杨芬 医学博士 副教授 硕士研究生导师
科学研究方向 RNA修饰/LncRNA/R-loop与肿瘤表观调控
联系方式
通讯：江苏省南京市江宁区龙眠大道101号学海楼，邮编211166
简介
2012年毕业于中山大学肿瘤防治中心（华南肿瘤学国家重点实验室），获肿瘤学博士学位，同年9月进入南京医科大学基础医学院工作。主要研究方向为RNA生物学与肿瘤表观调控，重点关注R-loop和RNA修饰对基因表达的调控，致力于发现R-loop、m6A和m5C的新阅读蛋白及其对肿瘤发生或发展的调控。先后主持国家自然科学基金青年项目、面上项目和江苏省自然科学基金面上项目，发表科研论文30余篇，其中以第一作者或通讯作者（含共同）在Nature Communication, Molecular Cancer, Cell Death & Disease，Journal of Molecular Biology和Life Sciences等国际知名期刊发表科研论文近20篇，发表教学论文4篇，参编教材2部。欢迎热爱科学研究、愿意以科研为业的同学报考该方向研究生。
教育背景及工作经历
2019-至今 南京医科大学生物化学与分子生物学系 副教授
2019-2021 美国德州大学MD安德森肿瘤中心 Research Scientist
2012-2019 南京医科大学生物化学与分子生物学系讲师
承担科研课题
1. 国家自然科学基金-面上项目，32270649，m6A阅读蛋白SF3B4调控MAT2A可变剪接促进肝癌发生的机制研究，2023/1-2016/12, 54万元，在研，主持。
2. 江苏省自然科学基金-面上项目，BK20181365，血小板外泌体源性lncRNA LINC00355促进胃癌转移的分子机制研究，2018/7-2021/6，10万元，已结题，主持。
3. 国家自然科学基金-青年项目，31401094，长链非编码RNA ANRIL下调PLZF表达介导胃癌细胞上皮-间充质转化的机制研究，2015/1-2017/12，26万元，已结题，主持。
代表性论文
1. Wenjing Zhao, Yunan Zhang, Wei Zhang, Yiming Sun, Beiyao Zheng, Junbin Wang, Yazhou Gu, Junxia, Qi, Juxue, Li, Xuejun Wang*, Jinfei Chen* and Fen Yang*. Exosomal LINC00355 promotes the malignant progression of gastric cancer through histone deacetylase HDAC3-mediated TP53INP1 transcriptional inhibition. Life Sciences. 2023; 315:121387.
2. Zhao, Fan#; Deng, Ya fang#; Yang, Fen#; Yan, Yan; Feng, Fan; Peng, Bo; Gao, Juntao; Bedford, Mark T.; Li, Haitao ; Molecular Basis for SPINDOC-Spindlin1 Engagement and Its Role in Transcriptional Attenuation, Journal of Molecular Biology, 2023, Nov 15:168371.
3. Fen Yang, Jianji Chen, Bin Liu, Guozhen Gao, Manu Sebastian, Collene Jeter, Jianjun Shen, Maria D Person and Mark T Bedford*. SPINDOC binds PARP1 to facilitate PARylation. Nature Communications. 2021;12(1):6362.
4. Weiyan Zou, Yan Yang, Rongsheng Zheng, Zishu Wang, Huihui Zeng, Zhelong Chen, Fen Yang* and Junbin Wang*. Association of CD44 and CD24 phenotype with lymph node metastasis and survival in triple-negative breast cancer. Int J Clin Exp Pathol 2020;13(5):1008-1016.
5. Ji Wang, Jinyu Sun, Fen Yang*. The role of long non‑coding RNA H19 in breast cancer (Review). Oncology letters 2020; 19(1):7-16.
6. Jun-Bin Wang# , Yan Jin#, Peng Wu, Yang Liu, Wen-Jing Zhao, Jin-Fei Chen, Wei Deand Fen Yang*.Methylation of tumor suppressor PLZF by long noncoding RNA
ANRIL suppresses proliferation and epithelial mesenchymal transformation of gastriccancer cells. Oncology Reports, 2019;41(2):1007-1018.
7. Yan Jin#, Kun Zhou#, Wen-Jing Zhao, Rong-Bo Han, Xin-Ying Huo, Fen Yang*, Jin-Fei Chen*. Clinicopathological and prognostic significance of metastasis -associated in colon cancer-1 (MACC1) in gastric cancer: a meta-analysis. TheInternational Journal of Biological Markers, 2019; 34(1):27-32.
8. Jin-Fei Chen#, Peng Wu#, Rui Xia, Jian Yang, Xin-Ying Huo, Dong-Ying Gu, Cui-Ju Tang, Wei De and Fen Yang*. STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy. Molecular cancer, 2018;17(1):6.
9. Yan Jin#, Peng Wu#, Wen-Jing Zhao, Xuejun Wang, Jian Yang, Xin-Ying Huo, Jin-Fei Chen, Wei De and Fen Yang*. Long noncoding RNALINC00165-induced by STAT3 exerts oncogenic properties via interaction with Polycomb Repressive Complex 2 to promote EMT in gastric cancer. Biochemical and Biophysical Research Communications, 2018;507(1-4):223-230.
10. Jian-Hua Zhu#, Qiang Huo#, Ming Xu, Fen Yang, Yang Li, Hui-Hui Shi, Yi-Min Niu* and Yang Liu*. Bortezomib-catechol conjugated prodrug micelles: combining bone targeting and aryl boronate-based pH-responsive drug release for cancer bone- metastasis therapy. Nanoscale, 2018; 10:18387-18397.
