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梁秀彬


发布时间: 2014-03-17 访问次数: 1395

梁秀彬,博士,教授,博士生导师

    
研究方向:肾小球硬化的分子机制
      

地址:南京市汉中路140号代谢疾病研究中心

邮编:210029

电话:025-86869356


  梁秀彬,女,医学博士,南京医科大学特聘教授,博士生导师。1994年毕业于山西医科大学,获医学学士学位。2003年毕业于北京大学第一医院肾脏内科学专业,获医学博士学位。同年开始在美国Vanderbilt University病理系进行博士后研究,主要研究方向是肾小球硬化的分子机制。2005年继续在美国University of Pittsburgh细胞生物学系进行博士后研究,主要研究方向为肾脏远端肾单位上皮细胞钠离子通道的分子调控。并于2008年被University of Pittsburgh细胞生物学系聘为助理教授。2009年12月回国,受聘于南京医科大学继续从事肾脏疾病的发病机制的研究。曾作为项目负责人完成美国心脏协会和美国Cystic Fibrosis Fundation资助项目。2005年获得美国病理协会颁发的Young Investigator奖。

主要研究方向

主要研究课题之一是肾脏集合管钠离子通道调控机制的研究
                          代表论著
                          1. Liang X, Butterworth MB, Peters KW, Walker WH, Frizzell RA. An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel. J Biol Chem. 2008;283:27418-27425
                          2. Zhang Y, Zhang H, Hou P, Liang X, Li Z, Wang H. The novel gene AngRem104 downregulatesglucocorticoid receptor expression and activates NF-kappaB in human mesangial cells. Biochem Biophys Res Commun. 2008;369:1057-1060
                          3.Liang X, Peters KW, Butterworth MB, Frizzell RA. 14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channels. J Biol Chem. 2006;281:16323-16332
                          4. Liang XB, Ma LJ, Naito T, Wang Y, Madaio M, Zent R, Pozzi A, Fogo AB. Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J Am Soc Nephrol. 2006;17:1886-1895
                          5. Liang X, Kanjanabuch T, Mao SL, Hao CM, Tang YW, Declerck PJ, Hasty AH, Wasserman DH, Fogo AB, Ma LJ. Plasminogen activator inhibitor-1 modulates adipocyte differentiation. Am J Physiol Endocrinol Metab. 2006;290:E103-E113
                          6. Ma LJ, Nakamura S, Aldigier JC, Rossini M, Yang H, Liang X, Nakamura I, Marcantoni C, Fogo AB. Regression of glomerulosclerosis with high-dose angiotensin inhibition is linked to decreased plasminogen activator inhibitor-1. J Am Soc Nephrol. 2005;16:966-976
                          7. Xu BJ, Shyr Y, Liang X, Ma LJ, Donnert EM, Roberts JD, Zhang X, Kon V, Brown NJ, Caprioli RM, Fogo AB. Proteomic patterns and prediction of glomerulosclerosis and its mechanisms. J Am Soc Nephrol. 2005;16:2967-2975
                          8. Liang X, Zhang H, Zhou A, Wang H. AngRem104, an angiotensin II-induced novel upregulated gene in human mesangial cells, is potentially involved in the regulation of fibronectin expression. J Am Soc Nephrol. 2003;14:1443-1451
                          9. Liang XB, Zhang H, Zhou AY, Wang HY. Screening for functional genes related to a novel gene, AngRem104, in human mesangial cells by cDNA microarray. Biotechnol Lett. 2003;25:139-142
                          10. Liang X, Zhang H, Zhou A, Hou P, Wang H. Screening and identification of the up-regulated genes in human mesangial cells exposed to angiotensin II. Hypertens Res. 2003;26:225-235

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