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苏川 病原生物学


发布时间: 2015-10-26 访问次数: 2654

     


苏川,博士,教授,博士生导师
江苏省现代病原生物学重点实验室主任
基础医学院副院长


研究方向:病原生物学与免疫学

地址:南京市汉中路140号病原生物学系

邮编:210029

电话:025-86869326


1)苏川的简历:

苏川,男,1970年7月生,1993年本科毕业于南京医科大学临床医学系并获医学学士学位, 1998年研究生毕业于南京医科大学病原生物学专业并获医学博士学位。2001年1月至2003年12月在美国Rochester大学进行博士后研究工作。现在为南京医科大学基础医学院副院长,江苏省重点学科(国家重点学科培育建设点)---病原生物学系教授、博士研究生导师,江苏省现代病原生物学重点实验室主任。是中华预防医学会医学寄生虫分会第五届常务委员、第四届江苏省热带病与寄生虫学分会主任委员、江苏省动物学会寄生虫学专业分会主任委员、江苏省动物学会理事、江苏省微生物与免疫学会理事。入选江苏省“青兰工程”优秀青年学术带头人、江苏省“333工程”和“六大人高峰”人才培养计划。


主要从事感染免疫应答调控的相关研究工作。主持了国家自然科学基金重点项目1项、国家“863计划重大专项1项、国家“973”课题1项(骨干)、科技部重大科技专项(传染病重大专项)子课题1项、国家自然科学基金面上项目等6项、江苏省自然科学基金重大项目1项、江苏省教育厅重大基础研究项目2项等多个国家及省部级重要科研项目。共发表论文130多篇,其中国外SCI论文29篇。近年的研究成果共获得省部级奖4项,授权和申报国家发明专利共4项。共同主编人民卫生出版社五年制临床医学国家规划教材《人体寄生虫学》第八版、副主编人民卫生出版社长学制临床医学国家规划教材《人体寄生虫学》第三版。

  

1988.091993.07  南京医科大学(原称南京医学院)临床医学系,本科/学士

1993.09-1998.07  南京医科大学病原生物学系,(1995年硕转博连读)研究生/博士

1998.082000.12     南京医科大学病原生物学系,讲师

2001.012003.12     美国University of RochesterMedical Center博士后

2004.012007.07  南京医科大学病原生物学系副主任,副教授,博士研究生导师

            江苏省现代病原生物学重点实验室副主任

2007.09-现在   南京医科大学病原生物学系教授

2008.04-现在    江苏省现代病原生物学重点实验室主任

2009.022012.06      南京医科大学病原生物学系主任

2012.062017.01     南京医科大学基础医学院副院长

2017.02-现在    南京医科大学人事处长

  

2)苏川发表的SCI论文:

1. Lei He#, Sha Zhou#, Qianqian Qi, Ying Chi, Jifeng Zhu, Zhipeng Xu, Xuefeng Wang, Jason Hoellwarth, Feng Liu, Xiaojun Chen*, and Chuan Su*.  The regulation of regulation: IL-10 increases CD4+CD25+regulatory T cells but impairs their immunosuppressive activity in murine models with schistosomiasis japonica or asthma. Immunology.2017.doi: 10.1111/imm.12813. [Epub ahead of print]  (IF 3.701)

2. XianchengDong, Bin Lv, YusongLi, QinghuaCheng, Chuan Su*, GuoyongYin*. MiR-143 regulates the proliferation and migration of osteosarcoma cells through targeting MAPK7.  Archives of Biochemistry and Biophysics. 2017, 630:47-53. doi: 10.1016/j.abb. 2017.07.011.  [Epub ahead of print]  (IF 3.165)

3. Xiaojun Chen,Wei Li,Yalin Li,Lei Xu,Sha Zhou,Jifeng Zhu,Zhipeng Xu*,Feng Liu,Dandan Lin,Fei Hu,Yuemin Liu,Wen Jiang,Liwang Cui,Chuan Su*. Elevated serum antibody against Schistosoma japonicum HSP60 as a promising biomarker for liver pathology in schistosomiasis. Scientific Reports. 2017, 7(1):7765. doi: 10.1038/s41598-017-08283-5. (IF 4.259)

