孙崇秀 生物化学与分子生物学

发布者:郭继承发布时间:2015-03-24浏览次数:2705

 

孙崇秀,博士

 
 
 
 

研究方向:内皮功能失调与动脉粥样硬化

 
   
 

地址:南京市汉中路140号生物化学与分子生物学系

 
 邮编:210029 
 

E-mail:cxsun@njmu.edu.cn

 
 

 

 

 

    孙崇秀,女,博士,南京医科大学生化学系教授。研究领域集中于严重影响人类健康的心血管疾病的分子病理机制。2006年于南京大学生物化学与分子生物学专业获得博士学位,学位论文基于蛋白质结构与功能的研究,探求动脉粥样硬化斑块脱落导致血栓形成这一临床病理过程的有效拮抗剂。为专业期刊如ArteriosclerThrombVascBiol、Mol Cell Biochem审稿人。2015年1月受聘于南京医科大学,将着眼于动脉粥样硬化的始动环节-内皮细胞功能失调,综合运用前沿的分子生物学方法,细胞生物学技术和实验动物模型,探索心血管疾病风险因素的作用机制,为寻找有效的干预靶点提供实验支持。

代表性论著:
  •Wang YI, Bettaieb A, Sun C, Radecke CE, Mathew S, Edwards CM, Passerini AG, Haj FG, Simon SI. Triglyceride-rich lipoprotein modulates inflammatory VCAM-1 expression via differential regulation of endoplasmic reticulum stress and IRF-1 expression. (PloSOne. 2013 Oct 21;8(10). PMID: 24205197
  •Deverse JS, Sandhu AS, Mendoza N, Edwards CM, Sun C, Simon SI, Passerini AG. Shear stress modulates VCAM-1 expression in response to TNFα and dietary lipids via interferon regulatory factor-1 in cultured endothelium. Am J Physiol Heart Circ Physiol. 2013 Aug 9. PMID: 23934855
  •Sun C, Rigor RR, Konia T, Wu MH and Yuan SY. ADAM15 deficiency attenuates pulmonary hyperpermeability and acute lung injury in lipopolysaccharide-treated mice. Am J PhysiolLung Cell Mol Physiol. 2013 Feb 1;304(3):L135-42. PMID: 23161886
  •Sun C, Wu MH, Lee ES, and Yuan S. ADAM15 contributes to atherosclerosis by mediating endothelial barrier dysfunction via Src family kinase activity. ArteriosclerThrombVasc Biol. 2012 Oct;32(10):2444-51. PMID: 22904271
  •Sun C, Alkhoury K, Wang Y, Foster GA, Radecke CE, Tam K, Edwards CM, Facciotti MT, Armstrong EJ, Knowlton AA, Newman JW, Passerini AG, Simon SI. IRF-1 and miRNA126 Modulate VCAM-1 Expression in Response to a High Fat Meal.Circ Res. 2012 Sep 28;111(8):1054-64. PMID: 22874466
  •Guo M, Yuan SY, Frederich BJ, Sun C, Shen Q, McLean DL, Wu MH. Role of Non-Muscle Myosin Light Chain Kinase in Neutrophil-Mediated Intestinal Barrier Dysfunction During Thermal Injury.Shock. 2012 Jul 18. PMID: 22814287
  •Lee ES, Shen Q, Pitts RL, Guo M, Wu MH, Sun SC, Yuan SY. Serum metalloproteinases MMP-2, MMP-9, and metalloproteinase tissue inhibitors in patients are associated with arteriovenous fistula maturation. J Vasc Surg. 2011 Aug;54(2):454-9. PMID: 2162062
  •Sun C, Wu MH, Yuan SY. nmMLCK deficiency ameliorates atherosclerosis in ApoE-deficient mice via reduced endothelial barrier dysfunction and monocyte migration. Circulation. 2011 Jul 5;124(1):48-57. PMID: 21670231
  •Schulte S, Sun J, Libby P, Macfarlane L, Sun C, Lopez-Ilasaca M, Shi GP, Sukhova GK. Cystatin C Deficiency Promotes Inflammation in Angiotensin II-Induced Abdominal Aortic Aneurisms in Atherosclerotic Mice. Am J Pathol.2010 Jul;177(1):456-63. PMID: 20472891
  •Sun C, Wu MH, Guo M, Day ML, Lee ES, Yuan SY. ADAM15 regulates endothelial permeability and neutrophil migration via Src/ERK1/2. Cardiovasc Res.2010 Jul 15;87(2):348-55. PMID: 20189953.
  •Sun C, Chen P, Lu W, Liu JN. Tyr178 of beta3 is critical for alphaIIb maturation and macromolecular ligand binding to alphaIIbbeta3.Throm Res.2008;122(2):203-10.
  •Sun J, Sukhova GK, Yang M, Wolters PJ, MacFarlane LA, Libby P, Sun C, Zhang Y, Liu J, Ennis TL, Knispel R, Xiong W, Thompson RW, Baxter BT, Shi GP. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest.2007;117(11):3359-68.
  •Kitamoto S, Sukhova GK, Sun J, Yang M, Libby P, Love V, Duramad P, Sun C, Zhang Y, Peters C, Shi G-P. Cathepsin L Deficiency Reduces Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Knockout Mice. Circulation. 2007;115:2065-75.
  •Chen P *, Sun C*, and Liu JN. A Novel Anti-platelet mAb Specific for the Complex of Integrin alphaIIbbeta3 Inhibits Platelet Aggregation and Adhesion. J Biol Chem. 2005, 280: 25403-25408. (*Equal contribution)