王钰，副教授，博士，硕士生导师
科学研究方向
通过药物筛选和CRISPR筛选，鉴定治疗遗传性贫血、肿瘤相关性贫血和衰老相关性贫血的新靶点，淋巴瘤和白血病的治疗新靶点鉴定与靶向干预
联系方式
通讯：江苏省南京市江宁区龙眠大道101号细胞生物学系，邮编211166
电邮：yu_wang@njmu.edu.cn
简介
本科毕业于南京农业大学；博士毕业于北京协和医学院（中国医学科学院）血液学研究所（血液病医院），主要研究方向是人多能干细胞早期造血分化的调控，在Cell Reports等期刊以独立一作或共同一作发表文章；2019-2024年于美国密歇根大学医学院细胞与发育生物学系进行博士后工作，主要研究方向是红细胞生成、血红蛋白转换的调控与遗传性贫血的治疗，致力于靶向表观遗传调控因子LSD1治疗镰刀型贫血，在Blood以独立一作发表文章2篇，在Blood, Nature Communications, Blood Advance等期刊参与发表文章多篇，申请国际专利一项。
代表性论文
(1) Yu Wang, Greggory Myers, Lei Yu, Kaiwen Deng, Ginette Balbin-Cuesta, Sharon A. Singh, Yuanfang Guan, Rami Khoriaty, James Douglas Engel. TR4 and BCL11A Repress γ-globin Transcription via Independent Mechanisms. Blood, 2024, 144(26): 2762-2772
(2) Yu Wang, Lei Yu, Kaiwen Deng, Mathivanan Packiarajan, Angelo Aguilar, Sojin An, Xiaofang Liu, Greggory Myers, Hoon Oh, Sharon A. Singh, Uhn-soo Cho, Shaomeng Wang, Yuanfang Guan, Andy White, Rami Khoriaty, James Douglas Engel*. Novel, potent, and orally bioavailable LSD1 inhibitors induce fetal hemoglobin synthesis in a sickle cell disease mouse model. Blood, 2025(已接收, online)
(3) Yu Wang, Hongtao Wang, Jiaojiao Guo, Jie Gao, Mengge Wang, Meijuan Xia, Yuqi Wen, Pei Su, Ming Yang, Mingyao Liu, Lihong Shi, Tao Cheng, Wen Zhou, Jiaxi Zhou*. LGR4, Not LGR5, Enhances hPSC Hematopoiesis by Facilitating Mesoderm Induction via TGF-Beta Signaling Activation.Cell Reports, 2020, 31(5)
(4) Yu Wang, Jie Gao, Hongtao Wang, Mengge Wang, Yuqi Wen, Jiaojiao Guo, Pei Su, Lihong Shi, Wen Zhou, Jiaxi Zhou*. R-spondin2 promotes hematopoietic differentiation of human pluripotent stem cells by activating TGF beta signaling. Stem Cell Research & Therapy, 2019, 10
(5) Hongtao Wang#, Mengge Wang#, Yu Wang#, Yuqi Wen, Xiaoyuan Chen, Dan Wu, Pei Su, Wen Zhou, Lihong Shi, Jiaxi Zhou*. MSX2 suppression through inhibition of TGFβsignaling enhances hematopoietic differentiation of human embryonic stem cells. Stem Cell Research & Therapy, 2020, 11(1) (#共同作者)
(6) Yu Wang, Lei Yu, James Douglas Engel, Sharon A. Singh, Epigenetic activities in erythroid cell gene regulation. Seminars in Hematology, 2021, 58(1): 4-9
(7) Lei Yu, Greggory Myers, Chia-Jui Ku, Emily Schneider, Yu Wang, Sharon A. Singh, NateeJearawiriyapaisarn, Andrew White, Takashi Moriguchi, Rami Khoriaty, Masayuki Yamamoto, Michael G. Rosenfeld, Julien Pedron, John H. Bushweller, Kim-Chew Lim, James Douglas Engel. An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation.Blood, 2021, 138(18): 1691- 1704
(8) Greggory Myers, Yu Wang, Qing Wang, Ann Friedman, Alejandra Sarai Sanchez Martinez, Xiaofang Liu, Singh A Sharon, Kim Chew Lim, Rami Khoriaty, James Douglas Engel, Lei Yu. Murine erythroid differentiation kinetics in vivo under normal and anemic stress conditions. Blood Advances, 2023, 7(19): 5727-5732
(9) Lei Yu, Philippe Lemay, Alexander V Ludlow, Marie-Claude Guyot, Morgan Alexander Jones, Fatma F Mohamed, Ghazi-Abullah Saroya, Christopher Panaretos, Emily Schneider, Yu Wang, Greggory Myers, Rami Khoriaty, Qing Li, Renny Franceschi, James Douglas Engel, Vesa Kaartinen, Thomas L Rothstein, Monica J Justice, Zoha Kibar, Sharon A Singh. A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia. Blood Advances, 2021, 5(20): 4167-4178
(10) Lei Yu, Greggory Myers, Emily Schneider, Yu Wang, Raven Mathews, Kim Chew Lim, David Siemieniak, Vi T Tang, David Ginsburg, Ginette Balbin-Cuesta, Sharon A Singh, Pongpon Phuwakanjana, Natee Jearawiriyapaisarn, Rami Khoriaty, James Douglas Engel. Identification of Novel γ-globin Inducers Among All Current Potential Erythroid Druggable Targets. Blood Advances, 2022, 6(11): 3280-3285
(11) Greggory Myers, Ann Friedman, Lei Yu, Narges Pourmandi, Claire Kerpet, Masaki A. Ito, Rilie Saba, Vi Tang, Ayse Bilge Ozel, Ingrid L. Bergin, Craig N. Johnson, Chia-Jui Ku, Yu Wang, Ginette Balbin-Cuesta, Kim-Chew Lim, Zesen Lin, Claire Drysdale, Beth McGee , Ryo Kurita, Yukio Nakamura, Xiaofang Liu, David Siemieniak, Sharon A. Singh, Costas A. Lyssiotis, Ivan Maillard, Lois S. Weisman, James Douglas Engel& Rami Khoriaty. A genome-wide screen identifies genes required for erythroid differentiation. Nat Commun. 2025 Apr 12;16(1):3488.
(12) Yu Wang, Lei Yu, Greggory Myers, Sharon A Singh, James Engel ; Direct and Indirect Functions of TR4 in the Control of Fetal Hemoglobin Silencing, the 65th ASH Annual Meeting, San Diego, CA, 2023-12-9至2023-12-12 (会议报告)
(13) Lei Yu, Yu Wang, Richard King, Greggory Myers, Beth McGee, Ann Friedman, Ginette Balbin-Cuesta, Zesen Lin, Claire Drysdale, Xiaofang Liu, Claire Kerpet, Kaiwen Deng, Aaron Robida, James Engel, Rami Khoriaty ; The LSD1 Inhibitor RN1 Rescues Congenital Dyserythropoietic Anemia Type II, the 66th ASH Annual Meeting, San Diego, CA, US, 2024-12-7至2024-12-10 (会议论文)
授权专利
Mathivanan Packiarajan, Yu Wang, Andrew D. White, James Douglas Engel, Lei Yu ; OXYGENATED HETEROCYCLIC LSD-1 INHIBITORS AND RELATED METHODS OF USE, 2024-9-27, WIPO, PCT/US2024/048808 (专利申请)