4. Zhipeng Xu, Lei Xu , Wei Li, Xin Jin, Xian Song, Xiaojun Chen*, Jifeng Zhu, Sha Zhou, Yong Li,Weiwei Zhang, Xiaoxiao Dong, Xiaowei Yang, Feng Liu, Hui Bai, Qi Chen, and Chuan Su*. Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection.  Nature Communications 2017,8:16035. doi: 10.1038/ ncomms16035.  (IF 12.124)

5. Ying Chi+, Yiyue Ge+, Kangchen Zhao, Bingjie Zou, Bin Liu, Xian Qi, Qian Bian, Zhiyang Shi, Fengcai Zhu, Minghao Zhou, Lunbiao Cui*, Chuan Su*Multiplex Reverse- Transcription Loop-Mediated Isothermal Amplification Coupled with Cascade Invasive Reaction and Nanoparticle Hybridization for Subtyping of Influenza A Virus. Scientific Reports. 2017,21;7:44924. doi: 10.1038/srep44924IF 4.259

6. Xiaoyun YuJingang An, Yunhui Hua, Zihai LiNing YanWeixin Fan*, Chuan Su* MicroRNA-194 regulates keratinocyte proliferation and differentiation by targeting Grainyhead-like 2 in psoriasis. Pathology Research and Practice 2017 Feb;213(2):89-97 IF 1.543

7. Jing Sun†, Run Shi†, Sha Zhao, Xiaona Li, Shan Lu, Hemei Bu, Xianghua Ma*, Chuan Su*E2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycle.  Journal of Experimental & Clinical Cancer Research 2017,7;36(1):40. doi: 10.1186/s13046-017-0504-6. IF 5.189

8. Sha Zhou, Xin Jin, Yalin Li, Wei Li, Xiaojun Chen, Lei Xu, Jifeng Zhu, Zhipeng Xu, Yang Zhang, Feng Liu, Chuan Su*Blockade of PD-1 signaling enhances Th2 cell responses and aggravates liver immunopathology in mice with Schistosomiasis japonica. PLoS NTD 2016 DOI:10.1371/journal.pntd.0005094 IF 3.834

9. Xiaowei Wang, Xiaojun Chen, Heng Tang, Jifeng Zhu, Sha Zhou, Zhipeng Xu, Feng Liu, and Chuan Su*.  Increased Frequency of Th17 Cells in Children with Mycoplasma pneumoniae Pneumonia.  Journal of Clinical Laboratory Analysis 2016, 00: 1–6. doi: 10.1002/jcla.22005. IF 1.521

10. Jie Yang, Pu Li, Chuan Su, Jia-Yi Zhang, and Min Gu.  Worms Expelled With the Urine From a Bosniak Cyst III of the Left Kidney.  Urology. 2016 Jul;93:e5. doi: 10.1016/j.urology.2016.02.024.

11. Sha Zhou, Xin Jin, Xiaojun Chen, Jifeng Zhu, Zhipeng Xu, Xuefeng Wang, Feng Liu, Wei Hu, Liang Zhou, Chuan Su*Heat Shock Protein 60 in Eggs Specifically Induces Tregs and Reduces Liver Immunopathology in Mice with Schistosomiasis japonica.  PLoS ONE 2015; 10(9): e0139133. doi: 10.1371/journal.pone.0139133 (IF 3.234)

12. Xiaojun Chen, Wei Li, Yang Zhang, Xian Song, Lei Xu, Zhipeng Xu, Sha Zhou, Jifeng Zhu, Xin Jin, Feng Liu, Gengxin Chen, Chuan Su*  Distribution of Peripheral Memory T Follicular Helper Cells in Patients with Schistosomiasis Japonica.  PLoS NTD 2015, 9(8):e0004015. doi: 10.1371/journal.pntd.0004015  (IF 4.446)

