简介

卢应梅，教授，南京医科大学博士研究生导师，于Tohoku Univesity（日本）获得博士学位。长期从事脑血管病及神经精神疾病机制研究。近5年发表代表性SCI论文40余篇。作为通讯作者研究论文发表在Neuron、J Clin Invest、Molecular Psychiatry、J Exp Med、Signal Transduct Target Ther、J Pineal Res等国际刊物。兼任日本Tohoku University客座教授；中国神经学会脑血管功能与疾病分会副主任委员；中国微循环学会微循环药物研究专委会副主任委员；获得教育部自然科学奖一等奖，作为项目负责人承担国家自然科学基金重点项目和科技部重大项目多项。

研究领域：

采用环路追踪技术、双光子成像技术、膜片钳记录、在体多通道多脑区电生理记录及各种基因调控技术，开展：

  1.     认知功能障碍的发病机制和新药研发（AD和血管性痴呆）；

  2.     自闭症、焦虑及抑郁症等精神疾病的发病机制和新药研发。

近五年承担科研课题（主持人）：

①.   国家自然科学基金重点国际(地区)合作研究项目，W2411078，2025.01-2029.12，244万，主持

②.   2030科技创新-脑科学与类脑研究， 2021ZD0204002，2021-12-01 至 2026-11-30, 864万, 在研, 主持

③.   科技部重大研发计划，022YFE0108600，2022-9-30至2025-8-31，300万，主持

近五年的发表的代表作（以通讯作者发表）：

①.   Luo YF, Lu L, Song HY, Xu H, Zheng ZW, Wu ZY, Jiang CC, Tong C, Yuan HY, Liu XX, Chen X, Sun ML, Tang YM, Fan HY, Han F* , Lu YM*. Divergent projections of the prelimbic cortex mediate autism- and anxiety-like behaviors. Mol Psychiatry. 2023;28(6):2343-2354.

②.   Lu Y, Chen X, Liu X, Shi Y, Wei Z, Feng L, Jiang Q, Ye W, Sasaki T, Fukunaga K, Ji Y, Han F , Lu YM*. Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction. Autophagy. 2023;19(6):1803-1820.

③.Liu XX, Chen XH, Zheng ZW, Jiang Q, Li C, Yang L, Chen X, Mao XF, Yuan HY, Feng LL, Jiang Q, Shi WX, Sasaki T, Fukunaga K, Chen Z, Han F, Lu YM*.BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination.Signal Transduct Target Ther. 2022 Jun 1;7(1):170.

④.Chen DY, Sun NH, Chen X, Gong JJ, Yuan ST, Hu ZZ, Lu NN, Körbelin J, Fukunaga K, Liu QH*,Lu YM*, Han F*. Endothelium-derived semaphorin 3G attenuates ischemic retinopathy by coordinating β-catenin-dependent vascular remodeling.J Clin Invest. 2021;131(4):e135296.

⑤.Sun M, Mao XF, Li ZM, Zhu ZH, Gong DM, Lu L, Chen X, Zhang Y, Fukunaga K, Ji Y, Gu AH*, Lu YM*, Han F*. Endothelial peroxynitrite causes disturbance of neuronal oscillations by targeting caspase-1 in the arcuate nucleus.Redox Biol. 2021;47:102147.

⑥.Liu XX, Yang L, Shao LX, He Y, Wu G, Bao YH, Lu NN, Gong DM, LuYP, CuiTT, Sun NH, Chen DY, ShiWX, FukunagaKJ,ChenHS, ChenZ^*, HanF^*, Lu YM*. Endothelial Cdk5 Deficit Leads to the Development of Spontaneous Epilepsy Through CXCL1/CXCR2-Mediated Reactive Astrogliosis.J Exp Med. 2020;217(1):e20180992.

⑦.Tan C, Lu NN, Wang CK, Chen DY, Sun NH, Lyu H, Körbelin J, Shi WX, Fukunaga K, Lu YM*, Han F*. Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4.Neuron. 2019;101:920-937.

⑧.Shao LX, Jiang Q, Liu XX, Gong DM, Yin YX, Wu G, Sun NH, Wang CK, Chen QZ, Yu C, Shi WX, Fan HY, Fukunaga K, Chen Z*, Lu YM*, Han F*. Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons.Mol Psychiatry.2019;24(10):1461-1477.

⑨.Wang CK, Ahmed MM, Jiang Q, Lu NN, Tan C, Gao YP, Mahmood Q, Chen DY, Fukunaga K, Li M, Chen Z, Wilcox CS, Lu YM*, Qin ZH*, Han F*. Melatonin ameliorates hypoglycemic stress-induced brain endothelial tight junction injury by inhibiting protein nitration of TP53-induced glycolysis and apoptosis regulator. J Pineal Res. 2017;63(4

⑩.):e12440.