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杨硕                                  免疫学


发布时间: 2015-11-30 访问次数: 4312


杨硕,博士,特聘教授,博士生导师





研究方向:炎症性疾病的分子调控






地址:南京市汉中路140号免疫学系



邮编:210029



电话:025-86869453



E-mail:hashuoy@gmail.com



  杨硕,男,博士,教授。2007年博士研究生毕业于中科院上海分院生物化学和细胞生物学研究所细胞生物学和神经生物学专业。工作主要揭示了影响肠道炎症疾病和代谢炎症疾病的重要免疫分子事件。现主持国家自然科学基等多项科研项目。

荣誉奖励:
 2008年  中国科学院优秀毕业生“地奥”奖一等奖
  2005年  中科院优秀学生奖学金

研究基金和人才计划:
  1.炎症小体对肠道炎症调节功能的研究,国家自然科学基金(81570499),68万,2015-2019 (主持)

代表性成果:
  1. Yang, S.*, Wang, B.*, Humphries, F., Hogan, A.E., O’Shea, D., Moynagh, P.N. The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance (2014) Immunity Available online 29 November 2014; doi:10.1016/j.immuni.2014.11.013 (* Co-first authors)
  2. Humphries, F., Yang, S., Wang, B., Moynagh, P.N. RIP kinases: key decision makers in cell death and innate immunity (2014) Cell Death Differ doi: 10.1038/cdd.2014.126
  3. Yang, S., Wang, B., Tang, L.S., Siednienko, J., Callanan, J.J., Moynagh, P.N. Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α. (2013) Nature Communications 4:2583; doi: 10.1038/ncomms3583
  4. Yang, S., Wang, B., Humphries, F., Jackson, R., Healy, M.E., Bergin, R., Aviello, G., Hall, B., McNamara, D., Darby, T., Quinlan, A., Shanahan, F., Melgar, S., Fallon, P.G., Moynagh, P.N. Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis (2013) Nature Immunology 14(9) PP.927–936; doi: 10.1038/ni.2669 
  5. Siednienko, J., Jackson, R., Mellett, M., Delagic, N., Yang, S., Wang, B., Tang, L.S., Callanan, J.J., Moynagh, P.N. Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3-and viral-induced expression of type I interferons (2012) Nature Immunology 13 (11) PP.1055–1062; doi: 10.1038/ni.2429
  6. Siednienko, J., Maratha, A., Yang, S., Mitkiewicz, M., Miggin, S.M., Moynagh, P.N. Nuclear factor κB subunits RelB and cRel negatively regulate toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1 (2011) Journal of Biological Chemistry 286(52) PP.44750–44763; doi: 10.1074/jbc.M111.250894
  7. Wang, H., Xiao, W., Zhou, Q., Chen, Y., Yang, S., Sheng, J., Yin, Y., Fan, J., Zhou, J. Bystin-like protein is upregulated in hepatocellular carcinoma and required for nucleologenesis in cancer cell proliferation (2009) Cell Research 19(10) PP.1150–1164; doi: 10.1038/cr.2009.99
  8. Yang, S., Liu, X., Yin, Y., Fukuda, M.N., Zhou, J. Tastin is required for bipolar spindle assembly and centrosome integrity during mitosis (2008) FASEB Journal 22(6) PP.1960–1972; doi: 10.1096/fj.07-081463
  9. Li, A., Guo, H., Luo, X., Sheng, J., Yang, S., Yin, Y., Zhou, J., Zhou, J. Apomorphine-induced activation of dopamine receptors modulates FGF-2 expression in astrocytic cultures and promotes survival of dopaminergic neurons (2006) FASEB Journal 20(8) PP.1263-1265; doi: 10.1096/fj.05-5510fje
  10. Ma, L., Yin, M., Wu, X., Wu, C., Yang, S., Sheng, J., Ni, H., Fukuda, M.N., Zhou, J. Expression of trophinin and bystin identifies distinct cell types in the germinal zones of adult rat brain (2006) European Journal of Neuroscience 23(9) PP. 2265-2276; doi: 10.1111/j.1460-9568.2006.04782.x
  11. Sheng, J., Yang, S., Xu, L., Wu, C., Wu, X., Li, A., Yu, Y., Ni H, Fukuda, M.N., Zhou, J. Bystin as a novel marker for reactive astrocytes in the adult rat brain following injury (2004) European Journal of Neuroscience 20(4) PP.873-884; doi: 10.1111/j.1460-9568.2004.03567.x

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