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孙秀兰 药理学


发布时间: 2015-10-27 访问次数: 1319

孙秀兰博士,教授,博士生导师

          药理学系主任

研究方向:神经精神类疾病的病理损伤机制和神经保护新靶标

地址:南京市汉中路140号药理学系

邮编:210029

电话:025-86869405

E-mail:xiulans@njmu.edu.cn


       孙秀兰,女,1973年10月出生。教授,博士生导师。江苏省“六大人才高峰(A)类”和“333工程”高层次培养对象,南京医科大学学科带头人培养对象。《中国应用生理学杂志》、《中国医药导报》编委,Neuropharmacology、Brain Research、CEPP等多个国际学术期刊审稿人。

近5年发表论文(*通讯作者): 
  1. Ji J, Yan H, Chen ZZ, Zhao Z, Yang DD, Sun XL*, Shi YP. Iptakalim protects against ischemic injury by improving neurovascular unit function in the mouse brain. Clin Exp Pharmacol Physiol. 2015;42(7):766-71
  2. Wei Liu, Jun Gu, Jun Qi, Xiao-Ning Zeng, Juan Ji, Zheng-Zhen Chen, Xiu-Lan Sun*. Lentinan exerts synergistic apoptotic effects with paclitaxel in A549 cells via activating ROS-TXNIP-NLRP3 inflammasome. J Cell Mol Med. 2015;19(8):1949-55
  3. Xia MX, Ding X, Qi J, Gu J, Hu G, Sun XL*. Inhaled budesonide protects against chronic asthma-induced neuroinflammation in mouse brain. J Neuroimmunol. 2014;273(1-2):53-7
  4. Lu M, Sun XL, Qiao C, Liu Y, Ding JH, Hu G. Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation. Neurobiol Aging. 2014; 35(2):421-30 (Co-first author)
  5. Zhao AP, Dong YF, Liu W, Gu J, Sun XL*. Nicorandil inhibits inflammasome activation and Toll-like receptor signal transduction to protect against oxygen -glucose deprivation induced inflammation in BV-2 cells. CNS Neurosci Ther. 2014;20(2):147-53
  6. Wang L, Zhai YQ, Xu LL, Qiao C, Sun XL, Ding JH, Lu M, Hu G. Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice. Exp Neurol. 2013; 251C:22-29
  7. Dong YF, Wang LX, Huang X, Cao WJ, Lu M, Ding JH, Sun XL, Hu G. Kir6.1 knockdown aggravates cerebral ischemia/reperfusion-induced neural injury in mice. CNS Neurosci Ther. 2013; 19(8):617-24
  8. Guo RB, Sun PL, Zhao AP, Gu J, Ding X, Qi J, Sun XL*, Hu G.  Chronic asthma results in cognitive dysfunction in immature mice.  Exp Neurol. 2013; 247:209-17
  9. Shi JQ, Zhang CC, Sun XL, Cheng XX, Wang JB, Zhang YD, Xu J, Zou HQ. Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-κB and NLRP3 inflammasome activation. CNS Neurosci Ther. 2013; 19(4):262-8
  10. Guo RB, Wang GF, Zhao AP, Gu J, Sun XL*, Hu G. Paeoniflorin protects against ischemia-induced brain damages in rats via inhibiting MAPKs/NF-κB-mediated inflammatory responses. PLoS One. 2012; 7(11): e49701. doi: 10.1371/journal.pone.0049701
  11. Yu Gong, Xiu-Lan Sun, Fang-Fang Wu, Chun-Jin Su, Jian-Hua Ding, Gang Hu. Female Early Adult Depression Results in Detrimental Impacts on the Behavioral Performance and Brain Development in Offspring. CNS Neuroscience & Therapeutics. 2012;18 (6): 461–470 (co-first author)
  12. Sun XL,  Liu Y,  Dai T, Ding JH, Hu G. Uncoupling  protein  2  knockout  exacerbates  depression-like  behaviors  in  mice  via  enhancing  inflammatory response. Neuroscience 2011;192: 507–514
  13. Gong Y, Chai Y, Ding JH, Sun XL*, Hu G. Chronic Mild Stress Damages Mitochondrial Ultrastructure and Function in Mouse Brain. Neurosci Lett. 2011;488(1):76-80
  14. Sun XL, Hu G. ATP-sensitive potassium channels: A promising target for protecting neurovascular unit function in stroke. Clin Exp Pharmacol Physiol. 2010;37(2):243-52 
科研获奖:
1. 中国药理学会青年药理学工作者奖(2013年)
  2. 中国药理学会青年药理学工作者奖(2008年)
  3. 北京市科技进步一等奖(2006年)
  4. 军队科技进步一等奖(2005年)
  5. 南京市科技进步三等奖(2003年,2004年)
获得专利:
  1. 4-芳香氨基喹唑啉衍生物及制备方法和在制药中的应用 ZL200710025643.1
  2. 管状闭合器 ZL201220545921.2
目前在研项目:
  1. 国家自然科学基金项目(81473197)过氧化物酶体增殖物激活受体在抑郁症中的关键作用,2015.1-2018.12,80万元
  2. 国家自然科学基金项目(81273495)ATP敏感性钾通道开放剂对缺血性脑卒中后神经血管单元功能的调节及其作用机制,2013.1-2016.12,80万元;
  3. 江苏省高校自然科学重大基础研究项目(12KJA310002),ATP敏感性钾通道开放剂对缺血性脑卒中后神经血管单元功能的调节及其作用机制,2012.9-2015.12,30万元
 

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