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陈玲


发布时间: 2014-03-17 访问次数: 1017
 

陈玲,博士,教授,博士生导师

 
   日本名古屋大学医学部兼职讲师 
  研究方向:甾体激素对神经元损伤和再生的基础和应用基础研究  
 
 
 
 

地址:南京市汉中路140号生理学系

 
 

邮编:210029

 
 

电话:86-25-86862878  传真:86-25-86260332

 
 

E-mail: lingchen@njmu.edu.cn

 

个人简历:
1982年毕业于江苏大学医学院临床专业。
1982-1989年在江苏大学附属医院任内科医生
1990年留学于日本筑波大学医学部神经生物学研究室,1995年获医学博士学位。
1996-1998年在日本生命科学研究所读博士后。
1999-2005年在日本名古屋大学医学部进行日本科技厅国际共同研究,作为子课题负责人主持(13480216)“神经甾体激素与阿尔茨海默病的研究”的相关研究。
2006年回国,目前重点进行“神经甾体激素与与阿尔茨海墨病、肌萎缩侧索硬化等神经退行性疾病”等相关性的研究。
所属学会
中国神经科学学会、中国生理学会、海内外华人神经科学学会、日本生理学会、日本神经科学学会、日本药理学学会、美国神经科学学会、美国Cerebral Blood Flow & Metabolism学会。
研究经费状况:
已结题:
1. 江苏省卫生厅重点研究项目,“α7-N型乙酰胆碱受体激动剂对Aβ损害大鼠记忆的保护作用”,(编号:H200205)2006-2008年。
2. 日本科技厅国际合作项目,“硫化孕稀醇酮异构调控α7nAChR,拮抗Aβ神经毒作用的研究”,(编号:L07565),2006-2007年。
目前主持:
1. 国家自然科学基金,“硫化孕稀醇酮改善Aβ大鼠认知障碍的分子机制”,(编号:30872725),2009-2011年。
2. 教育部博士点基金,“硫化孕稀醇酮阻止和改善Aβ诱导认知障碍的分子机制研究”,(编号:200803120006),2009-2011年。
作为PI主持课题
1. 长江学者和创新团队发展计划资助,“生殖健康基础与临床研究”,(编号:IRT0631),2006-2010年。
承担雌激素与阿尔茨海默病发病的分子机制研究)。
2. 国家“973”计划,“环境和遗传因素导致男性不育与生后缺陷的分子机制”,(编号:2009CB941701),2009-2013年。
承担环境雌激素扰乱下丘脑-腺垂体-靶腺内分泌轴的分子机制研究)。

