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杨俭


发布时间: 2014-03-17 访问次数: 2541

杨俭,博士,教授,博士生导师

   
研究方向:神经药理学和临床药理学
  

地址:南京市汉中路140号药理学系

邮编:210029

电话:025-86869408


  杨俭,女,1961年12月出生,博士。南京医科大学药理系教授、博士生导师、系副主任。江苏省“六大人才高峰” B类培养对象。2004.7~2008.6美国罗得岛大学药学院作访问学者,从事药物代谢酶的转录(核受体)调节,药物、草药、激素之间的相互作用的研究。期间申请并获得主持美国NIH postdoctoral 基金1项。

研究兴趣和方向:神经药理学和临床药理学。

目前主持课题

  1. 美国NIH International postdoctoral fellowship grant, “Transcription Activation-Based Herb-Drug Interactions (PA03-050 - 1 F05 AT003019-01 )  (2005-2010)”

  2. 国家自然科学基金“在对IL6的反应中DEC1负性调节肝脏药物代谢酶CYP3A4表达(30772616)(2008-2010)”

近期发表论文

  1. Jian Yang, Deshi Shi, Dongfang Yang, Xiulong Song, and Bingfang Yan. Interleukin-6 Alters the Cellular Responsiveness to Clopidogrel, Irinotecan, and Oseltamivir by Suppressing the Expression of Carboxylesterases HCE1 and HCE2.Mol Pharmacol 2007, 72(3):684-694

  2. Yang J, Yan B. Photochemotherapeutic agent 8-methoxypsoralen induces Cytochrome P450 3A4 and Carboxylesterase HCE2: Evidence on an Involvement of the Pregnane X Receptor. Toxicol Sci.2007;95(1):13-22

  3. Jian Yang, Jack Champitelli, Gang Hu, Yanhe Lin, Jin Luo, Chun Xue. Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin. Life Sci. 2007, 81:272-279.

  4. Yang J, Hu LF, Liu X, Zhou F, Ding JH, Hu G. Effects of iptakalim on the extracellular glutamate and dopamine levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats: a microdialysis study. Life Sci.2006, 78(17):1940-4.

  5. Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, Yan B. The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter. Oncogene. 2006 Jun 1;25(23):3296-306.

  6. Shi D, Yang J, Yang D, Lucluyse EL, Black C, You L,Akhlaghi F, Yan B . Anti-Influenza viral prodrug oseltamivir is activated by carboxylesterase and the activation is inhibited by ?anti-platelet agent clopidogrel. J Pharmacol Exp Ther. 2006;319(3):1477-84.

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