杨芬

发布者:张愉悦发布时间:2020-05-15浏览次数:1624

 杨芬,副教授,医学博士 

 科学研究方向

 肿瘤表观调控的分子机制

 联系方式

 通讯:江苏省南京市江宁区龙眠大道101号学海楼,邮编211166

 电话:025-86869431

 电邮:yangfen@njmu.edu.cn



简介

2012年毕业于中山大学肿瘤防治中心(华南肿瘤学国家重点实验室),获肿瘤学博士学位,20129月进入南京医科大学基础医学院工作。主要研究方向为肿瘤表观调控与信号转导的分子机制,主持国家自然科学基金青年项目和江苏省自然科学基金面上项目各1项,在国际期刊发表科研论文10余篇,发表教学论文2篇。

 

教育背景及工作经历

2009-2012  中山大学肿瘤防治中心 博士

2012-2019  南京医科大学生物化学与分子生物学系讲师

2019-2021  美国德州大学MD安德森肿瘤肿瘤中心   博士后

2019-至今   南京医科大学生物化学与分子生物学系  副教授

 

奖项及荣誉

2016南京医科大学青年教师讲课比赛二等奖和最佳教案奖

2016年全国高校医学类微课教学比赛三等奖

2019年全国高校医学类微课教学比赛三等奖

 

学术兼职

江苏省细胞发育学会会员

中国抗癌协会会员

 

承担科研课题

1. 江苏省自然科学基金面上项目,BK20181365,血小板外泌体源性lncRNA LINC00355促进胃癌转移的分子机制研究,2018/7-2021/610万元,在研,主持。

2. 国家自然科学基金青年项目,31401094,长链非编码RNA ANRIL下调PLZF表达介导胃癌细胞上皮-间充质转化的机制研究,2015/1-2017/1226万元,已结题,主持。

 

近五年代表性论文、专利

1. Ji Wang#, Jin-Yu Sun#, Fen Yang*. The role of long noncoding RNA H19 in breast cancer (Review). Oncology Letters,2020;19:7-16.

2. Jun-Bin Wang# , Yan Jin#, Peng Wu, Yang Liu, Wen-Jing Zhao, Jin-Fei Chen, Wei De and Fen Yang*.Methylation of tumor suppressor PLZF by long noncoding RNA ANRIL suppresses proliferation and epithelial mesenchymal transformation of gastric cancer cells. Oncology Reports, 2019;41(2):1007-1018.

3. Yan Jin#, Kun Zhou#, Wen-Jing Zhao, Rong-Bo Han, Xin-Ying Huo, Fen Yang*, Jin-Fei Chen*. Clinicopathological and prognostic significance of metastasis-associated in colon cancer-1 (MACC1) in gastric cancer: a meta-analysis. The International Journal of Biological Markers, 2019; 34(1):27-32.

4. Jin-Fei Chen#, Peng Wu#, Rui Xia, Jian Yang, Xin-Ying Huo, Dong-Ying Gu, Cui-Ju Tang, Wei De and Fen Yang*. STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy. Molecular cancer, 2018;17(1):6.

5. Yan Jin#, Peng Wu#, Wen-Jing Zhao, Xuejun Wang, Jian Yang, Xin-Ying Huo, Jin-Fei Chen, Wei De and Fen Yang*. Long noncoding RNA LINC00165-induced by STAT3 exerts oncogenic properties via interaction with Polycomb Repressive Complex 2 to promote EMT in gastric cancer. Biochemical and Biophysical Research Communications, 2018;507(1-4):223-230.

6. Fen Yang#*, Xiao Yan Tang#, Hao Liu and Zhi-Wen Jiang.Inhibition of Mitogen-Activated Protein Kinase Signaling Pathway Sensitizes Breast Cancer Cells to Endoplasmic Reticulum Stress-Induced Apoptosis.Oncology Reports, 2016; 35(4):2113-20

7. Fen Yang#, Rong Deng#, Xiao-Jun Qian#, Shao-Hua Chang, Xiao-Qi Wu, Juan Qin, Gong-Kan Feng, Ke Ding* and Xiao-Feng Zhu*. Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer. Cell Death & Disease 2014; 5:e1114.

8. Jian-Hua Zhu#, Qiang Huo#,  Ming Xu,  Fen Yang,  Yang Li,  Hui-Hui Shi,  Yi-Min Niu* and  Yang Liu*. Bortezomib-catechol conjugated prodrug micelles: combining bone targeting and aryl boronate-based pH-responsive drug release for cancer bone-metastasis therapy.Nanoscale, 2018;10, 18387-18397.

9. Yan-Wen Liu, Rui Xia, Kai Lu, Min Xie, Fen Yang, Min Sun , Wei De*, Cai-Lian Wang*, Guo-Zhong Ji*. LincRNAFEZF1-AS1 represses p21 expression to promote gastric cancer proliferation through LSD1-Mediated H3K4me2 demethylation. Molecular Cancer. 2017;16(1):39.

10. Xuan Li#, Xiao-Qi Wu#, Rong Deng#, Dan-Dan Li, JunTang , Wen-Dan Chen, Jing-Hong Chen, JiaoJi, Lin Jiao, Shan Jiang, Fen Yang, Gong-Kan Feng, Senthilkumar Ravichandran, Fei Yue, Hai-Liang Zhang, Rui-Yan Wu, Yan Yu,  Xue-Lian Xu, Jia Mai, Zhi-Ling Li, Xiao-Dan Peng, Yun Huang, Xiang Huang, Ning-Fang Ma, Qian Tao, Yi-Xin Zeng, Xiao-Feng Zhu*. CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation. Nature Communication, 2017;8(1)1159~1159.

11. Juan Qin#, Jiao Ji#, Rong Deng#, Jun Tang, Fen Yang, Gong-Kan Feng, Wen-Dan Chen, Xiao-Qi Wu, Xiao-Jun Qian, Ke Ding, Xiao-Feng Zhu*. DC120, a novel AKT inhibitor, preferentially suppresses nasopharyngeal carcinoma cancer stem-like cells by downregulating Sox2. Oncotarget, 2015;6(9):6944~6958.

12. Xiao-jun Qian#, Yun-tian Li#, Yan Yu, Fen Yang, Rong Deng, Jiao Ji, Lin Jiao, Xuan Li, Rui-Yan Wu, Wen-Dan Chen, Gong-Kan Feng, Xiao-Feng Zhu*.Inhibition of DNA methyltransferase as a novel therapeutic strategy to overcome acquired resistance to dual PI3K/mTOR inhibitors. Oncotarget. 2015; 6:5134-5146.