汪秀星，教授，博士，博士生导师，细胞生物学系科研副主任
科学研究方向
胶质瘤干细胞及其微环境调控
联系方式
通讯：江苏省南京市江宁区龙眠大道101号细胞生物学系，邮编211166
电话：025-86869340
电邮：xiuxingwang@njmu.edu.cn
简介
汪秀星，博士，教授，博士生导师，入选国家级高层次青年人才，江苏省特聘教授。南京医科大学基础医学院细胞生物学系/国家卫生健康委员会抗体技术重点实验室教授。 现为中国神经科学学会神经肿瘤分会常务理事、中国细胞生物学学会肿瘤细胞生物学分会委员、中国细胞生物学会医学细胞生物学分会委员、中国医师协会脑胶质瘤专业委员会基础与转化委员、江苏省细胞与发育生物学会理事。以通讯作者和第一作者在Cancer Discovery (2021), Science Translational Medicine (2019, 2024a, 2024b), Nature Communications (2022, 2023), Cell Death & Differentiation (2024), Clinical Cancer Research (2023), Neuro-Oncology (2023a, 2023b), Cancer Research (2017, 2022), Cancer Letters (2023), Cell Stem Cell (2018), Nature Neuroscience (2017), Journal of Experimental Medicine (2013, 2019)上发表论文。同时，以共同作者的在Nature, Cell, Nature Medicine, Cancer Cell, Cell Stem Cell, Cancer Discovery, Nature Cancer, Science Translational Medicine, Molecular Cell, Journal of Clinical Investigation等杂志上发表论文。本课题组主要聚焦于从分子、细胞、动物、病人层面深入研究胶质瘤干细胞代谢与免疫微环境，并探讨其功能及其调节机制，有针对性地开展针对胶质瘤干细胞靶向精准治疗研究，来探究精准治疗在GBM治疗中的意义。
教育背景及工作经历
2008.09-2013.08 南京大学模式动物研究所 博士
2014.11-2017.07 美国克利夫兰医学中心Lerner研究所 博士后
2017.08-2018.09 美国加州大学圣地亚哥分校医学系 博士后
2018.10-2019.06 美国加州大学圣地亚哥分校医学系 助理项目科学家
2019.9-至今 南京医科大学基础医学院细胞生物学系 教授，博士生导师
学术兼职
中国神经科学学会神经肿瘤分会常务委员
中国细胞生物学会肿瘤细胞生物学分会委员
中国细胞生物学会医学细胞生物学会委员
中国医师协会脑胶质瘤专业委员会基础与转化委员
江苏省细胞与发育生物学会理事
承担科研课题
1. 肿瘤干细胞微环境“国家级高层次青年人才”2020-2023，主持
2. 肿瘤干细胞微环境“江苏省特聘教授” 2020-2023，主持
3. 国家自然基金面上项目， CXCL8和C1ORF61对胶质母细胞瘤异质性调控机制及联合靶向治疗的研究 （81570499），2021-2024，在研，主持
4. 肿瘤个体化医学省部共建协同创新中心恒瑞医药临床研究基金，TNFAIP6维持胶质瘤干细胞炎性压力下重塑微环境的机制研究，2024/10-2026/09，在研，主持
代表性论文
1. Fanying Li#, Kailin Yang#, Xinya Gao#, Maolei Zhang#, Danling Gu#, Xujia Wu, Chenfei Lu, Qiulian Wu, Deobrat Dixit, Ryan C. Gimple, Yongping You, Stephen C. Mack, Yu Shi, Tiebang Kang, Sameer A. Agnihotri, Michael D. Taylor, Jeremy N. Rich*, Nu Zhang*, Xiuxing Wang*. A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice. (Corresponding author, Science Translational Medicine, Cover Story) 2024;16(767):eadk9524.
2. Deobrat Dixit, Briana C. Prager, Ryan C. Gimple, Qiulian Wu, Yang Wang, Reilly L. Kidwell, Hui Xian Poh, Leo J. Y. Kim, Zhixin Qiu, Qi Xie, Kristoffer Vitting-Seerup, Shruti Bhargava, Zhen Dong, Li Jiang, Zhe Zhu, Petra Hamerlik, Samie R. Jaffrey, Crystal Zhao*, Xiuxing Wang*, Jeremy N. Rich*. The RNA m6A reader YTHDF2 maintains oncogenes expression and is a targetable dependency in glioblastoma stem cells. (Co-corresponding author, Cancer Discovery)2021;11(2):480-499.
