肖明

发布者:张愉悦发布时间:2016-02-25浏览次数:11014

肖 明  教授  博导 

江苏省神经退行性疾病重点实验室PI

科学技术处副处长







学术兼职:

中国药理学会神经精神药理专业委员会委员、中国微循环学会神经变性病专业委员会委员、中国医促会认知障碍分会委员。担任International Neuroscience 副主编,Int J Behav Res &PsycholInt J ClinExpNeurol 7种英文期刊编辑,30余种SCI期刊审稿专家;日本科学促进会(JSPS)项目、荷兰NIH重点项目、国家自然科学基金委重大科研仪器项目评审专家。


教育经历:

2002.92005.7,  南京医科大学药理学博士  

1997.92001.7,  南京医科大学人体解剖和组织胚胎学,硕士

1990.91995.7,  南京医科大学临床医学,本科


科研与学术工作经历:

2015.10-至今南京医科大学基础医学院药理学系、江苏省神经退行性疾病重点实验室,教授

2012.9-2015.9, 南京医科大学,基础医学院人体解剖学系,教授

2006.9-2012.8, 南京医科大学,基础医学院人体解剖学系,副教授

2002.8-2005.6, Lousivlle大学, 神经科学与解剖学系, 访问学者

2001.9-2006.8, 南京医科大学,基础医学院人体解剖学系,讲师

1995.8-2001.8, 南京医科大学,基础医学院人体解剖学系,助教


主持科研项目(课题)及人才计划项目情况:

1. 国家自然科学基金面上项目,82071199,脑膜淋巴管介导肺源性B淋巴细胞免疫应答调控5xFAD小鼠病理进程的机制研究,2021.01-2024.12,在研

2. 国家自然科学基金面上项目,81871117,星形胶质细胞-神经元线粒体跨细胞转运失稳态介导脑衰老进程中基底前 脑胆碱能退行性变的机制研究,2019.01-2022.12,在研

3. 国家自然科学基金面上项目,81671070,水通道蛋白4在胶质淋巴系统清除功能和3 xTg-AD小鼠病理进程中的作用,2017.01-2020.12,已结题(待批准)

4. 国家自然科学基金面上项目,81271210,水通道蛋白-4在阿尔茨海默病进程中的作用及机制,2013/01-2016/12,已结题

5. 国家自然科学基金面上项目,30971020,水通道蛋白-4对星形胶质细胞功能的调节及其与阿尔茨海默病的相关性研究,2010/01-2012/12,已结题

6. 江苏省普通高校“青蓝工程”学术带头人培养对象

7. 江苏省“六大人才高峰”高层次人才培养对象


代表性(共同)通讯作者论文:

1. Feng W, Zhang Y, Wang Z, Xu H, Wu T, Marshall C, Gao J*, Xiao M*. Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer's disease mouse model with suppression of glymphatic clearance.Alzheimers Res Ther. 2020;12:125. 

2. Zou W, Pu T, Feng W, Lu M, Zheng Y, Du R, Xiao M*, Hu G*. Blocking meningeal lymphatic drainage aggravates Parkinson's disease-like pathology in mice overexpressing mutated α-synuclein. TranslNeurodegener. 2019;8:7.

3. Zhang H, Wu J, Wu J, Fan Q, Zhou J, Wu J, Liu S, Zang J, Ye J, Xiao M*, Tian T*,Gao J*. Exosome-mediated targeted delivery of miR-210 for angiogenic therapy aftercerebral ischemia in mice. J Nanobiotechnology. 2019;17:29.

4. Wang L, Zhang Y, Zhao Y, Marshall C, Wu T, Xiao M*. Deep cervical lymph nodeligation aggravates AD-like pathology of APP/PS1 mice. Brain Pathol. 2019;29:176-192.

5. Mestre H#, Hablitz LM#, Xavier AL#, Feng W#, Zou W#, Pu T#, Monai H#, Murlidharan G#, Castellanos Rivera RM#, Simon MJ#, Pike MM#, Plá V#, Du T#, Kress BT#, Wang X, Plog BA,Thrane AS, Lundgaard I, Abe Y, Yasui M, Thomas JH, Xiao M*, Hirase H*, Asokan A*,Iliff JJ*, Nedergaard M*. Aquaporin-4-dependent glymphatic solute transport in the rodent brain. Elife. 2018;7. pii: e40070.

