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周洪 免疫学


发布时间: 2015-05-28 访问次数: 3892

周洪,博士,江苏特聘教授,博士生导师



    基础医学院副院长




研究方向:炎症,免疫应答和细胞迁移




地址:南京市汉中路140号免疫学系



邮编:210029



电话:025-86869453



E-mail:hzhou@njmu.edu.cn




     周洪,男,博士,教授,江苏省特聘教授,南京医科大学基础医学院副院长,免疫学系主任,中国免疫学会青年工作委员会委员,J. Immunol.J. Neuroimmunol.等期刊审稿人。1996年研究生就读于上海第二医科大学,自2002年开始在北美多个研究机构一直从事炎症和细胞招募相关的科研工作,曾获得加拿大健康研究所奖学金。工作主要揭示了小胶质细胞在脑部炎症状态下激活并介导免疫细胞招募和内皮细胞在系统性炎症中通过TLR4直接识别病原的具体机制。201011月回国工作,现主持国家自然科学基金,教育部博士点基金等多项科研项目。

荣誉奖励:

2013年江苏省第五期“333高层次人才培养工程第三层次培养对象

2012年江苏省特聘教授

2008 Hotchkiss脑研究所多发性硬化博士后奖学金

2005年加拿大健康研究所(CIHR)博士后奖学金

研究基金和课题:

1.活体显微镜技术研究CXC趋化因子在CNS炎症中招募中性粒细胞的机制,国家自然科学基金,60万,2012-2015

2.补体成分C3C5介导中枢神经系统炎症中血管内皮激活和中性粒细胞招募,国家自然科学基金(81373225),70万,2014-2018(主持)

3.中枢神经系统炎症状态下补体C3C5对中性粒细胞招募的影响,教育部高等学校博士学科点专项科研基金(博导类20133234110005),12万,2014-2017(主持)

4.环境内分泌干扰物对女性生殖功能的影响及其分子机制,国家科技部重大科学研究计划(973)项目(2014CB943303),70万,2014-2019(研究骨干)

代表性成果:

  1. Wu F, Zhao Y,Jiao T, Shi D, Zhu X, Zhang M, Shi M, Zhou H. CXCR2 is essential for cerebralendothelial activation and leukocyte recruitment during neuroinflammation. JNeuroinflammation. 2015 May 21; 12(1): 98. doi: 10.1186/ s12974-015-0316-6.

  2. Liu G, Sun D,Wu H, Zhang M, Huan H, Xu J, Zhang X, Zhou H, Shi M. Trypanosoma bruceiinfections: distinct contributions of CD4+ and CD8+ T cells to the pathogenesisin the context of IFN-γ and IL-10. Infect Immun. 2015 Apr 27. pii:IAI.00357-15. [Epub ahead of print]

  3. Moriarty,T.J., Shi M, Lin YP, Ebady R., Zhou H, Benoit V., Wu J., Hardy P.O., Salman A.D., Kubes P., Skare J.T., Leong J.M., Chaconas G. Vascular binding of apathogen under shear force through mechanistically distinct sequentialinteractions with host macromolecules. Mol Microbiol. 2012, 86:1116-1131.

  4. Chi J, Hu WX,Gu B, Zhang C, Peng GY, Zhou F, Chen Y, Zhang GF, Guo YD, Guo D, Qin J, WangJF, Li LL, Wang F, Liu G, Xie F, Feng DJ, Zhou H, Huang X, Lu S, Yao K Humanherpesvirus 6 latent infection in glioma patients. J Infect Dis. 2012,206:1394-1398.

  5. Langer HF,Choi EY, Zhou H, Schleicher R, Chung KJ, Tang Z, Göbel K, Bdeir K,Chatzigeorgiou A, Wong C, Bhatia S, Kruhlak MJ, Rose JW, Burns JB, Hill KE, QuH, Zhang Y, Lehrmann E, Becker KG, Wang Y, Simon DI, Nieswandt B, Lambris JD,Li X, Meuth SG, Kubes P, Chavakis T. Platelets contribute to the pathogenesisof experimental autoimmune encephalomyelitis. Circ Res. 2012110:1202-1210.

  6. Shi M, Li S,Zheng C, Jones GJ, Zhou H, Kubes P, Mody CH Real-time imaging of trapping andureasedependent transmigration of Cryptococcus neoformans in mouse brain. JClin. Invest. 2010, 120: 1683-1693.

  7. Lee WY,Moriarty TJ, Wong CH, Zhou H, Chaconas G, Strieter R, Kubes P An intravascularimmune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells. NatImmunol. 2010, 11:295-302.

  8. Zhou H,Andonegui G, Wong CH, Kubes P Role of endothelial TLR4 for neutrophilrecruitment into central nervous system microvessels in systemic inflammation. JImmunol. 2009, 183: 5244-5250.

  9. Andonegui G*,Zhou H*, Bullard D, Kelly M, MacDonald B, Mullaly S, Long E, Robbins S, Kubes PMice that exclusively express TLR4 on endothelial cells can efficiently clear alethal systemic Gram-negative bacterial infection. J Clin Invest. 2009,119: 1921-1930. Research highlighted in Nat Rev Immunol. Aug. 2009, 9:532 (Co-firstauthors equally contributed to the work)

  10. Menezes G, Lee WY, Zhou H, Waterhouse C,Cara D, Kubes P Selective down-regulation of neutrophil Mac-1 in endotoxemichepatic microcirculation via IL-10. J Immunol. 2009, 183: 7557–7568.

  11. Audoy JR, Soulet D, Zhou H, Kubes P,Vallières L Rod-shaped monocytes patrol the brain vasculature and give rise toperivascular macrophages under the influence of pro- inflammatory cytokines andangiopoietin-2. J Neurosci. 2008, 28: 10187-10199.

  12. Zhou H, Jiao Z, Pan J, Hong J, Tao J, Li N,Zhou Y, Zhang J, Zhou GY. Immune suppression via IL-4/IL-10-secreting T cells:A nontoxic property of anti-HIV agent trichosanthin. Clin Immunol. 2007,122: 312-322.

  13. Zhou H, Lapointe BM, Clark SR, Kubes P. Arequirement for microglial TLR4 in leukocyte recruitment into brain in responseto LPS. J Immunol. 2006, 177:8103-8110.

  14. Cao Y, Zhou H, Tao J, Zheng Z, Li N, ShenB, Shih TS, Hong J, Zhang J, Zhou GY.Keratinocytes induce local tolerance toskin graft by activating IL-10-secreting T cells in the context ofcostimulation molecule B7-H1. Transplantation 2003, 75: 1390-1396.


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