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戴一凡


发布时间: 2014-03-17 访问次数: 2729

戴一凡,博士,校特聘教授,博士生导师

    江苏省异种器官移植重点实验室主任
    南京医科大学代谢疾病研究中心副主任 
研究方向:异种移植、转基因大动物、omega-3脂肪酸的作用机制

地址:南京市汉中路140号代谢疾病研究中心

邮编:210029

电话:025-86869356


  戴一凡,男,中组部国家千人计划特聘教授,教育部长江学者讲座教授,卫生部抗体技术重点实验室主任,南京医科大学代谢疾病研究中心副主任,南京医科大学特聘教授,博士生导师。1983年毕业于浙江医科大学医学系,获医学学士学位;1986年毕业于浙江医科大学病理生理系,获医学硕士学位;1989年毕业于复旦大学遗传所分子遗传学专业,获博士学位。1989-1991年复旦大学遗传所,讲师;1991-1995年美国加州Salk 研究所,博士后;1995-1998年美国Baxter Healthcare 研究员;1998-2004年Revivicor Inc.资深研究员,分子生物学实验室主任;2004-2008年美国匹兹堡大学医学院外科系Starzl 器官移植研究所副教授。研究成果分别发表在Science及Nature系列杂志,先后两次进入美国<DISCOVER>杂志全球前100 重大科学发现(2002年,第36位;2006 年,第38位)。2002 年获得了Fujisawa年轻科学家奖。

主要研究方向:
                          1. 建立转基因或基因敲除的克隆猪作为异种移植的供体。
                          2. 建立新型的转基因大动物作为人类代谢疾病的大动物模型以及培育农业新品种。
                          3.  omega-3脂肪酸在抑制多种人类疾病如动脉粥样硬化、肥胖症、糖尿病和骨质疏松症和癌症上的作用。
承担科研项目情况
                          1.2009-2014   子课题主持人,癌细胞微环境中蛋白质因子的功能与调控, 中国科技部“973”项目。
                          2.2009-2010   主持人,构建高瘦肉率、高肌间脂肪含量和高生殖力的转基因猪,  中国农业部转基因专项项目。
                          3.2010-2013 主持人,PEPCK-C转基因小鼠对高脂肪食物诱发的肥胖和糖尿病的抵抗及可能机制,国家自然科学基金

代表论著 (*为通讯作者):
                          1.Dong Wei, Jie Li, Miaoda Shen, Wei Jia, Nuoqi Chen, Tao Chen, Dongming Su, Haoming Tian, Shu-Sen  Zheng, Yifan Dai, and Allan Zhao*,Cellular Production of ω-3 PUFAs and Reduction of ω-6/ω-3 Ratios in the Pancreatic bβ-cells and Islets Enhance Insulin Secretion and Confer Protection against Cytokine-induced Cell Death. Diabetes,59(2), 471-478, 2010.
                          2.Kyu Lim, Chang Han, Yifan Dai, Miaoda Shen and Tong Wu*, Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through downregulation of Wnt/-catenin and COX-2 signaling pathways. Mol. Cancer Ther. 8(11), 3046-3055, 2009.
                          3.Yi Lu, Daibang Nie, William T. Witt, Qiuyan Chen, Miaoda Shen, Haiyang Xie, Liangxue Lai, Yifan Dai*, Jian Zhang*, Expression of Fat-1 gene diminishes prostate cancer growth through concurrent Wnt/β-catenin-DKK1 and PI3K/AKT signaling pathways.Mol. Cancer Ther. 7(10), 3203-3211, 2008.
                          4.Liangxue Lai, Jing X. Kang, Rongfeng Li, Jingdong Wang, William T. Witt, Hwan Yul Yong, Yanhong Hao, David M. Wax, Clifton N. Murphy, August Rieke, Melissa Samuel, Michael L. Linville, Scott W. Korte, Rhobert W. Evans, Thomas E. Starzl, Randall S. Prather*, Yifan Dai*, Generation of Cloned Transgenic Pigs Rich in Omega-3 Fatty Acids.Nature Biotechnology, 24(4): 435-436, 2006.
                          5.Gang Chen, Hua Qian, Thomas Starzl*, Hongtao Sun, Bertha Garcia, Ximo Wang, Yishai Wise, Yuanqing Liu, Ying Xiang, Laura Copeman, Weihua Liu, Anthony Jevnikar, William Wall, David K C Cooper, Noriko Murase, Yifan Dai, Wanyu Wang, Yuliang Xiong, David J. White and Robert Zhong*, Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys.Nature Medicine, 11(12):1295-1298, 2005.
                          6.Carol J. Phelps, Chihiro Koike, Todd D. Vaught, Jeremy Boone, Kevin D. Wells, Shu-Hung Chen, Suyapa Ball, Susan M. Specht, Irina A. Polejaeva, Jeff A. Monahan, Pete M. Jobst, Sugandha M. Sharma, Ashley E. Lamborn, Amy S. Garst, Marilyn Moore, Anthony J. Demetris, William A. Rudert, Rita Bottino, Suzanne Bertera, Massimo Trucco, Thomas E. Starzl, Yifan Dai*, David L. Ayares*, Production of a1,3-Galactosyltransferase Deficient Pigs.Science, 299, 411-414, 2003.
                          7.Yifan Dai*, Todd D. Vaught, Jeremy Boone, Shu-Hung Chen, Carol J. Phelps, Suyapa Ball, Jeff A. Monahan, Pete M. Jobst, Kenneth J. McCreath, Ashley E. Lamborn, Jamie L. Cowell-Lucero, Kevin D. Wells, Alan Colman, Irina A. Polejaeva, David L. Ayares., Targeted disruption of the 1,3-galactosyltransferase gene in cloned pigs.Nature Biotechnology, 20, 251-255, 2002. (杂志封面).
                          8.Irina Polejaeva*, Shu-hung Chen, Todd Vaught, Ray Page, June Mullins, Suyapa Ball, Yifan Dai, Jeremy Boone, Shawn Walker, David L. Ayares, Alan Colman and Keith H. S. Campbell, Cloned pigs produced by nuclear transfer from adult somatic cells. Nature, 407, 86-90, 2000 (杂志封面).
                          9.Yifan Dai, Edward M. Schwarz, Danling Gu, Wei-wei Zhang, Nora Sarvetnick and Inder M. Verma*, Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of both factor IX and vector antigens allows for long term expression. PNAS,92(4), 1401-1405, 1995. (Hot paper in 1995)
                          10.Yifan Dai, Mark Roman, Robert K. Naviaux & Inder M. Verma*, Gene therapy via primary myoblasts:  Long term expression of factor IX protein following transplantation in vivoPNAS, 89 (22), 10892-10895, 1992.

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