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季勇


发布时间: 2015-03-23 访问次数: 4032

季勇,博士,国家“百千万”人才

国家“有突出贡献中青年专家”,教授,博士生导师

研究方向: 心血管疾病的分子机制及药物防治

研究地址:南京市龙眠大道101号南京医科大学

邮编:211166

E-mail: yongji@njmu.edu.cn



      

季勇,男,19688月出生,教授,博士生导师,国家“百千万”人才,国家“有突出贡献中青年专家”,江苏省六大人才高峰及省“333高层次人才培养工程培养对象。1991年南京医学院临床医学专业本科毕业,1998年南京医科大学心血管药理学专业博士毕业;2000-2002 年获法国科技部资助,在法国国家医学科学院 (INSERM U464),马塞地中海大学医学院做事博士后研究,主要研究蛋白质的相互关系。2002-2004年获得了Wellcome Trust 基金的资助,在英国伦敦大学国王学院工作。现为南京医科大学副校长兼药学院院长江苏省心脑血管重点实验室主任。

研究方向与特色:

1) 活性气体信号分子NOH2S及其所介导的蛋白质巯基亚硝基化修饰及硫化修饰在心血管疾病中的作用及其调控机制。

2)心室重构、动脉粥样硬化、高血压、糖尿病、缺血再灌注损伤等心血管疾病的病理生理分子机制及药物的防治。


学术成就和兼职:先后主持了科技部973前期研究专项1项、国家自然科学基金重点项目1、国家自然科学基金重大研究计划重点项目1项、国家自然科学基金面上项目4项、省级基金项目6项、作为课题骨干参与1“973”项目。近年来在Circ ResNat CommunDiabetesAntioxid Redox Signal等国际专业学术期刊上发表SCI论文70,累计影响因子300多,获教育部高等学校科学研究优秀成果奖(自然科学奖)一等奖1项、江苏省科学技术奖一等奖1项、中华医学科学技术二等奖1项及国家授权发明专利1项。现担任英国药理学报British Journal of Pharmacology)副主编,中国病理生理学会动脉粥样硬化专业委员会副主任委员,中国生物化学与分子生物学会脂质与脂蛋白专业委员会委员兼青年委员会副主任委员,中国病理生理学会心血管专业委员会委员,国际动脉粥样硬化学会中国分会理事中国药理学会心血管药理专业委员会常委,江苏省药理学会副理事长


近年来发表的代表性论著:

1. Liu W*, Ruiz-Velasco A, Wang S, Khan S, Zi M, Jungmann A, Dolores Camacho-Muñoz M, Guo J, Du G, Xie L, Oceandy D, Nicolaou A, Galli G, Müller OJ, Cartwright EJ, Ji Y*, Wang X*. Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling. Nat Commun. 2017;8(1):494.(通讯作者)

2. Xi H, Zhang Y, Xu Y, Yang WY, Jiang X, Sha X, Cheng X, Wang J, Qin X, Yu J, Ji Y*,Yang X*, Wang H*.Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial Cells.Circ Res. 2016;118(10):1525-1539. (通讯作者)

3. Yang J, Fang P, Yu D, Zhang L, Zhang D, Jiang X, Yang WY, Bottiglieri T, Kunapuli SP, Yu J, Choi ET, Ji Y*, Yang X*, Wang H*. Chronic Kidney Disease Induces Inflammatory CD40+ Monocyte Differentiation via Homocysteine Elevation and DNA Hypomethylation. Circ Res. 2016;119(11):1226-1241.(通讯作者)

4. Xie L, Gu Y, Wen M, Zhao S, Wang W, Ma Y, Meng G, Han Y, Wang Y, Liu G, Moore PK, Wang X, Wang H, Zhang Z, Yu Y, Ferro A, Huang Z*, Ji Y*.Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation.Diabetes. 2016;65(10):3171-3184. (通讯作者)

5. Wang J, Wang W, Li S, Han Y, Zhang P, Meng G, Xiao Y, Xie L, Wang X, Sha J, Chen Q, Moore PK, Wang R, Xiang W*, Ji Y*. Hydrogen sulfide as a potential target in preventing spermatogenic failure and testicular dysfunction. Antioxid Redox Signal. 2017 May 24. doi: 10.1089/ars.2016.6968.(通讯作者)

6. Meng G, Liu J, Liu S, Song Q, Liu L, Xie L, Han Y*, Ji Y*. Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3 dependent manner.Br J Pharmacol. 2017 May 15. doi: 10.1111/bph.13861.(通讯作者)

7. Xie L, Feng H, Li S, Meng G, Liu S, Tang X, Ma Y, Han Y, Xiao Y, Gu Y, Shao Y, Park CM, Xian M, Huang Y, Ferro A, Wang R, Moore PK, Wang H*, Ji Y*.SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells.Antioxid Redox Signal. 2016;24(6):329-343.(通讯作者)

