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曹新


发布时间: 2014-04-08 访问次数: 2429

 

  

  曹新,博士,教授,博士生导师。生物技术系主任。
  研究方向:遗传病分子发病机制的研究

  地址:南京市江宁区龙眠大道101号  生物技术系

  邮编:211166

  电话:025-86869341

  Email: caoxin@njmu.edu.cn


    曹新,博士,教授,博士生导师。生物技术系主任。20017月毕业于上海交通大学医学院、上海医学遗传研究所遗传学专业,获博士学位。同年进入南京医学大学基础医学院任教。2006-2007年在美国宾夕法尼亚大学(University of Pennsylvania)医学院访问学习。

主要从事分子遗传学研究,重点研究人类遗传性疾病分子病因学及其临床应用,利用现代分子生物学和遗传学技术寻找新的致病基因并揭示其发病机制;通过从临床遗传学到基础分子生物学的研究,为遗传病的基因诊断、分子干预和遗传咨询提供理论基础和临床指导。近五年来在国内外专业学术期刊上共发表研究论文30多篇,SCI收录期刊论文20余篇;获国家发明专利1项、申请国家发明专利2项;先后主持国家自然科学基金面上项目2项、江苏省重点研发计划(社会发展)项目1项、江苏省自然科学基金项目2项和其他类项目5项。兼任江苏省生物化学与分子生物学学会常务理事,江苏省细胞与发育生物学学会理事。

  

发表论文(*通讯作者)

1.Chunyu Liu, Jun Yao, Qinjun Wei, Guangqian Xing*, Xin Cao*. Spatial and temporal expression patterns of Osbpl2a and Osbpl2b during zebrafish embryonic development. International Journal of Pediatric Otorhinolaryngology, 2016, 84:174-9.

2.Shuya Zhang, Jiehua Ma, Ziyi Fu, Zhilei Zhang, Jian Cao, Lei Huang, Wenqu Li, Pengfei Xu*, Xin Cao*. Promotion of breast cancer cells MDA-MB-231 invasion by di (2-ethylhexyl) phthalate through matrix metalloproteinase-2/-9 overexpression. Environ Sci Pollut Res, 2016, 23(10):9742-9.

3.Guangqian Xing, Jun Yao, Bin Wu, Tingting Liu, Qinjun Wei, Cheng Liu, Yajie Lu, Zhibin Chen, Heng Zheng, Xiaonan Yang, Xin Cao*. Identification of OSBPL2 as a novel causative gene of progressive nonsyndromic hearing loss by exome sequencing. Genetics in Medicine, 2015, 17(3):210-8.

4.Li-Yang MN, Shen XF, Wei QJ, Yao J, Lu YJ, Cao X, Xing GQ*. IVS8+1 DelG, a Novel Splice Site Mutation Causing DFNA5 Deafness in a Chinese Family. Chin Med J (Engl)., 2015;128(18):2510-5.

5.Yao J, Qian X, Bao J, Wei Q, Lu Y, Zheng H, Xing G*, Cao X*. Probing the effect of two heterozygous mutations in codon 723 of SLC26A4 on deafness phenotype based on molecular dynamics simulations. Sci Rep., 2015, 5: 10831.

6.Qian XL, Qin LY, Xing G, Cao X*. Phenotype Prediction of Pathogenic Nonsynonymous Single Nucleotide Polymorphisms in WFS1. Sci Rep., 2015, 5:14731.

7.Lu YJ, Yao J, Wei Q, Xing G*, Cao X*. Diagnostic Value of SLC26A4 Mutation Status in Hereditary Hearing Loss With EVA: A PRISMA-Compliant Meta-Analysis. Medicine, 2015, 94(50): e2248.

8.Tan M, Shen X, Yao J, Wei Q, Lu Y, Cao X*, Xing G*. Identification of I411K, a novel missense EYA4 mutation causing autosomal dominant non‑syndromic hearing loss.Int J Mol Med., 2014, 34(6):1467-72.

9.Wei Q, Zhu H, Qian X, Chen Z, Yao J, Lu Y, Cao X*, Xing G*.Targeted genomic capture and massively parallel sequencing to identify novel variants causing Chinese hereditary hearing loss.J Transl Med., 2014, 12(1):311.

10.Lu Y, Yao J, Yu J, Wei Q, Cao X*. The association between abnormal microRNA -10b expression and cancer risk: a meta-analysis.Sci Rep.,2014, 4:7498.

11.Han XH, Fan Y, Wei QJ, Xing GQ, Cao X*. Understanding of the molecular evolution of deafness-associated pathogenic mutations of connexin 26.Genetica, 2014, 142(6):555-62.

12.Qinjun Wei, Youguo Liu, Shuai Wang, Tingting Liu, Yajie Lu, Guangqian Xing* and Xin Cao*. A novel compound heterozygous mutation in the GJB2 gene causing non-syndromic hearing loss in a family. International Journal of Molecular Medicine, 2014, 33: 310-316.

13.Qinjun Wei, Shuai Wang, Jun Yao, Yajie Lu, Zhibin Chen, Guangqian Xing*, Xin Cao*. Genetic mutations of GJB2 and mitochondrial 12S rRNA in nonsyndromic hearing loss in Jiangsu Province of China. J Translational Medicine, 2013, 11:163.

14.Jie Chen, Qinjun Wei, Jun Yao, Xiaoyun Qian, Yanhong Dai, Ye Yang, Xin Cao*, Xia Gao*. Identifi cation of two heterozygous deafness mutations in SLC26A4 (PDS) in a Chinese family with two siblings. International J Audiology, 2013, 52(2): 134-138.

15.Qinjun Wei, Dan Xu, Zhibin Chen, Haifeng Li, Yajie Lu, Cheng Liu, Xingkuan Bu, Guangqian Xing*, Xin Cao*. Maternally transmitted aminoglycoside-induced and non-syndromic hearing loss caused by the 1494C>T mutation in the mitochondrial 12S rRNA gene in two Chinese families. International J Audiology, 2013, 52(2): 98-103.

16.Wei Q, He W, Yao J, Guo L, Lu Y, Cao X. Identification and characterization of microRNAs expressed in human breast cancer T-47D cells in response to prolactin treatment by Solexa deep-sequencing technology.Biochem Biophys Res Commun., 2013,432(3):480-7.

17.Jun Yao, Yajie Lu, Qinjun Wei, Xin Cao* and Guangqian Xing*. A systematic review and meta-analysis of 235delC mutation of GJB2 gene. Journal of Translational Medicine,2012,10:136

18.Cheng H, Chen Z, Wei Q, Lu Y, Xing G*, Cao X*. Single nucleotide polymorphisms and haplotypes analysis of DFNB1 locus in Chinese sporadic hearing impairment population. Chin Med J., 2009, 122(13): 1549-53.

19.Dai D, Lu Y, Chen Z, Wei Q, Cao X*, Xing G*. Co-segregation of the T1095C with the A1555G mutation of the mitochondrial 12S rRNA gene in a patient with non-syndromic hearing loss. Biochem Biophyl Res Commun, 2008, 377(4): 1152-1155.

 

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