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刘星吟                               病原生物学


发布时间: 2016-03-18 访问次数: 2342

刘星吟,博士,教授,博士生导师,南京医科大学特聘教授

研究方向:

1.病原微生物以及其他环境因素对宿主信号转导和表观遗传学研究;
2.肠道微生物与人类疾病;

联系电话:025-86869397  

地址:南京市汉中路140号病原生物学系

 邮编:210029

     刘星吟,女,南京医科大学教授,博士生导师。 2006年获得中山大学理学博士学位, 2006年至2010年,先后在美国Rochester大学生物系和医学院从事表观遗传学和肠道病原微生物与宿主相互作用的信号转到机制的研究。2010-2015 在美国爱因斯坦医学院从事表观遗传学研究。现为美国遗传学会员。是Veterinary Microbiology, Molecular Biology Reports, Medical oncology, BioMed Research International, International Journal of Biological Sciences Mediators of InflammationRNA biologySCI收录杂志审稿人。在 Cell Reports, PLOS Genetics, Inflammation Bowel Disease, American Journal of PhysiologyBMC Genomics等国际权威期刊上发表SCI论文多篇. 2015.7月作为高层次引进人才受聘于南京医科大学病原生物系。

代表性论文

第一作者文章:

1.  Xingyin Liu and Julie Secombe(2015), The histone demethylase KDM5 activates gene expression by recognizing chromatin context through its PHD reader motif. Cell Reports, 13(10): 2219-31.

2.  Xingyin Liu Christina Greer Julie Secombe (2014), KDM5 interacts with Foxo to modulate/affect cellular levels of oxidative stress, PLOS Genetics, 10.1371/ journal.pgen.1004676.

3. Xingyin LiuRong Lu, Shaoping Wu , Yinglinxia , Yong-guo Zhang R. Balfour Sartor and  Jun  Sun  (2012) Wnt2  inhibits  enteric  bacterial-induced  inflammation  in  intestinal epithelial cells. Inflamm Bowel Dis 18(3):418-29.

4.  Xingyin Liu,Shaoping Wu Yinglin Xia, Xi Emma Li and Jun Sun (2011) Wingless homolog Wnt 11 suppresses bacterial invasion and inflammation in intestinalepithelial cells American Journal of Physiology - Gastrointestinal and Liver Physiology301(6):G992-G1003.

5.  Xingyin  Liu Rong  Lu,  Shaoping Wu  and  Jun  Sun  (2010)  Global  analysis  of  the eukaryotic  pathways  and  networks  regulated  by  Salmonella  typhimurium  in  mouse intestinal infection in vivo. BMC Genomics. 11:722-748. (Highly accessed)

6.  Xingyin Liu,Rong Lu, Shaoping Wu and Jun Sun (2010) Salmonella regulation of intestinal stem cells through the Wnt/beta-catenin pathway, FEBS Lett. 584(5):911-916. (Cover paper)

7.  Xingyin  Liu,Rong  Lu,  Yinglinxia  Wu  and  Jun  Sun  (2010)  Eukaryotic  signaling pathways targeted by Salmonella effector protein AvrA in intestinal infection in vivo BMC Microbiol. 10:326-344(Highly accessed)

8. Xing-Yin Liu,, Kam-Len Daniel Lee, Yong-Zhen Mao and Li-Pei Jin (2006). Isolation, characterization and phylogeneticanalysisof the cytochrome b gene (cyb) from the hypotrichous ciliate PseudourostylacristataActa Protozoologica .ActaProtozool. 45: 241  248.

9. Xing-Yin Liu, Kam-Len Daniel Lee, Yong-Zhen Mao, Tao Liu and Li-Pei Jin (2005) Differential gene expression during stationary phase between amicronucleates and micronucleates of the Ciliated ProtistPseudourostyla- cristata. Current genetics 48(6):401-11.

共同通讯文章:

10. Hui-chan He, Zhao-dong Han, Qi-shan Dai, Xiao-hui Ling, Xin Fu, Zhuo-yuan Lin, Ye-han Deng, Guo-qiang Qin, Chao Cai, Jia-hong Chen, Fu-neng Jiang, Xingyin Liu(co-coressponding author), Wei-de Zhong(2013)Global analysis of the differentially expressed miRNAs of prostate cancer in Chinese patients. BMC Genomics, 14:757. 10.1186/1471-2164-14-757.

11. Jia-hong Chen, Hui-chan He, Fu-nengJiangJuliaMilitar, Petor-yang Ran, Guo-qiang Qin, Chao Cai, Xi-bin Chen, Jin Zhao, Zi-yao Mo, Yan-ru Chen, Jian-guo Zhu,  Xingyin Liu (co-coressponding author)and Wei-de Zhong, Analysis of the specific pathways and networks of prostate cancer for gene expression profiles in the Chinese Population. (2012) Medical Oncolgoy, 29(3):1972-84.

其它文章:

12. Jing Xu, Huaru Tian, Xingyin Liu, Wei Wang andAihua Liang (2013) Localization and functional analysis of HmgB3p, a novel protein containing high mobility-group-box domain from Tetrahymena thermophile Gene,10;526(2):87-95

13.  Rong Lu, Shaoping Wu, Yong-guo Zhang, Yinglin Xia,  Xingyin Liu, , David Zhou, Liheng Li, Bruce Marc Bissonnette, Jun Sun (2014) Enteric bacterial protein AvrA enhances tumorigenesis through activating intestinal beta-catenin signaling pathways, Oncogenesis, 93(4):882-90. doi: 10.3382/ps.2013-03723.

14. Rong Lu, Xingyin Liu, Shaoping Wu,  Yinglin Xia, Yong-guo Zhang, Elaine O Petrof, Erika C Claud, Jun Sun (2012) Consistent activation of the beta-catenin pathway by the bacterial type-three-secretion effector protein AvrA in chronic infected mice, American Journal of Physiology - Gastrointestinal and Liver Physiology. 15;303(10):G1113-2.

15.Shaoping Wu, Yinglin Xia, Xingyin Liu, and Jun Sun ( 2010). Vitamin D receptor deletion leads to reduction of the total IkappaBalpha protein. International Journal of Biochemistry & Cell Biology 42(2):329-336

16.Shaoping Wu, Zhongde Ye, XingyinLiu , Yun Zhao, Yinglin Xia, Andrew Steiner,Elaine O. Petrof, Erika C. Claud, Jun Sun (2010), Salmonella typhimurium infection increases intestinal p53 acetylation in intestinal epithelial cells. Am J PhysiolGastrointest Liver Physiol. 298(5):G784-94.

17.Rong Lu, Shaoping Wu, Xingyin Liu, Yinglin Xia and Jun Sun (2010) Chronic effects of a Salmonella type-three-secretion effector protein AvrAin vivo. PLOS ONE 5;5(5):e10505.

18. Hongfang Liu, Liyan Xi, Junmin Zhang, Xiqing Li, Xingyin Liu,Changming Lu, Jiufeng Sun , 2007. Identifying differentially expressed genes in the dimorphic fungus Penicilliummarneffei by suppression subtractive hybridization FEMS Microbiol Lett. 270(1):97-103.

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