卢春

发布者:张愉悦发布时间:2015-10-26浏览次数:9595



卢春 教授,理学博士,博士生导师

科学研究方向

1、病毒与肿瘤

2、分子病毒学

联系方式

通讯:江苏省南京市江宁区龙眠大道101号学海楼B507211166

电话:025-86869399

电邮:clu@njmu.edu.cn



欢迎访问卢春教授实验室网站!



简介

卢春,南京医科大学特聘教授。教育部新世纪优秀人才支持计划入选者,霍英东青年教师基金获得者,江苏省“333工程”第二层次培养对象,江苏省高校“青蓝工程”中青年学术带头人,第九届江苏省优秀青年科技奖获得者。目前任江苏省微生物学会理事长、SCI收录期刊J Med Virol杂志副主编。先后主持国家自然科学基金重点项目1项,国家自然科学基金——美国国立卫生研究院(NSFC-NIH)重点国际合作项目2项、国家自然科学基金面上项目7项,在Trends MicrobiolNucleic Acids ResPLoS PathogCell Death DifferOncogeneJ Virol等国际权威期刊上发表SCI论文30余篇。

 

教育背景及工作经历

1994-1997  南京农业大学获理学博士学位

2000-2002  美国芝加哥Loyola大学微生物学系博士后研究

1997-2000  南京医科大学讲师

2000-2005  南京医科大学副教授

2005-至今   南京医科大学教授

 

奖项及荣誉

2008年江苏省六大人才高峰五年建设优秀人才

2006年第九届江苏省青年科技奖

2006年教育部新世纪优秀人才支持计划入选者

2006年霍英东青年教师基金获得者

2003年江苏省“333工程第二层次培养对象

2003年江苏省高校青蓝工程中青年学术带头人

 

学术兼职

1. SCI收录期刊《J Med Virol》(医学病毒学)杂志副主编

2. 江苏省微生物学会理事长

3. 中华医学会医学病毒学分会常务委员

4. 中国微生物学会理事

 

承担科研课题

1. 国家自然科学基金重点项目,长链非编码RNAlncRNAs)调控KSHV诱导内皮细胞迁移侵袭与血管生成及其分子机制研究(81730062),主持人。

2. 国家自然科学基金——美国国立卫生研究院(NSFC-NIH)重点国际合作项目,KSHV microRNAs促进血管生成与肿瘤侵袭及其分子机制的研究(81761128003),主持人。

3. 国家自然科学基金——美国国立卫生研究院(NSFC-NIH)重点国际合作项目,卡波氏肉瘤病毒(KSHV)编码的microRNAs在细胞转化和肿瘤形成中的作用(81361120387),主持人。

 

近五年代表性论文、专利

1. Li W, Wang Q, Qi X, Lu H, Chen Y, Shi J, Wang F, Wang Z, Lu Z, Yan Q, Wang C*, Gao SJ, Lu C*.An oncogenic viral interferon regulatory factor upregulates CUB domain-containing protein 1 to promote angiogenesis by hijacking transcription factor lymphoid enhancer-binding factor 1 and metastasis suppressor CD82.Cell Death Differ. 2020 Jun 17. doi: 10.1038/s41418-020-0578-0.

2. Li W, Wang Q, Qi X, Guo Y, Lu H, Chen Y, Lu Z, Yan Q, Zhu X*, Jung JU, Tosato G, Gao SJ, Lu C*.Viral interleukin-6 encoded by an oncogenic virus promotes angiogenesis and cellular transformation by enhancing STAT3-mediated epigenetic silencing of caveolin 1.Oncogene, 2020Jun;39(23):4603-4618.

3. Ding X, Xu J, Wang C, Feng Q, Wang Q, Yang Y, Lu H, Wang F, Zhu K, Li W, Yan Q, Gao SJ, Lu C*. Suppression of the SAP18/HDAC1 complex by targeting TRIM56 and Nanog is essential for oncogenic viral FLICE-inhibitory protein-induced acetylation of p65/RelA, NF-κB activation, and promotion of cell invasion and angiogenesis. Cell Death Differ, 2019Oct;26(10):1970-1986.