13. Weiwei Zhang, Jifeng Zhu, Xian Song, Zhipeng Xu, Xue Xue, Xiaojun Chen, Xiaowei Yang, Yong Li, Xiaoxiao Dong, Sha Zhou, Wei Li, Yingying Qian, Feng Liu, Chuan Su* An association of Aquaporin-4 with the immunoregulation of liver pathology in mice infected with Schistosoma japonicum. Parasites and Vectors 2015, 8(1): 37  DOI: 10.1186/s13071-015-0650-7  *Corresponding author(IF 3.430)

14. Sha Zhou, Xiaoxiao Dong, Cui Zhang, Xiaojun Chen, Jifeng Zhu, Wei Li, Xian Song, Zhipeng Xu, Weiwei Zhang, Xiaowei Yang, Yong Li, Feng Liu, Chuan Su*.  MicroRNAs are implicated in the suppression of CD4+CD25- conventionalT cell proliferation by CD4+CD25+ regulatory T cells.  Molecular Immunology 2015, 63: 464-472  *Corresponding author(IF 2.973)

15. Xiaojun Chen, Xiaowei Yang, Yong Li, Jifeng Zhu, Sha Zhou,Zhipeng Xu, Lei He, Xue Xue,Weiwei Zhang, Xiaoxiao Dong, Henry Wu, Carrie J Li, Hsiang-Ting Hsu, Wenjun Kong, Feng Liu, Prem B. Tripathi, Michelle S. Yu, Jason Chang, Liang Zhou, Chuan Su*.  Follicular Helper T Cells Promote Liver Pathology in Miceduring Schistosoma japonicum Infection.  PLoS Pathogens 2014, 10(5): e1004097. doi:10.1371/ journal. ppat.1004097  *Corresponding author(IF 7.562)  

16. Jifeng Zhu, Zhipeng Xu, Xiaojun Chen, Sha Zhou, Weiwei Zhang, Ying Chi, Wei Li, Xian Song, Feng Liu, Chuan Su*.   Parasitic antigens alter macrophage polarization during Schistosoma japonicum infection in mice.  Parasites and Vectors 2014,7:122 DOI: 10.1186/1756-3305-7-122  *Corresponding author(IF 3.250)

17. Yang Dai, Xiaoting Wang, Song Zhao, Jianxia Tang, Lu Zhang, Yinchang Zhu, Jianrong Dai, Mingtao Zeng, Shan Lu, Chuan Su*.Construction and evaluation of replication- defective recombinant optimized triosephosphateisomerase adenoviral vaccination in Schistosoma japonicum challenged mice.  Vaccine 2014, 32(7): 771-778 *Corresponding author(IF 3.492)

18. Xuefeng Wang, Liyang Dong, Hongchang Ni, Sha Zhou, Zhipeng Xu, Jason Shih Hoellwarth, Xiaojun Chen, Rongbo Zhang, Qiaoyun Chen, Feng Liu, Jun Wang, Chuan Su. Combined TLR7/8 and TLR9 Ligands Potentiate the Activity of a Schistosoma japonicum DNA Vaccine.  PLoS NTD 2013 7(4): e2164. doi:10.1371/journal.pntd. 0002164   (IF 4. 569)

19. Xuefeng Wang, Fan Liu, Sha Zhou, Zhipeng Xu, Jason Hoellwarth, Xiaojun Chen, Lei He, Rongbo Zhang, Feng Liu, Jun Wang, Chuan Su.  Partial Regulatory T Cell Depletion Prior to Schistosomiasis Vaccination Does Not Enhance the Protection.  PLoS ONE 2012, 7(7): e40359. doi:10.1371/journal.pone.0040359   (IF 3. 73)

20. Xiaoyun Wen, Lei He, Ying Chi, Sha Zhou, Jason Hoellwarth, Cui Zhang, Jifeng Zhu, Calvin Wu, Shawn Dhesi, Xuefeng Wang, Feng Liu,Chuan Su*. Dynamics of Th17 Cells and Their Role in Schistosoma japonicum Infection in C57BL/6 Mice.  PLoS Negl Trop Dis 2011, 5(11): e1399. doi:10.1371/journal.pntd.0001399   *Corresponding author(IF 4.716)

