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肖明


发布时间: 2016-02-25 访问次数: 3265
 

肖明,博士,教授,博士生导师

 
    
  研究方向:神经退行性疾病  
 
 
 
 

地址:南京市江宁区龙眠大道101号

 
 

邮编:210029

 
 

电话:025-86869218

 
 

E-mail:mingx@njmu.edu.cn

 

   

肖明,博士, 197211月出生,现任南京医科大学江苏省神经退行性疾病重点实验室研究员,博士生导师;兼任南京医科大学科学技术处副处长;南京医科大学基础医学院青年(教师)联谊会主席;江苏解剖学会秘书长;中国解剖学会和美国神经科学会会员。1995年本科毕业于南京医科大学临床医学系;2001硕士研究生毕业于南京医科大学人体解剖学与组织胚胎学专业,获硕士学位;2005年博士研究生毕业于南京医科大学药理学专业,获博士学位。2002-2005年在美国路易斯维尔大学医学院研修。担任Neurobiology of Disease, Neuroscience, Europe Journal of Neuroscience, RejuvenationResearch等近30SCI期刊审稿专家;Aging and NeurodegenerationInternational Journal of Clinical and Experimental NeurologyInternational Journal of Behavioral Research & PsychologyTherapeutic Targets for Neurological DiseasesAustin Journal of Anatomy编委;荷兰NIH重点项目评审专家。
主要研究方向为神经退行性疾病和脑衰老的基础研究。近5年来,主持国家自然基金面上项目2项,以通讯作者身份发表SCI论文20余篇。

主持或参加科研项目及人才计划项目:

1.国家自然科学基金面上项目,水通道蛋白-4在阿尔茨海默病进程中的作用及机制(81271210),起止日期:2013/01-2016/12,主持。

2.国家自然科学基金面上项目,水通道蛋白-4对星形胶质细胞功能的调节及其与阿尔茨海默病的相关性研究(30971020),起止日期:2010/01-2012/12,主持。

3.国家自然科学基金重点项目,甲状旁腺素相关肽核定位序列和C末端在抗衰老中的作用机制研究(30830103),起止日期:2009/01-2012/12,参与人(2/9)。

4.江苏省普通高校青蓝工程中青年学术带头人基金项目,起止日期:2012/12- 2015/12。

近5年来发表通讯作者论文:

1. Xu ZQ, Huang H, Chen YL, Gao YY, Xu J, Marshall C, Cai ZY, Xiao M*. Different expression patterns of amyloid-β protein precursor secretases in human and mouse hippocampal neurons: A potential contribution to species differences in neuronal susceptibility to amyloid-β pathogenesis. J Alzheimers Dis. 2016 Jan 20. [Epub ahead of print] PubMed PMID: 26836155.

2.Chen YL, Wang LM, Chen Y, Gao JY, Marshall C, Cai ZY, Hu G, Xiao M*. Changes in astrocyte functional markers and β-amyloid metabolism-related proteins in the early stages of hypercholesterolemia. Neuroscience. 2016 Mar 1;316:178-91.

3. Xu Z, Xiao N, Chen Y, Huang H, Marshall C, Gao J, Cai Z, Wu T, Hu G, Xiao M*. Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits. Mol Neurodegener. 2015 Nov 2;10:58.

4. Huang H, Wang L, Cao M, Marshall C, Gao J, Xiao N, Hu G, Xiao M*. Isolation Housing Exacerbates Alzheimer's Disease-Like Pathophysiology in Aged APP/PS1 Mice. Int J Neuropsychopharmacol. 2015 Jan 7;18(7):pyu116.

5. Yuan C, Gao J, Guo J, Bai L, Marshall C, Cai Z, Wang L, Xiao M*. Dimethyl sulfoxide damages mitochondrial integrity and membrane potential in cultured astrocytes. PLoS One. 2014 Sep 19;9(9):e107447.

