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陈允梓                                 免疫学


发布时间: 2015-10-27 访问次数: 2346

陈允梓,博士,教授,博士生导师

研究方向:营养与免疫性疾病

地址:南京市汉中路140号免疫学系

邮编:210029

电话:025-86869453


  陈允梓,男,博士,教授,2005年于南京大学获得生物化学与分子生物学博士学位。2006-2012在美国芝加哥大学从事博士后工作,主要研究围绕营养物质维生素D在炎症性疾病和自身免疫性疾病中的作用及其分子机制。曾在J. Clin. Invest.J. Immunol.J. Bio. Chem.Inflamm. Bowel Dis.等国际著名期刊上发表SCI科研论文20多篇,主持过一项芝加哥大学医学院基金,参与多项美国国立卫生研究院(NIH)基金项目。目前,承担一项国家自然科学基金面上项目(在研)。

研究基金和课题:

1. Targeting microRNA by vitamin D for regulating inflammatory disease.2010, CTSA-ITM (The University of Chicago Institute for Translational Medicine Core Subsidies funding Grant number UL1 RR024999)

2.《维生素D及其受体(Vitamin D/VDR)在内毒素耐受中的作用及机制研究》国家自然科学基金(81371759),70万,2014-2018(主持)

代表性成果:

1.   Du J, Chen Y*, Shi Y, Liu T, Cao Y, Tang Y, Ge X, Nie H, Zheng C, Li YC. 1,25-Dihydroxyvitamin D Protects Intestinal Epithelial Barrier by Regulating the Myosin Light Chain Kinase Signaling Pathway. Inflamm Bowel Dis. 2015 Aug 17.*Co-corresponding author
  2.   Li YC, Chen Y, Du J.  Critical roles of intestinal epithelial vitamin D receptor signaling in controlling gut mucosal inflammation. J Steroid Biochem Mol Biol. 2015 Apr;148:179-83
  3.   Chen Y*, Du J, Zhang Z, Liu T, Shi Y, Ge X, Li YC. MicroRNA-346 Mediates Tumor Necrosis Factor α-Induced Downregulation of Gut Epithelial Vitamin D Receptor in Inflammatory Bowel Diseases. Inflamm Bowel Dis. 2014 Nov;20(11):1910-8 *Co-corresponding author
  4.   Li YC, Chen Y, Liu W, Thadhani R. MicroRNA-mediated mechanism of vitamin D regulation of innate immune response. J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:81-6
  5.   Liu W*, Chen Y*, Golan M.A., Annunziata M.L., Du J, Dougherty U., Kong J, Musch M., Huang Y, Pekow J., Zheng C, Bissonnette M., Hanauer S.B., Li YC Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis. J Clin. Invest. 2013, 123(9):3983-3996.
  * Co-first authors equally contributed to the work
  6.  Chen Y, Liu W, Sun T, Huang Y, Wang Y, Deb D.K., Yoon D, Kong J, Thadhani R., Li YC 1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages. J Immunol. 2013, 190(7):3687-3695.
  7.  Chen Y, Zhang J, Ge X, Du J, Deb D.K., Li YC Vitamin D receptor inhibits nuclear factor κB activation by interacting with IκB kinase β protein. J Biol. Chem. 2013, 288(27):19450-19458.
  8.  Kong J, Chen Y, Zhu G, Zhao Q, Li YC. 1,25-Dihydroxyvitamin D3 upregulates leptin  expression in mouse adipose tissue. J Endocrinol. 2013, 216(2):265-271.
  9.  Wang Y, Deb D.K., Zhang Z, Sun T, Liu W, Yoon D., Kong J, Chen Y, Chang A, Li YC Vitamin D receptor signaling in podocytes protects against diabetic nephropathy. J Am. Soc. Nephrol. 2012, 23(12):1977-1986.
  10.  Deb D.K., Wang Y, Zhang Z, Nie H., Huang X, Yuan Z, Chen Y, Zhao Q, Li YC Molecular mechanism underlying 1,25-dihydroxyvitamin D regulation of nephrin gene expression. J Biol. Chem. 2011, 286(37):32011-32017.
  11.  Chen Y, Kong J, Sun T, Li G, Szeto F.L., Liu W, Deb D.K., Wang Y, Zhao Q, Thadhani R., Li YC 1,25-Dihydroxyvitamin D₃ suppresses inflammation-induced expression of plasminogen activator inhibitor-1 by blocking nuclear factor-κB activation. Arch. Biochem. Biophys. 2011, 507(2):241-247.
  12.  Zhang J, Chen Y, Huang Q, Cheng W, Kang Y, Shu L, Yin W, Hua ZC Nuclear localization of c-FLIP-L and its regulation of AP-1 activity. Int. J Biochem. Cell Biol. 2009, 41(8-9):1678-1684.
  13.  Zhang Y, Deb D.K., Kong J, Ning G, Wang Y, Li G, Chen Y, Zhang Z, Strugnell S., Sabbagh Y., Arbeeny C., Li YC Long term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist. Am. J Physiol. Renal. Physiol. 2009, 297(3):F791-801.
  14.  Deb D.K., Chen Y, Zhang Z, Zhang Y, Szeto F.L., Wong K.E., Kong J, Li YC. 1,25-Dihydroxyvitamin D3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-{kappa}B pathway. Am. J Physiol. Renal. Physiol. 2009 , 296(5):F1212-1218.

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