21. Ying Chi, Yi Fan, Lei He, Wei Liu, Xiaoyun Wen, Sha Zhou, Xuefeng Wang, Cui Zhang, Hui Kong, Laura Sonoda, Prem Tripathi, Carrie J. Li, Michelle S. Yu,Chuan Su*, and Gang Hu.Novel role of Aquaporin-4 in CD4+CD25+ T regulatory cell development and severity of Parkinson’s disease.  Aging cell 2011,10(3): 368–382 *Corresponding author(IF 6.265)

22. Xuefeng Wang, Lei Zhang, Ying Chi, Jason Hoellwarth, Sha Zhou, Xiaoyun Wen, Lei He, Feng Liu, Calvin Wu, and Chuan Su*.  The nature and combination of subunits used in epitope-based Schistosoma japonicum vaccine formulations affect their efficacy.  Parasites & Vectors 2010, 3:109, 12 pages  *Corresponding author(IF 2. 05)

23. Xinyu Xu, Xiaoyun Wen, Ying Chi, Lei He, Sha Zhou, Xuefeng Wang, Jiaqing Zhao, Feng Liu and Chuan Su*.   Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection.  Journal of Biomedicine and Biotechnology 2010, Article ID 202397,12 pages (doi:10.1155/2010/202397)    *Corresponding author (IF 1.750)

24. Xuefeng Wang, Sha Zhou, Jason Hoellwarth, Ying Chi, Xiaoyun Wen, Lei He, Feng Liu, Calvin Wu, Shawn Dhesi, Jiaqing Zhao, Wei Hu, Chuan Su*CD4+CD25+ T regulatory cell induction by a HSP60-derived peptide SJMHE1 from Schistosoma japonicum is TLR2-dependent.    Eur. J. Immunol. 2009,39(11)3052–3062*Corresponding author (IF 5.179)

25. Tao Fangfang, Yang Yanfeng, Wang Hui, Sun Xingjuan, Luo Jie, Zhu Xiang, Liu FengWang Yong, Su Chuan, Wu Haiwei, Zhang Zhaosong.  Th1-type epitopes-based cocktail PDDV attenuates hepatic fibrosis in C57BL/6 mice with chronic Schistosoma japonicum infection.    Vaccine 2009,2427(31):4110-7  (IF 3.616)

26. Lei Zhang, Yanfen Yang, Xue Yang, Jiaqing Zhao, Jianghua Yang, Feng Liu, Zhaosong Zhang, Guanling Wu, Chuan Su*  T cell epitope-based peptide-DNA dual vaccine induces protective immunity against Schistosoma japonicum infection in C57BL/6J mice.  Microbes Infect 2008,10: 251-259     *Corresponding author (IF 2.801)

27. Michael DeRan, Mary Pulvino, Eriko Greene, Chuan Su, and Jiyong Zhao.   Transcriptional Activation of Histone Genes Requires NPAT-Dependent Recruitment of TRRAP-Tip60 Complex to Histone Promoters during the G1/S Phase Transition.    Mol. Cell. Biol. 2008, 28(1): 435–447  (IF 5.942)

28. Lei Zhang, Xue Yang, Yanfen Yang, Jiaqing Zhao, Jianghua Yang, Feng Liu, Zhaosong Zhang, Guanling Wu, Chuan Su*    Characterization of a partially protective B cell epitope within the 62kDa antigen of Schistosoma japonicum. ABBS2007,39:770–778  *Corresponding author (IF 1.017)

29. Jianghua Yang, Jiaqing Zhao, Yanfeng Yang, Lei Zhang, Xue Yang, Xiang Zhu, Minjun Ji, Nanxiong Sun, Chuan Su*Schistosoma japonicum egg antigens stimulate CD4+CD25+ T cells and modulate airway inflammation in a murine model of asthma.  Immunology 2007, 1208–18   *Corresponding author (IF 3.398)