近五年发表的主要论著目录(CA:通讯作者
1. Zhang Z, Yang R, Zhou R, Li L, Sokabe M, Chen LCA. Progesterone promotes the survival of newborn neurons in the dentate gyrus of adult male mice. Hippocampus 20:402-12 (2010). (IF=5.28)
2. Chen LCA, Cai W, Chen Lei, Zhou R, Sokabe M. Modulatory metaplasticity induced by pregnenolone sulfate in the rat hippocampus: A leftward shift in LTP/LTD-frequency curve. Hippocampus 20:499-512 (2010). (IF=5.28)
3. Zhang Z, Yang R, Bei Y, Sokabe M, Chen LCA. Treatment with progesterone after focal cerebral ischemia suppresses proliferation of progenitor cells but enhances survival of newborn neurons in adult male mice. Neuropharmacology58:930-939 (2010). (IF=3.78)
4. Chen L, Wang H, Zhang Z, Li Z, He D, Sokabe M, Chen LCA. DMXB (GTS-21) ameliorates the cognitive deficits in beta amyloid(25-35(-)) injected mice through preventing the dysfunction of alpha7 nicotinic receptor. J. Neurosci. Res. 10:124-129 (2010). (IF=3.24)
5. Li L, Xu BZ, Chen L, Sokabe M, Chen LCA. DHEA prevents Aβ25-35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling. Neuropharmacology59:944-951 (2010). (IF=3.78)
6. Chi S, Cai W, Liu P, Zhang Z, Chen X, Gao L, Chen LCA, Qi Z. Baifuzi reduces transient ischemic brain damage through an interaction with the STREX domain of BKCa channels. Cell Death and Disease 1:13-22 (2010). (IF=?? )
7. Li Z, Cui S, Zhang Z, Zhou R, Ge Y, Sokabe M, Chen LCA. DHEA-neuroprotection and -neurotoxicity after transient cerebral ischemia in rats. Journal of Cerebral Blood Flow & Metabolism 154: 482-495 (2009). (IF=5.74)
8. Zhou R, Zhang Z, Zhu Y, Chen L, Sokabe M, Chen LCA. Deficits in development of synaptic plasticity in rat dorsal striatum following prenatal and neonatal exposure to low-dose bisphenol-A. Neuroscience159:161-171 (2009). (IF=3.44)
9. Li WL, Cai HH, Wang B, Chen L, Zhou QG, Luo CX, Liu N, Ding XS, Zhu DY. Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke.J Neurosci Res. 87:112-122 (2009). (IF=3.41)
10. Yu Y, Wu J, Fan Y, ?Zhuo Lv, Guo X, Zhao C, Zhou R, Zhang Z, Wang F, Xiao M, Chen L, Zhu H, Chen W, Lin M, Liu J, Zhou Z, Wang L, Huo R, Zhou Q, Sha J. Evaluation of blastomere biopsy using mouse model indicates the potential high-risk of neurodegenerative disorders in the offspring. Molecular & Cellular proteomics (in-press). (IF=9.81)
11. Cai W, Zhu Y, Furuya K, Li Z, Sokabe M, Chen LCA. Two different molecular mechan isms underlying progesterone neuroprotection against ischemic brain damage. Neuropharmacology 55:127-138 (2008). (IF=3.78)
12. Hu M, Sun YJ, Zhou QG, Chen L, Hu Y, Luo CX, Wu JY, Xu JS, Li LX, Zhu DY. Negative regulation of neurogenesis and spatial memory by NR2B-containing NMDA receptors. J Neurochem. 106:1900-1913 (2008).(IF=4.26)
13. Chen LCA, Miyamoto Y, Mori N, Sokabe M. Signaling mechanisms of long-lasting potentiation induced by neurosteroid PREGS in rat hippocampus: requirement of ERK1/2 activation. J Neurophysiology 98:1538-1548 (2007). (IF=3.85)
14. Dai X, Chen L, Sokabe M. Estrogen enhances behavioral recovery and decreases neuronal loss after traumatic brain injury. Neuropharmacology 52:1124-1138 (2007). (IF=3.78)
15. Sokabe M, Chen L. Effects of pregnenolone sulfate on the cognitive dysfunction in the beta amyloid25-35–infused mice. Jap. Neuropharmacology 10:2-6 (2007). (IF=1.76)
16. Chen L, Yamada K, Nabeshima T, Sokabe M. α7 nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP in β-amyloid infused rats. Neuropharmacology 50:254-268 (2006). (IF=3.78)
17. Chen LCA, Miyamoto Y, Mori N, Sokabe M. PREGS induces LTP in the hippocampal dentate gyrus of adult rats via the tyrosine phosphorylation of NR2B coupled to ERK/CREB signaling. J Neurophysiology 98:1538-1548 (2006). (IF=3.85)
18. Chen L, Dai X, Sokabe M. Chronic administration of DHEAS primes for facilitation induction of long-term potentiation via sigma 1 receptor: optical imaging study in rat hippocampal slices. Neuropharmacology 50:380-392 (2006). (IF=3.78)
19. Chen LCA, Miyamoto Y, Mori N, Sokabe M. Chronic DHEAS administration facilitates hippocampal long-term potentiation via an amplification of Src-dependent NMDA receptor signaling. Neuropharmacology 51:659-670 (2006). (IF=3.78)
20. Li Z, Zhou R, Cui SZ, Xie GQ, Sokabe M, Chen LCA. Neurosteroid DHEAS exerts protective effects against ischemic deficit in hippocampal LTP via tyrosine phosphorylation of NMDA receptor. Neuropharmacology 51:958-966 (2006). (IF=3.78)
21. Chen L, Sokabe M. Presynaptic modulation of synaptic transmission by pregnenolone sulfate as studied by optical recordings. J Neurophysiology 94: 4131-4144 (2005). (IF=3.853)
22. Miyamoto Y, Chen L, Sato M, Sokabe M, Nabeshima T, Sakai R, Mori N. Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor. J Neurosci. 25:1826-1835 (2005). (IF=8.6)
23. Xu Y, Tanaka Y, Chen L, Sokabe M. DHEAS induces short-term potentiation via the activation of a metabotropic glutamate receptor in the rat hippocampus. Hippocampus (IF=5.78). (in-press).
24. Zhu Y, Zhou R, Zhang Z, Xu BZ, Goltzman D, Miao D, Chen LCA. Abnormal neurogenesis in the dentate gyrusof adult mice lacking 1,25(OH)2D3. Hippocampus (IF=5.78). (revised).
25. Yang R, Zhou R, Chen L, Cai WY, Sokabe M, Chen LCA. Pregnenolone sulfate promotes survival of adult-generated hippocampal granule cells via sustained presynaptic potentiation.Hippocampus (IF=5.78). (revised).

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