3. Daqi Li #, Xiefeng Wang #, Kexin Chen #, Danyang Shan #, Gaoyuan Cui #, Wei Yuan, Qiankun Lin, Ryan C Gimple, Deobrat Dixit, Chenfei Lu, Danling Gu, Hao You, Jiancheng Gao, Yangqing Li, Tao Kang, Junlei Yang, Hang Yu, Kefan Song, Zhumei Shi, Xiao Fan, Qiulian Wu, Wei Gao, Zhe Zhu, Jianghong Man, Qianghu Wang, Fan Lin, Weiwei Tao, Stephen C Mack, Yun Chen, Junxia Zhang, Chaojun Li, Nu Zhang, Yongping You, Xu Qian, Kailin Yang*, Jeremy N Rich*, Qian Zhang*, Xiuxing Wang*. IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages. (Corresponding author, Cell Death & Differentiation)2024;31(6):738-752.
4. Wei Yuan#, Qian Zhang#, Danling Gu#, Chenfei Lu#, Deobrat Dixit, Ryan C. Gimple, Yisu Gao, Jiancheng Gao, Daqi Li, Danyang Shan, Lang Hu, Lu Li, Yangqing Li, Hao You, Linping Yan, Kexin Chen, Ningwei Zhao, Chuanhai Xu, Jianyun Lan, Dong Liu, Junxia Zhang, Zhumei Shi, Qiulian Wu, Kailin Yang, Linjie Zhao, Zhixin Qiu,, Deguang Lv, Wei Gao, Hui Yang, Fan Lin, Qianghu Wang, Jianghong Man, Chaojun Li, Weiwei Tao, Sameer Agnihotri, Xu Qian, Stephen C. Mack, Nu Zhang, Yongping You, Jeremy N. Rich*, Guan Sun*, Xiuxing Wang*.Dual role of CXCL8 in maintaining the mesenchymal state of glioblastoma stem cells and M2-like tumor-associated macrophages. (Corresponding author, Clinical Cancer Research). 2023;29(18):3779-3792.
5. Danling Gu#, Fengqi Zhou#, Hao You#, Jiancheng Gao#, Tao Kang, Deobrat Dixit, Qiulian Wu, Kailin Yang, Danyang Shan, Xiao Fan, Wei Yuan, Qian Zhang, Chenfei Lu, Daqi Li, Ningwei Zhao, Zhumei Shi, Wei Gao, Fan Lin, Jianghong Man, Qianghu Wang, Xu Qian, Stephen C Mack, Weiwei Tao, Sameer Agnihotri, Nu Zhang, Yongping You, Jeremy N Rich*, Junxia Zhang*, Xiuxing Wang*. SREBP2 maintains glioblastoma stem cells through keeping the balance between cholesterol biosynthesis and uptake. (Corresponding author, Neuro-Oncology) 2023;25(9):1578-1591.
6. Daqi Li#, Qian Zhang#, Lu Li, Kexin Chen, Junlei Yang, Deobrat Dixit, Ryan C Gimple, Chenfei Lu, Lang Hu, Jiancheng Gao, Danyang Shan, Yangqing Li, Junxia Zhang, Zhumei Shi, Danling Gu, Wei Yuan, Qiulian Wu, Kailin Yang, Linjie Zhao, Zhixin Qiu, Deguang Lv, Wei Gao, Hui Yang, Fan Lin, Qianghu Wang, Jianghong Man, Chaojun Li, Weiwei Tao, Sameer Agnihotri, Xu Qian Yu Shi, Yongping You, Nu Zhang*, Jeremy N Rich*, Xiuxing Wang*.b2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-like Polarization of Tumor-Associated Macrophages. (Corresponding author, Cancer Research)2022;82(18):3321-3334.
7. Danling Gu#, Hao You#, Jiancheng Gao#, Yongping You, Jeremy N Rich*, Junxia Zhang*, Xiuxing Wang*. Reply to Targeting cholesterol homeostasis through inhibiting: An Achilles' heel for glioblastoma? (Corresponding author, Neuro-Oncology) 2023;25(11):2103-2104.