30. Minjun Ji, Chuan Su, Yong Wang, Haiwei Wu, Xiaoping Cai, Guangfu Li, Xiang Zhu Xinjun Wang, Zhaosong Zhang, and Guanling Wu.  Characterization of CD4+ T Cell Responses in Mice Infected with Schistosoma japonicum  ABBS 2006, 38(5): 327–334  *Corresponding author (

31. Cai XP, Zhang H, Zhang YC, Wang Y, Su C, Ji MJ, Wu HW, Zhu X, Zhang ZS, Wu GL.Dynamics of CD4+CD25+ T cells in spleens and mesenteric lymph nodes of mice infected with Schistosoma japonicum.ABBS. 2006;38::299-304. (

32. Zhu X, Zhang ZS, Ji MJ, Wu HW, Wang Y, Cai XP, Zhang L, Hu SY, Fu LL, Liu F, Su C, Wu GL.   Gene transcription profile in mice vaccinated with ultraviolet- attenuated cercariae of Schistosoma japonicum reveals molecules contributing to elevated IFN-gamma levels       ABBS,2005;37(4):254-264(

33. Su Chuan, Gao Guang, Schneider S, Helt C, Weiss Casten, O'Reilly MA, Bohmann Dirk, Zhao Jiyong.  DNA damage induces downregulation of histone gene expression through the G(1) checkpoint pathway.  EMBO J. 2004,23(5):1133- 1143 (IF 10.456)

34. Minjun Ji, Chuan Su*, Haiwei Wu, Xiang Zhu, Xiaoping Cai, Chunling Li, Guangfu Li, Yong Wang, Zhaosong Zhang, and Guanling Wu*.Expression profiling of T helper cells of schistosomiasis reveals a direct involvement of interferon signaling in infective progression.  Cell Immunol 2003;224(1):55-62  *Corresponding author (IF 1.829)

35. Lei Shen, Zhaosong Zhang, Haiwei Wu, Rosemary R Weir, Zhangwu Xie, Lingshen Hu, Shuzhen Chen, Minjun Ji, Chuan Su, Yaobi Zhang, Quintin D Bickle, Sandy N Cousens, Martin G Taylor, Guanling Wu.   IFN-g is associated with risk of Schistosoma japonicum infection in China.  Parasite Immunology, 2003;25:483-487. (IF 1.956)

36. Lei Shen, Zhaosong Zhang, Haiwei Wu, Rosemary R Weir, Shuzhen Chen, Minjun Ji, Chuan Su, Yaobi Zhang, Quintin D Bickle, Sandy N Cousens, Martin G Taylor, Guanling Wu.  Down-regulation of specific antigen-driven cytokines production in a population with endemic schistosoma japonicum infection.  Clin & Exp Immunol 2002;129(2):339  (IF=2.305)

37. Zhaosong Zhang, Haiwei Wu, Shuzhen Chen, Linshen Hu, Zhangwu Xie, Yingxi Qiu, Chuan Su, Jianping Cao, Yiqing Wu, Shaoji Zhang, Guanling Wu.   Association between IgE antibody against soluble egg antigen and resistance to reinfection with Schistosoma japonicum.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE 1997, 91(5):606-608 (IF 2.553)

  

3)苏川获省级以上的重要科技奖励

“日本血吸虫病疫苗的免疫学与生物学基础研究”获国家教育部2010年度高等学校科学研究优秀成果奖(自然科学奖)二等奖 2010年 1/11

“日本血吸虫cDNA文库的构建及功能性抗原基因的克隆和鉴定  1999江苏省科学技术进步奖二等奖江苏省政府    6/8

“日本血吸虫病人群同种型抗体应答的特征及其流行病学意义”  1999国家卫生部三等奖国家卫生部    8/11

“日本血吸虫线粒体相关蛋白的特性及抗原表位的分析”  2002山东省高等学校优秀科研成果奖二等奖山东省教育厅  4/5

  

