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郭兴


发布时间: 2018-04-02 访问次数: 872
     
          

郭兴,博士,博士生导师
神经生物学系教授

研究方向:
(1)线粒体功能紊乱与神经退行性疾病之间的关联
(2)线粒体质量控制的分子机制

联系方式:guox@njmu.edu.cn


      
       

        

个人简介:

郭兴博士,男,1983年出生,籍贯山西省太原市,教授,博士生导师。博士研究生毕业于北京协和医学院遗传学专业。主要研究方向为线粒体质量控制与神经退行性疾病。目前主持国家自然科学基金面上项目1项,蛋白质组学国家重点实验室开放课题1项。在SCI收录期刊杂志上发表文章7篇,代表性论文发表在JCINature Communications等专业高水平杂志上。


近年承担课题情况

国家自然科学基金面上项目(项目批准号:31472326),剪接因子SFRS5的泛素化和乙酰化修饰调控研究,2015.01-2018.1280万元,主持。

代表性论文:

1. Guo X, Sun XY, Hu D, Zhang RL, Wang YJ, Fujioka H, Luo Y, and Qi X, VCP recruitment to mitochondria by mutant Huntingtin causes mitophagy impairment and neurodegeneration in models of Huntington's disease, Nat Commun, 2016 Aug 26;7:12646. PMID: 27561680

2. Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D and Qi X, Inhibition of mitochondrial fragmentation diminishes Huntington’s disease-associated neurodegeneration. J Clin Invest, 2013 Dec 2; 123(12): 5371-88. PMID: 24231356.  

3. Guo X and Qi X, VCP cooperates with UBXD1 to degrade mitochondrial outer membrane protein MCL1 under the conditions associated with Huntington's disease. BBA-Molecular Basis of Disease, 2017 Feb; 1863(2):552-559. PMID: 27913212

4. Guo X, Sesaki H and Qi X, Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo. Biochem J, 2014 Jul 1; 461(1):137-46. PMID: 24758576. (Highlighted by Biochem J via podcast, 2014 Jul)

5. Su YC, Guo X and Qi X, Threonine56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy. BBA-Molecular Basis of Disease, 2015 Jan, 1852(1): 12-21(Co-first author) PMID: 25446991

6. Guo X, Shen S, Song SS, He S, Cui Y, Xing GC, Wang J, Fan LB, He FC, Zhang LQ. The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum. J. Biol. Chem. 2011, 286(20): 18037-18047. PMID: 21454619

7. Luo X, Wu J, Li Y, Nan Z, Guo X, Wang Y, Zhang A, Wang Z, Xia G, Tian Y. Synergistic Effects of GhSOD1 and GhCAT1 Overexpression in Cotton Chloroplasts on Enhancing Tolerance to Methyl Viologen and Salt Stresses. Plos one. 2013 Jan 15; 8(1): 1-11. PMID: 23335985


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