8. Jianxing Yin#, Xin Ge#, Fangshu Ding#, Liuguijie He, Keying Song, Zhumei Shi, Zehe Ge, Junxia Zhang, Jing Ji, Xiefeng Wang, Ningwei Zhao, Chuanjun Shu, Fan Lin, Qianghu Wang, Qigang Zhou, Yuandong Cao, Wentao Liu, Dan Ye, Jeremy N. Rich, Xiuxing Wang*, Yongping You*, Xu Qian*. Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly pathway. (Co-corresponding author, Science Translational Medicine) 2024;16(739):eadg5553.
9. Jian Zhong#, Xujia Wu#, Yixin Gao#, Junju Chen#, Maolei Zhang, Huangkai Zhou, Jia Yang, Feizhe Xiao, Xuesong Yang, Nunu Huang, Haoyue Qi, Xiuxing Wang*, Fan Bai*, Yu Shi* & Nu Zhang*. Circular RNA encoded MET variant promotes glioblastoma tumorigenesis. (Co-corresponding author, Nature Communications) 2023;14(1):4467.
10. Xiao Fan#, Jintan Li#, Bin Huang#, Hongyu Lu, Chenfei Lu, Minhong Pan, Xiefeng Wang, Hongjian Zhang, Yongping You, Xiuxing Wang*, Qianghu Wang*, Junxia Zhang*. Noninvasive radiomics model reveals macrophage infiltration in glioma. (Co-corresponding author, Cancer Letters) 2023;573:216380.
11. Jian Zhong#, Xuesong Yang#, Junju Chen#, Kejun He#, Xinya Gao, Xujia Wu, Maolei Zhang, Huangkai Zhou, Feizhe Xiao, Lele An, Xiuxing Wang*, Yu Shi*, Nu Zhang*. Circular EZH2-Encoded EZH2-92aa Mediates Immune Evasion in Glioblastoma via Inhibition of Surface NKG2D Ligands. (Co-corresponding author, Nature Communications) 2022;13(1):4795.
12. Xiuxing Wang, Briana C. Prager , Qiulian Wu, Leo J. Y. Kim, Ryan C. Gimple, Yu Shi, Kailin Yang, Andrew Morton, Wenchao Zhou, Zhe Zhu,Elisabeth Anne Adanma Obara,Tyler E. Miller, Anne Song, Sisi Lai, Christopher G. Hubert, Xun Jin, Zhi Huang, Xiaoguang Fang, Deobrat Dixit, Weiwei Tao, Kui Zhai, Cong Chen, Zhen Dong, Guoxin Zhang, Stephen M. Dombrowski, Petra Hamerlik,Stephen C. Mack, Shideng Bao, Jeremy N. Rich: Reciprocal signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression. Cell Stem Cell 2018;22(4):514-528.e5.
13. Xiuxing Wang#, Kailin Yang#, Qi Xie, Qiulian Wu, Stephen C Mack, Yu Shi, Leo J Y Kim, Briana C Prager, William A Flavahan, Xiaojing Liu, Meromit Singer, Christopher G Hubert, Tyler E Miller, Wenchao Zhou, Zhi Huang, Xiaoguang Fang, Aviv Regev, Mario L Suv, Tae Hyun Hwang, Jason W Locasale, Shideng Bao, Jeremy N Rich*. Purine synthesis promotes maintenance of brain tumor initiating cells in glioma.Nature Neuroscience 2017;20(5):661-673.
14. Xiuxing Wang#, Kailin Yang#, Qiulian Wu, Leo J.Y. Kim, Andrew R. Morton, Ryan C. Gimple, Briana C. Prager, Yu Shi, Wenchao Zhou, Shruti Bhargava, Zhe Zhu, Li Jiang, Weiwei Tao, Zhixin Qiu, Linjie Zhao, Guoxing Zhang, Xiqing Li, Sameer Agnihotri, Paul S. Mischel, Stephen C. Mack, Shideng Bao, Jeremy N. Rich*. Targeting Pyrimidine Synthesis Accentuates Molecular Therapy Response in Glioblastoma Stem Cells. Science Translational Medicine(Cover Story).2019;11(504): eaau4972.
15. Xiuxing Wang, zhi huang, Qiulian Wu, Briana C Prager, Stephen C Mack, Kailin Yang, Leo J. Y. Kim, Ryan C Gimple, Yu Shi, Sisi Lai, Qi Xie, Tyler E. Miller, Christopher G Hubert, Anne Song, Zhen Dong, Wenchao Zhou, Xiaoguang Fang, Zhe Zhu, Vaidehi Mahadev, Shideng Bao, Jeremy N. Rich* MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells. Cancer Research 2017;77(18):4947-4960.
