李锴，副教授，博士，硕士生导师

科学研究方向

1、脂肪细胞分化障碍的分子机制

2、免疫细胞对脂肪组织代谢稳态的调控

联系方式

通讯：江苏省南京市江宁区龙眠大道101号生物化学与分子生物学系，邮编211166

电话：86869422

电邮：likai87@njmu.edu.cn

简介

李锴，南京医科大学基础医学院生物化学与分子生物学系副教授，硕士生导师。2015年博士毕业于中科院上海营养所，16年进入南京医科大学进行博士后研究并留校任教。以通讯作者在Nature Communications, Cell Reports, Diabetes等期刊发表多篇论文。主要研究方向：1脂肪细胞分化障碍的分子机制；2免疫细胞对脂肪组织代谢稳态的调控。主持国家自然科学基金等各类项目共7项，累计立项金额超210万元。

学术兼职

中国生物物理学会 代谢生物学分会 青年委员

医学分子生物学杂志 青年编委

承担科研课题

(1)   国家自然科学基金面上项目, 32471172, 50万元, 在研, 主持；

(2) 诺和诺德ValidationNN项目, 35万元，在研，主持；

(3)   南京医科大学泰州临床医学院重点研究项目，TZKY20230307，30万元，在研，主持；

(4) 江苏省双创博士（2021年），15万元，结题，主持；

(5)   国家自然科学基金面上项目, 82070897, 57万元, 结题, 主持；

(6) 中国博士后科学基金面上项目, 2017M611869, 5万元, 结题，主持；

(7) 国家自然科学基金青年项目, 81600598, 19万元, 结题, 主持。

代表性论文（#：共同第一作者；*：共同通讯作者）

1, Jiyuan Song^#, Jiahao Ni^#, Kunxin Xie^#, Jinyuan Cao, Wenli Guo, Lei Zhao, Xiaoai Chang, Yu Lu, Peng, Sun, Junjie Yu, Chen Qiu, Shufang Yang*, Wei Liu*, Xiao Han*, Kai Li*; Ets1-dependent Mek-Erk signaling drives adipose tissue Macrophage anti-inflammatory polarization to ameliorates insulin resistance, Cell Reports, 2026 (In publication). （IF：6.9）

2. Chen Qiu^#, Yu Lu^#, Suyang Wu^#, Wenli Guo, Jiahao Ni, Jiyuan Song, Zichao Liu, Xiaoai Chang, Kai Wang, Peng Sun, Qian Zhang*, Shufang Yang*, Kai Li*；Blocking Adipocyte YY1 Decouples Thermogenesis From Beneficial Metabolism by Promoting Spermidine Production, Diabetes, 2025 Mar 1;74(3):295-307. doi: 10.2337/db24-0501. （IF：7.5）

3. Suyang Wu^#, Chen Qiu^#, Jiahao Ni, Wenli Guo, Jiyuan Song, Xingyin Yang, Yulin Sun, Yanjun Chen, Yunxia Zhu, Xiaoai Chang, Peng Sun, Chunxia Wang, Kai Li*, Xiao Han*; M2 macrophages independently promote beige adipogenesis via blocking adipocyte ETS1, Nature Communications, 2024 Feb 22;15(1):1646. （IF：14.7）

4. Kai Li^#, Kaini Zhang^#, Hai Wang^#, Yangyang Wu^#, Nuoqi Chen^#, Jinfeng Chen^#, Chen Qiu, Pengpeng Cai, Min Li, Xiubin Liang, Dongming Su*; Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice, Metabolism-Clinical and Experimental, 2021 Jan:114:154349. （IF：13.9）

5. Jianjin Guo^#, Jinfeng Chen, Wei Ren, Yikun Zhu, Qian Zhao, Kaini Zhang, Dongming Su, Chen Qiu, Wei Zhang, Kai Li*; Citrus flavone tangeretin is a potential insulin sensitizer targeting hepatocytes through suppressing MEK-ERK1/2 pathway, Biochemical and Biophysical Research Communications, 2020 Aug 20;529(2):277-282.（IF：3.3）