6. Wang L, Cao M, Pu T, Huang H, Marshall C, Xiao M*. Enriched Physical Environment Attenuates Spatial and Social Memory Impairments of Aged SociallyIsolated Mice. Int J Neuropsychopharmacol. 2018;21:1114-1127.

7. Chen Y, Yin M, Cao X, Hu G, Xiao M*. Pro- and Anti-inflammatory Effects ofHigh Cholesterol Diet on Aged Brain. Aging Dis. 2018;9:374-390.

8. Cao M, Hu PP, Zhang YL, Yan YX, Shields CB, Zhang YP, Hu G, Xiao M*. Enriched physical environment reverses spatial cognitive impairment of socially isolatedAPPswe/PS1dE9 transgenic mice before amyloidosis onset. CNS NeurosciTher. 2018;24:202-211.

9. Cao M, Pu T, Wang L, Marshall C, He H, Hu G, Xiao M*. Early enriched physical environment reverses impairments of the hippocampus, but not medial prefrontalcortex, of socially-isolated mice. Brain Behav Immun. 2017;64:232-243.

10. Xu ZQ, Huang H, Chen YL, Gao YY, Xu J, Marshall C, Cai ZY, Xiao M*. Different Expression Patterns of Amyloid-β Protein Precursor Secretases in Human and Mouse Hippocampal Neurons: A Potential Contribution to Species Differences in Neuronal Susceptibility to Amyloid-β Pathogenesis. J Alzheimers Dis. 2016;51:179-195.

11. Xu Z#, Xiao N#, Chen Y#, Huang H, Marshall C, Gao J, Cai Z, Wu T, Hu G, Xiao M*. Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation andmemory deficits. MolNeurodegener. 2015;10:58.

12. Huang H, Wang L, Cao M, Marshall C, Gao J, Xiao N, Hu G, Xiao M*. IsolationHousing Exacerbates Alzheimer's Disease-Like Pathophysiology in Aged APP/PS1Mice. Int J Neuropsychopharmacol. 2015;18:pyu116.

13. Wu Q, Zhang YJ, Gao JY, Li XM, Kong H, Zhang YP, Xiao M*, Shields CB, Hu G.Aquaporin-4 mitigates retrograde degeneration of rubrospinal neurons byfacilitating edema clearance and glial scar formation after spinal cord injury inmice. MolNeurobiol. 2014;49:1327-37.

14. Liu XL, Lu YS, Gao JY, Marshall C, Xiao M*, Miao DS, Karaplis A, Goltzman D,Ding J*. Calcium sensing receptor absence delays postnatal brain development viadirect and indirect mechanisms. MolNeurobiol. 2013;48(3):590-600.

15. Yang W, Wu Q, Yuan C, Gao J, Xiao M*, Gu M, Ding J, Hu G. Aquaporin-4 mediatesastrocyte response to β-amyloid. Mol Cell Neurosci. 2012;49(4):406-14.

16. Liu L, Lu Y, Kong H, Li L, Marshall C, Xiao M*, Ding J, Gao J, Hu G.Aquaporin-4 deficiency exacerbates brain oxidative damage and memory deficitsinduced by long-term ovarian hormone deprivation and D-galactose injection. Int JNeuropsychopharmacol. 2012;15(1):55-68.


学术著作:

1. 《阿尔茨海默病》科学出版社, ISBN 978-7-03-043035-9,副主编

2. 《阿尔茨海默病分子生物学》科学出版社, ISBN 978-7-03-047286-1,副主编

3. AquaporinsSpringer ISSN 0065-2598, 参编

4. 《哈里森神经内科学》,北京大学医学出版社,9787030559968,参译

 

科技获奖:

1. 阿尔茨海默病的血管—免疫异常机制研究与调控 2016年度江苏省科学技术奖,三等奖,排名第二

2. 星形胶质细胞在神经退行性疾病发病机制中的作用研究 2016年度江苏省教育科学研究成果,二等奖,排名第一