16. Stephen C. Mack#, Irtisha Singh#, Xiuxing Wang#, Rachel Hirsch, Quilian Wu, Jean A.Bernatchez, Zhe Zhu, Ryan C. Gimple, Leo J.Y. Kim, Andrew Morton, Sisi Lai, Zhixin Qiu, Rosie Villagomez, Briana C. Prager, Kelsey C. Bertrand, Clarence Mah, Wenchao Zhou, Christine Lee, Gene H. Barnett, Michael A. Vogelbaum, Andrew E. Sloan, Lukas Chavez, Shideng Bao, Peter C. Scacheri, Jair L. Siqueira-Neto, Charles Y. Lin*, Jeremy N. Rich*. Chromatin Landscapes Reveal Developmentally Encoded Transcriptional States That Define Glioblastoma. Journal of Experimental Medicine2019;216(5):1071-1090.
17. Xiu-Xing Wang, Pu Ying, Fan Diao, Qiang Wang, Dan Ye, Chen Jiang, Ning Shen, Na Xu, Wei-Bo Chen, Shan-Shan Lai, Shan Jiang, Xiao-Li Miao, Jin Feng, Wei-Wei Tao, Ning-Wei Zhao, Bing Yao, Zhi-Peng Xu, Hai-Xiang Sun, Jian-Min Li, Jia-Hao Sha, Xing-Xu Huang, Qing-Hua Shi, Hong Tang, Xiang Gao, Chao-Jun Li. Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection. Journal of Experimental Medicine2013;210(8):1559-74.
18. Deguan Lv, Deobrat Dixit, Andrea F Cruz, Leo J Y Kim, Likun Duan, Xin Xu, Qiulian Wu, Cuiqing Zhong, Chenfei Lu, Zachary C Gersey, Ryan C Gimple, Qi Xie, Kailin Yang, Xiaojing Liu, Xiaoguang Fang, Xujia Wu, Reilly L Kidwell, Xiuxing Wang, Shideng Bao, Housheng H He, Jason W Locasale, Sameer Agnihotri, Jeremy N Rich. Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2. Cell Metabolism, 2024; S1550-4131(24) 00396-6.
19. Jian Zhong, Xudong Xing, Yixin Gao, Lei Pei, Chenfei Lu, Huixin Sun, Yanxing Lai, Kang Du, Feizhe Xiao, Ying Yang, Xiuxing Wang, Yu Shi, Fan Bai, Nu Zhang. Distinct roles of TREM2 in central nervous system cancers and peripheral cancers. Cancer Cell, 2024;42(6):968-984.e9.
20. Mengdie Li, Zhixiang Zhang, Liuguijie He, Xiefeng Wang, Jianxing Yin, Xiuxing Wang, Yongping You, Xu Qian, Xin Ge, Zhumei Shi. SMYD2 induced PGC1alpha methylation promotes stemness maintenance of glioblastoma stem cells. Neuro-Oncology, 2024;26(9):1587-1601.
21. Min Wu, Tingting Wang, Nan Ji, Ting Lu, Ran Yuan, Lingxiang Wu, Junxia Zhang, Mengyuan Li, Penghui Cao, Jiarui Zhao, Guanzhang Li, Jianyu Li, Yu Li, Yujie Tang, Zhengliang Gao, Xiuxing Wang, Wen Cheng, Ming Ge, Gang Cui, Rui Li, Anhua Wu, Yongping You, Wei Zhang, Qianghu Wang, Jian Chen. Multi-omics and pharmacological characterization of patient-derived glioma cell lines. Nature Communications, 2024;15(1):6740.
22. Zehe Ge, Miao Xu, Yuqian Ge, Guang Huang, Dongyin Chen, Xiuquan Ye, Yibei Xiao, Hongyu Zhu, Rong Yin, Hua Shen, Gaoxiang Ma, Lianwen Qi, Guining Wei, Dongmei Li, Shaofeng Wei, Meng Zhu, Hongxia Ma, Zhumei Shi, Xiuxing Wang, Xin Ge, Xu Qian. Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation. Cell Reports, 2023;42(11):113417.
23. Deguan Lv, Cuiqing Zhong, Deobrat Dixit, Kailin Yang, Qiulian Wu, Bhaskar Godugu, Briana C Prager, Guofeng Zhao, Xiuxing Wang, Qi Xie, Shideng Bao, Chuan He, Dieter Henrik Heiland, Michael G Rosenfeld, Jeremy N Rich. EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma. Molecular Cell, 2023; S1097-2765(23)00862-6.
