemie. Int. Ed., 2022, 61: e202201895.
10.Yanke Chen, Zhengfeng Zhang, Xinqi Tang, Jianping Li, Clemens Glaubitz, and Jun Yang. Conformation and topology of diacylglycerol kinase in E.coli membranes revealed by solid-state NMR spectroscopy, Angew. Chem. Int. Ed., 2014, 53: 5624 –5628.
长期招聘
本课题组将聚焦我国临床上高度关注的“多重耐药病原体”（特别是肺炎克雷伯菌），研究内容涵盖耐药分子机制解析以及新型抗菌策略（如抑制剂筛选等），旨在解决我国临床上严重的多重耐药问题。课题组将长期招聘博士后、讲师及副教授，也欢迎感兴趣的学生报考硕士和博士。