4. Li W, Wang Q, Feng Q, Wang F, Yan Q, Gao SJ, Lu C*. Oncogenic KSHV-encoded interferon regulatory factor upregulates HMGB2 and CMPK1 expression to promote cell invasion by disrupting a complex lncRNA-OIP5-AS1/miR-218-5p network. PLoS Pathog. 2019 Jan 30;15(1):e1007578.

5. Ding X, Jia X, Wang C, Xu J, Gao SJ, Lu C*. A DHX9-lncRNA-MDM2 interaction regulates cell invasion and angiogenesis of cervical cancer. Cell Death Differ, 2019 Sep;26(9):1750-1765.

6. Yan Q, Zhao R, Shen C, Wang F, Li W, Gao SJ, Lu C*. Upregulation of miR-711 mediates HIV-1 Vpr promotion of KSHV latency and induction of pro-proliferative/survival cytokines by targeting the Notch/NF-κB signaling axis. J Virol, 2018;92(18). pii: e00580-18

7. Li W, Hu M, Wang C, Lu H, Chen F, Xu J, Shang Y, Wang F, Qin J, Yan Q, Krueger B J, Renne R, Gao SJ, Lu C*. A viral microRNA downregulates metastasis suppressor CD82 and induces cell invasion and angiogenesis by activating the c-Met signaling. Oncogene, 2017;36(38):5407-5420

8. Qin J, Li W, Gao SJ, Lu C*. KSHV microRNAs: Tricks of the devil. Trends Microbiol,2017;25(8):648-661.

9. Yan Q, Shen C, Qin J, Li W, Hu M, Lu H, Qin D, Zhu J, Gao SJ, Lu C*. HIV-1 Vpr inhibits Kaposi's sarcoma-associated herpesvirus lytic replication by inducing miR-942-5p and activating NF-κB signaling. J Virol, 2016;90(19):8739-53

10. Li W, Yan Q, Ding X, Shen C, Hu M, Zhu Y, Qin D, Lu H, Krueger BJ, Renne R, Gao SJ, Lu C*. The SH3BGR/STAT3 pathway regulates cell migrationand angiogenesis induced by a gammaherpesvirus microRNA.PLoS Pathog, 2016;12(4):e1005605.

11. Yao S, Hu M, Hao T, Li W, Xue X, Xue M, Zhu X, Zhou F, Qin D, Yan Q*, Zhu J, Gao SJ, Lu C*. MiRNA-891a-5p mediates HIV-1 Tat and KSHV Orf-K1 synergistic induction of angiogenesis by activating NF-κB signaling. Nucleic Acids Res, 2015;43(19):9362-78

12. Hu M, Wang C, Li W, Lu W, Bai Z, Qin D, Yan Q*, Zhu J, Krueger BJ, Renne R, Gao SJ, Lu C*. A KSHV microRNA directly targets G protein-coupled receptor kinase 2 to promote the migration and invasion of endothelial cells by inducing CXCR2 and activating AKT signaling. PLoS Pathog, 2015; 11(9):e1005171

13. Xue M, Yao S, Hu M, Li W, Hao T, Zhou F, Zhu X, Lu H, Qin D, Yan Q*, Zhu J, Gao SJ, Lu C*. HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway. Nucleic Acids Res, 2014; 42(15):9862-9879

14. Zhu X, Guo Y, Yao S, Yan Q, Xue M, Hao T, Zhou F, Zhu J, Qin D*, Lu C*. Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway. Oncogene, 2014; 33(15):1986-1996

15. Yan Q, Ma X, Shen C, Cao X, Feng N, Qin D, Zeng Y, Zhu J, Gao S, Lu C*. Inhibition of Kaposi’s sarcoma-associated herpesvirus lytic replication by HIV-1 Nef and cellular microRNA hsa-miR-1258. J Virol, 2014; 88(9):4987-5000

16. Bai Z, Huang Y, Li W, Zhu Y, Jung JU, Lu C*, Gao SJ*. Genomewide mapping and screening of Kaposi's sarcoma-associated herpesvirus (KSHV) 3'untranslated regions identify bicistronic and polycistronic viral transcripts as frequent targets of KSHV microRNAs. J Virol, 2014; 88(1):377-392