6. Hao L, Huang H, Gao J, Marshall C, Chen Y, Xiao M*. The influence of gender, age and treatment time on brain oxidative stress and memory impairment induced by D-galactose in mice. Neurosci Lett. 2014 Jun 13;571:45-9.

7. Xiao M*, Hu G. Involvement of aquaporin 4 in astrocyte function and neuropsychiatric disorders. CNS Neurosci Ther. 2014 May;20(5):385-90.

8. Wu Q, Zhang YJ, Gao JY, Li XM, Kong H, Zhang YP, Xiao M*, Shields CB, Hu G. Aquaporin-4 mitigates retrograde degeneration of rubrospinal neurons by facilitating edema clearance and glial scar formation after spinal cord injury in mice. Mol Neurobiol. 2014 Jun;49(3):1327-37.

9. Xu ZQ, Zhang LQ, Wang Q, Marshall C, Xiao N, Gao JY, Wu T, Ding J, Hu G, Xiao M*. Aerobic exercise combined with antioxidative treatment does not counteract moderate- or mid-stage Alzheimer-like pathophysiology of APP/PS1 mice. CNS Neurosci Ther. 2013 Oct;19(10):795-803.

10. Gu M, Shen L, Bai L, Gao J, Marshall C, Wu T, Ding J, Miao D#, Xiao M#. Heterozygous knockout of the Bmi-1 gene causes an early onset of phenotypes associated with brain aging. Age (Dordr). 2014 Feb;36(1):129-39.

11. Liu XL, Lu YS, Gao JY, Marshall C, Xiao M*, Miao DS, Karaplis A, Goltzman D, Ding J. Calcium sensing receptor absence delays postnatal brain development via direct and indirect mechanisms. Mol Neurobiol. 2013 Dec;48(3):590-600.

12. Li X, Gao J, Ding J, Hu G, Xiao M*. Aquaporin-4 expression contributes to decreases in brain water content during mouse postnatal development. Brain Res Bull. 2013 May;94:49-55.

13. Wei S, Xu Z, Gao J, Ding J, Xiao M*. Prenatal ethanol exposure does not causeneurological alterations in adult CD1 mice. Neuroreport. 2013 Mar 6;24(4):196-201.

14. Gao J, Tan M, Gu M, Marshall C, Ding J, Hu G, Xiao M*. Cellular localization of aquaporin-1 in the human and mouse trigeminal systems. PLoS One. 2012;7(9):e46379.

15. Li L, Xiao N, Yang X, Gao J, Ding J, Wang T, Hu G, Xiao M*. A high cholesterol diet ameliorates hippocampus-related cognitive and pathological deficits in ovariectomized mice. Behav Brain Res. 2012 Apr 21;230(1):251-8.

16. Yang W, Wu Q, Yuan C, Gao J, Xiao M*, Gu M, Ding J, Hu G. Aquaporin-4 mediates astrocyte response to β-amyloid. Mol Cell Neurosci. 2012 Apr;49(4):406-14.

17. Cao G, Gu M, Zhu M, Gao J, Yin Y, Marshall C, Xiao M*, Ding J, Miao D. Bmi-1 absence causes premature brain degeneration. PLoS One. 2012;7(2):e32015.

18. Liu L, Lu Y, Kong H, Li L, Marshall C, Xiao M*, Ding J, Gao J, Hu G. Aquaporin-4 deficiency exacerbates brain oxidative damage and memory deficits induced by long-term ovarian hormone deprivation and D-galactose injection. Int J Neuropsychopharmacol. 2012 Feb;15(1):55-68.

19. Wu W, Li M, Liu L, Gao J, Kong H, Ding J, Hu G, Xiao M*. Astrocyte activation but not neuronal impairment occurs in the hippocampus of mice after 2 weeks of d-galactose exposure. Life Sci. 2011 Sep 12;89(11-12):355-63.

20. Li L, Ding J, Marshall C, Gao J, Hu G, Xiao M*. Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus D-galactose-injected mice. Behav Brain Res. 2011 Feb 2;217(1):244-7.

 

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