4)苏川获授权及申报的国家发明专利

授权或申报

时间

专 利 名 称

专利申请号或

授权号

国别

本人排名

2009.10.28

授权

基于T细胞表位的抗血吸虫感染的肽-DNA双疫苗

ZL200610166313.X

中国

苏川、张兆松、吴观陵

2011.07.06

授权

一种诱导CD4+CD25+调节性T细胞的多肽及应用

ZL200810234928.O

中国

苏川、汪雪峰、周莎、贺蕾、刘丰

2012.02.25

授权

一种增加CD4+CD25+ Foxp3+调节性T细胞的抗原及其应用

ZL201010133142.7

中国

苏川、周莎、汪雪峰、贺蕾、刘丰

2014.08.13

授权

SjHSP60在制备监测血吸虫病患者综合肝脏病理损伤程度的诊断试剂中的应用

ZL201210556695.2

中国

苏川、陈晓军、周莎

  

  

5) 苏川主持的主要项目

起止时间

项目名称

项目

主持人

项目来源

经费

(万元)

15.01-19.12

血吸虫感染宿主诱导Tfh细胞来促进肝脏免疫病理损害的机制研究

主持人

国家自然科学基金重点项目(81430052

320.0

15.06-15.12

中巴(NSFC-CNPq)双边学术研讨会

主持人

国家自然科学基金81581220391

3.5

13.01-16.12

血吸虫抗原诱导调节性T细胞调控宿主肝脏免疫病理损害的机制研究

主持人

国家自然科学基金81271861

105.0

13.01-15.12

血吸虫病肝脏免疫病理损害相关抗原的筛选及机制研究

主持人

江苏省教育厅重大基础研究项目(12KJA310001)

15.0

11.01-13.12

CD4+CD25+调节性T细胞对靶细胞免疫抑制作用的分子机制研究

主持人

国家自然科学基金81071385

32.0

10.01-12.12

日本血吸虫免疫病理相关抗原的筛选及免疫机制探讨

主持人

国家教育部博士点专项基金(20093234110004

6.0

11.05-11.12

已经结题

海峡两岸交流项目

主持人

国家自然科学基金(81181260115)

3.0

09.01-11.12已经结题

基于阻断免疫负调控理论的血吸虫病新概念疫苗的预研

主持人

国家自然科学基金30872206

33.0

07.07-11.12已经结题

血吸虫感染的免疫应答及调控机制

主持人

“973”子课题 (2007CB513106)

130.0

08.07-10.12

已经结题

重要寄生虫标识性抗原及其抗体的筛选和鉴定

主持人

国家科技重大专项子课题 (2008ZX10004-011)

88.56

07.01-09.12

已经结题

青年科技创新人才项目(学术带头人)

主持人

江苏省科技厅 (BK2007533)

20.0

06.01-08.12

已经结题

CD4+CD25+T细胞参与慢性日本血吸虫感染宿主免疫应答下调的研究

主持人

国家自然科学基金30571629

27.0

06.07-08.12

已经结题

血吸虫抗原表位对CD4+CD25+ Treg细胞的诱导及机制的探索性研究

主持人

江苏省教育厅重大基础研究项目(07KJA31023)

30.0

05.01

国家教育部留学回国人员科研启动基金

主持人

国家教育部

3.0

04.07-05.12

已经结题

抗日本血吸虫感染CTL-Th1-B组合表位PDDV疫苗的研制

主持人

国家“863计划重大项目(2004AA2Z3500)

150.0

02.01-04.12

已经结题

血吸虫感染致宿主免疫下调作用机理的探讨

主持人

国家自然科学基金30100156

18.0

01.01-04.12

已经结题

丙型肝炎慢性过程中Th1/Th2特性的研究

主持人

南京医科大学科技创新基金(CX200006

8.0

00.01-02.12

已经结题

日本血吸虫特异性IgE相关抗原的研究

主持人

江苏省自然科学基金(Bk99132)

4.5 


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