24. Jianxing Yin, Xiefeng Wang, Xin Ge, Fangshu Ding, Zhumei Shi, Zehe Ge, Guang Huang, Ningwei Zhao, Dongyin Chen, Junxia Zhang, Sameer Agnihotri, Yuandong Cao, Jing Ji, Fan Lin, Qianghu Wang, Qigang Zhou, Xiuxing Wang, Yongping You, Zhimin Lu, Xu Qian. Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas. Nature Communications, 2023;14(1):5913.
25. Handong Sun, Lishen Zhang, Zhonglin Wang, Danling Gu, Mengyan Zhu, Yun Cai, Lu Li, Jiaqi Tang, Bin Huang, Bakwatanisa Bosco, Ning Li, Lingxiang Wu, Wei Wu, Liangyu Li, Yuan Liang, Lin Luo, Quanzhong Liu, Yanhui Zhu, Jie Sun, Liang Shi, Tiansong Xia, Chuang Yang, Qitong Xu, Xue Han, Weiming Zhang, Jianxia Liu, Dong Meng, Hua Shao, Xiangxin Zheng, Shuqin Li, Hua Pan, Jing Ke, Wenying Jiang, Xiaolan Zhang, Xuedong Han, Jian Chu, Hongyin An, Juyan Ge, Chi Pan, Xiuxing Wang, Kening Li, Qianghu Wang, Qiang Ding. Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer. Nature Communications, 2023;14(1):5590.
26. Weiwei Tao, Hong Lei, Wenlong Luo, Zhi Huang, Peng Ling, Mengyue Guo, Lihao Wan, Kui Zhai, Qian Huang, Qiulian Wu, Shutong Xu, Liang Zeng, Xiuxing Wang, Zhiqiang Dong, Jeremy N Rich, Shideng Bao. Novel INHAT repressor drives glioblastoma growth by promoting ribosomal DNA transcription in glioma stem cells. Neuro-Oncology, 2023; 25(8):1428-1440.
27. Nunu Huang, Zhipeng Chen, Xuesong Yang, Yixin Gao, Jian Zhong, Yan Li, Feizhe Xiao, Xiuxing Wang, Yu Shi, Nu Zhang. Upstream Open Reading Frame-encoded MP31 Disrupts the Mitochondrial Quality Control Process and Inhibits Tumorigenesis in Glioblastoma. Neuro-Oncology 2023;25(11):1947-1962.
28. Zengpanpan Ye, Xiaolin Ai, Kailin Yang, Zhengnan Yang, Fan Fei, Xiaoling Liao, Zhixin Qiu, Ryan C Gimple, Huairui Yuan, Hao Huang, Yanqiu Gong, Chaoxin Xiao, Jing Yue, Liang Huang, Olivier Saulnier, Wei Wang, Peidong Zhang, Lunzhi Dai, Xin Wang, Xiuxing Wang, Young Ha Ahn, Chao You, Jianguo Xu, Xiaoxiao Wan, Michael D Taylor, Linjie Zhao, Jeremy N Rich, Shengtao Zhou. Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma. Cancer Discovery, 2023;13(4):974-1001.
29. Mengjie Zhao, Yanhui Li, Chenfei Lu, Fangshu Ding, Miao Xu, Xin Ge, Mengdie Li, Zhen Wang, Jianxing Yin, Junxia Zhang, Xiefeng Wang, Zehe Ge, Hong Xiao, Yong Xiao, Hongyi Liu, Wentao Liu, Yuandong Cao, Qianghu Wang, Yongping You, Xiuxing Wang, Kun Yang, Zhumei Shi, Xu Qian. PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma. Cancer Research 2023;83(7):1094-1110.
30. Min Wu, Lingxiang Wu, Wei Wu, Mengyan Zhu, Jianyu Li, Ziyu Wang, Jie Li, Rong Ding, Yuan Liang, Liangyu Li, Tingting Zhang, Bin Huang, Yun Cai, Kening Li, Lu Li, Rui Zhang, Baoli Hu, Fan Lin, Xiuxing Wang, Siyuan Zheng, Jian Chen, Yongping You, Tao Jiang, Junxia Zhang, Hongshan Chen, Qianghu Wang. Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow-Derived Macrophages. Cancer Research2023;83(5):771-785.