6. Kai Li^#; Chen Qiu^#; Peng Sun^#; Dechen Liu; Tijun Wu; Kai Wang; Yuncai Zhou; Xiaoai Chang; Ye Yin; Fang Chen; Yunxia Zhu; Xiao Han; ETS1-Mediated Acetylation of FoxO1 Is Critical for Gluconeogenesis Regulation during Feed-Fast Cycles, Cell Reports, 2019 Mar 12;26(11):2998-3010.（IF：8.1）

7. Kai Li^#, Yuzhong Xiao^#, Junjie Yu, Tingting Xia, Bin Liu, Yajie Guo, Jiali Deng, Shanghai Chen, Chunxia Wang^*, Feifan Guo^*; Liver-specific Gene Inactivation of the Transcription Factor ATF4 Alleviates Alcoholic Liver Steatosis in Mice, Journal of Biological Chemistry, 2016 Aug 26;291(35):18536-46. （IF：4.1）

8. Kai Li^#, Jin Zhang^#, Junjie Yu, Bin Liu, Yajie Guo, Jiali Deng, Shanghai Chen, Chunxia Wang^*, Feifan Guo^*; MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4, Journal of Biological Chemistry, 2015 Mar 27;290(13):8185-95. （IF：4.2）

其他论文（#：共同第一作者；*：共同通讯作者）

1. Meng Shen#, Xinru Yu#, Suyang Wu, Ju Qiu, Ran Wang, Kai Li*, Qian Zhang*; Potential role of dietary whole grains in Alzheimer's disease: bioactive components, mechanistic insights, and epidemiological evidence, Trends in Food Science & Technology, Volume 163, September 2025, 105182. Review. （IF：15.4）

2. Wen Jin#, Gang Chen#, Wei Chen, Guanqun Qiao, Yuequ Deng, Kai Li*, Wei Cai*; Poly-L-Lactic Acid Reduces the Volume of Dermal Adipose Tissue Through its Metabolite Lactate, Aesthetic Plastic Surgery, 2024 Jul 26. doi: 10.1007/s00266-024-04265-x. （IF: 2.0）

3. Qian Zhang#, Qing-qing Zhang#, Shu-qin Dong, Xia Liu, Jing Wei, Kai Li*, Yu Lu*; PDX1 in early pregnancy is associated with decreased risks of gestational diabetes mellitus and adverse pregnancy outcomes, Frontiers in Endocrinology, 2025 May 8:16:1486197. doi: 10.3389/fendo.2025.1486197. （IF: 4.6）

4. Jia Zhang#, Kai Li#, Hao-Ran Sun, Shao-Kun Sun, Ya-Ting Zhu, Yu-Ting Ge, Yu-Xuan Wu, Qin-Yao Zhou, Guan-Ting Li, Xiao-Ai Chang, Peng Sun*, Ying Ding*, Xiao Han*; The heparan sulfate mimetic Muparfostat aggravates steatohepatitis in obese mice due to its binding affinity to lipoprotein lipase, British Journal of Pharmacology, 2023 Jul;180(14):1803-1818.

5. Wen-Yu Song#, Xiao-Han Jiang#, Ying Ding#, Yan Wang, Ming-Xuan Zhou, Yun Xia, Chen-Yu Zhang, Chong-Chong Yin, Chen Qiu, Kai Li*, Peng Sun*, Xiao Han*; Inhibition of heparanase protects against pancreatic beta cell death in streptozotocin-induced diabetic mice via reducing intra-islet inflammatory cell infiltration, British Journal of Pharmacology, 2020 Oct;177(19):4433-4447.

6. Peng Sun#, Kai Li#, Ting Wang, Jun Ji, Yan Wang, Kai-Xian Chen, Qi Jia, Yi-Ming Li*, He-Yao Wang*; Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes, Journal of Agricultural and Food Chemistry, 2019 Aug 14;67(32):8839-8846.

课题组研究生

研究生招生方向：2型糖尿病代谢失衡与胰岛细胞功能。

本课题组欢迎有志于肥胖、代谢紊乱领域研究的本科毕业生报考!

联系邮箱：Likai87@njmu.edu.cn