8. Chao ML, Guo J, Cheng WL, Zhu XY, She ZG, Huang Z, Ji Y*, Li H*.Loss of Caspase-Activated DNase Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice.J Am Heart Assoc. 2016;5(12). pii: e004362.(通讯作者)

9. Tang Y, Li S, Zhang P, Zhu J, Meng G, Xie L, Yu Y, Ji Y*, Han Y*.Soy Isoflavone Protects Myocardial Ischemia/Reperfusion Injury through Increasing Endothelial Nitric Oxide Synthase and Decreasing Oxidative Stress in Ovariectomized Rats.Oxid Med Cell Longev.2016;2016:5057405.(通讯作者)

10. Meng G, Xiao Y, Ma Y, Tang X, Xie L, Liu J, Gu Y, Yu Y, Park CM, Xian M, Wang X, Ferro A, Wang R, Moore PK, Zhang Z, Wang H, Han Y*, Ji Y*.Hydrogen Sulfide Regulates Krüppel-Like Factor 5 Transcription Activity via Specificity Protein 1 S-Sulfhydration at Cys664 to Prevent Myocardial Hypertrophy.J Am Heart Assoc. 2016;5(9). pii: e004160.(通讯作者)

11. Cheng WL, Wang PX, Wang T, Zhang Y, Du C, Li H*,Ji Y*. Regulator of G-protein signalling 5 protects against atherosclerosis in apolipoprotein E-deficient mice. BrJ Pharmacol. 2015;172(23):5676-5689.(通讯作者)

12. Meng G, Zhu J, Xiao Y, Huang Z, Zhang Y, Tang X, Xie L, Chen Y, Shao Y, Ferro A, Wang R, Moore PK,Ji Y*. Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis.Oxid Med Cell Longev. 2015;2015:691070.(通讯作者)

13. Meng G, Ma Y, Xie L, Ferro A,Ji Y*. Emerging role of hydrogen sulfide in hypertension and related cardiovascular diseases. Br J Pharmacol.2015,172(23):5501-5511.(通讯作者)

14. Zhang W, Han Y, Meng G, Bai W, Xie L, Lu H, Shao Y, Wei L, Pan S, Zhou S, Chen Q, Ferro A,Ji Y*. Direct renin inhibition with aliskiren protects against myocardial ischemia/reperfusion injury by activating nitric oxide synthase signaling in spontaneously hypertensive rats. J Am Heart Assoc. 2014; 3(1):e000606.(通讯作者)

15. Shan LY, Li JZ, Zu LY, Niu CG, Ferro A, Zhang YD, Zheng LM*,Ji Y*. Platelet-derived microparticles are implicated in remote ischemia conditioning in a rat model of cerebral infarction.CNS Neurosci Ther. 2013;19(12):917-925.(通讯作者)

16. Liu Z, Han Y, Li L, Lu H, Meng G, Li X, Shirhan M, Peh MT, Xie L, Zhou S, Wang X, Chen Q, Dai W, Tan CH, Pan S, Moore PK,Ji Y*. The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E(-/-) mice. Br J Pharmacol.2013;169(8):1795-1809. (通讯作者)

17. Xie L, Liu Z, Lu H, Zhang W, Mi Q, Li X, Tang Y, Chen Q, Ferro A, Ji Y*.Pyridoxine inhibits endothelial NOS uncoupling induced by oxidized low-density lipoprotein via the PKCα signalling pathway in human umbilical vein endothelial cells. Br J Pharmacol. 2012;165(3):754-764.(通讯作者)

18. Yu SS, Cai Y, Ye JT, Pi RB, Chen SR, Liu PQ*, Shen XY*, Ji Y*. Sirtuin 6 protects cardiomyocytes from hypertrophy in vitrovia inhibition of NF-κB-dependent transcriptional activity. Br J Pharmacol.2013 ;168(1):117-128. (通讯作者)

19. Mi Q, Chen N, Shaifta Y, Xie L, Lu H, Liu Z, Chen Q, Hamid C, Becker S, Ji Y*, Ferro A*. Activation of endothelial nitric oxide synthase is dependent on its interaction with globular actin in human umbilical vein endothelial cells.J Mol Cell Cardiol. 2011;51(3):419-427.(通讯作者)

20. O'Kane P,Xie L, Liu Z, Queen L, Jackson G, Ji Y*, Ferro A*. Aspirin acetylates nitric oxide synthase type 3 in platelets thereby increasing its activity. Cardiovasc Res. 2009;83(1):123-130.(通讯作者)

21. Ji Y, Ferracci G, Warley A, Ward M, Leung KY, Samsuddin S, Le´veˆque C, Queen L, Reebye V, Pal P, Gkaliaqkousi E, Seager M, Ferro A*. beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90. Proc Natl AcadSci U S A. 2007; 104(21):8839-8844.


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