冯高谦，教授，博士，博士生导师，行政职务
科学研究方向
反向疫苗学
蚊媒病感染与免疫
基因工程单克隆抗体技术
联系方式
通讯：江苏省南京市江宁区龙眠大道101号基础医学病原生物学系，邮编211166
电邮：fenggaoqian@njmu.edu.cn
简介
冯高谦，博士，南京医科大学教授，江苏省特聘教授，博士生导师。主要从事包括疟原虫在内的寄生虫感染与宿主保护性免疫机制方面的研究，以及通过反向疫苗学开发新型疫苗等工作。曾主持国家自然科学基金项目，澳大利亚NHMRC Ideas Grant，CASS基金会Science and Medicine Grant，作为主要参与人参与多项PATH-MVI研究项目。近年来以第一作者在Nature Communications，BMC Medicine，Journal of Infectious Diseases等高水平期刊发表多篇论文。据Web of Science检索，H指数为24。
教育背景及工作经历
2007年-2011年澳大利亚墨尔本大学医学院博士
2011年-2018年澳大利亚Burnet医学研究所 Research Officer
2018年-2023年澳大利亚Burnet医学研究所 Senior Research Officer
2023年-现在 南京医科大学病原生物系教授
学术兼职
世界卫生组织快速诊断试剂资格预评估专家
Frontiers in Cellular and Infection Microbiology 编委
Decoding Transmission and Infection 编委
中国寄生虫学与寄生虫病杂志青年编委
承担科研课题
1主持人
2025-2028 | 疟原虫环子孢子蛋白特异性抗体高效激活Fcγ受体的分子机制研究 | 国家自然科学基金面上项目 | 主持人 |
2020-2022 | Harnessing host immunity against disease vectors | CASS Foundation | 主持人 |
2018-2019 | Understanding RTS,S immunity to inform vaccine implementation and design an improved pre-erythrocyte stage vaccine to facilitate malaria elimination | Australia Center for Research Excellence in Malaria Elimination | 主持人 |
2016-2017 | Developing an effective vaccine against malaria that overcomes immune evasion | CASS Foundation | 主持人 |
2019-2022 | Enhanced identification of targets of immunity to advance P. vivax vaccine development | Australian NHMRC Ideas Grant | 共同主持人 |
代表性论文
1. Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children Feng G, Kurtovic L, Agius P, itken E, Sacarlal J,. Wines B, Hogarth P, Rogerson S, Fowkes F, Dobaño C and Beeson J BMC Med 2022
2. Mechanisms of Fc-receptor mediated immunity to malaria sporozoites. Feng, G., Wines, B. D., Kurtovic, L., Chan, J. A., Boeuf, P., Mollard, V., Cozijnsen, A., Drew, D. R., Center, R. J., Marshall, D. L., Chishimba, S., McFadden, G. I., Dent, A. E., Chelimo, K., Boyle, M. J., Kazura, J. W., Hogarth, P. M. and Beeson, J. G. Nat Commun 2021
3. Human immunization with a polymorphic malaria vaccine candidate induced antibodies to conserved epitopes that promote functional antibodies to multiple parasite strains Feng, G., M. J. Boyle, N. Cross, J. A. Chan, L. Reiling, F. Osier, D. Stanisic, I. Mueller, R. F. Anders, J. S. McCarthy, J. S. Richards, and J. G. Beeson J Infect Dis 2018
4. Targets of complement-fixing antibodies in protective immunity against malaria in children Reiling, L., M. J. Boyle, M. T. White, D. W. Wilson, G. Feng, R. Weaver, D. H. Opi, K. E. M. Persson, J. S. Richards, P. M. Siba, F. J. I. Fowkes, E. Takashima, T. Tsuboi, I. Mueller, and J. G. Beeson Nat Commun 2019
5. Induction and decay of functional complement-fixing antibodies by the RTS,S malaria vaccine in children, and a negative impact of malaria exposure Kurtovic, L., P. A. Agius, G. Feng, D. R. Drew, I. Ubillos, J. Sacarlal, J. J. Aponte, F. J. I. Fowkes, C. Dobano, and J. G. Beeson BMC Med 2019
6. Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children Kurtovic, L., M. C. Behet, G. Feng, L. Reiling, K. Chelimo, A. E. Dent, I. Mueller, J. W. Kazura, R. W. Sauerwein, F. J. I. Fowkes, and J. G. Beeson BMC Med 2018
7. CD14(hi)CD16+ monocytes phagocytose antibody- opsonised Plasmodium falciparum infected erythrocytes more efficiently than other monocyte subsets, and require CD16 and complement to do so. J Zhou, G Feng, J Beeson, PM Hogarth, SJ Rogerson, Y Yan, A Jaworowski. BMC Med. 2015
8. Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria. MJ Boyle, L Reiling, G Feng, C Langer, FH Osier, H Aspeling-Jones, YS Cheng, J Stubbs, KK Tetteh, DJ Conway, JS McCarthy, I Muller, K Marsh, RF Anders, JG Beeson. Immunity. 2015
授权专利
James Beeson; Gaoqian Feng ; Liriye KURTOVIC ; Immunogenic compositions, 2022-2-10, WIPO, WO2022027107A1
