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张志远                               病理学


发布时间: 2015-11-27 访问次数: 1860

张志远博士,教授

研究方向:神经系统病理和免疫病理

地址:南京市汉中路140号病理学系

邮编:210029

电话:025-86869333

E-mail:zzy@njmu.edu.cn


  张志远,男,博士,教授。2001毕业于于南京医科大学,获医学学士学位。2009德国图宾根大学获得生物医学与神经科博士。2009-2011年在图宾根大学医学院从事博士后研究工作,重点为神经系统的病理及免疫病理相关的临床诊断和基础研究。2011-2015年进而在图宾根大学神经病理研究所获聘专职研究员,研究重点为神经系统的自身免疫病,外伤后继发损伤,退行性病变等。2015年起任南京医科大学病理学系教授。


  代表性成果:

1.Zhang ZY, Zhang Z, Artelt M, Burnet M, Schluesener HJ. Dexamethasone attenuates early expression of three molecules associated with microglia/macrophages activation following rat traumatic brain injury. Acta Neuropathol. 2007; 113(6):675-82.

2.Zhang ZY, Zhang Z, Fauser U, Artelt M, Burnet M, Schluesener HJ. FTY720 attenuates accumulation of EMAP-II+ and MHC-II+ monocytes in early lesions of rat traumatic brain injury. J Cell Mol Med. 2007; 11(2):307-314.

3.Zhang ZY, Zhang Z, Fauser U, Artelt M, Burnet M, Schluesener HJ. Dexamethasone transiently attenuates up-regulation of endostatin/collagen XVIII following traumatic brain injury. Neuroscience. 2007 Jul 13;147(3):720-6.

4.Zhang ZY, Zhang Z, Fauser U, Schluesener HJ. Global hypomethylation defines a sub-population of reactive microglia/macrophages in experimental traumatic brain injury. Neurosci Lett. 2007 Dec 11;429(1):1-6.

5.Zhang Z, Zhang ZY, Schluesener HJ. (equally contributed first author) In vivo and in vitro differences between leukocytic uptake of oligodeoxynucleotides. Cell Mol Life Sci. 2008 Apr;65(7-8):1237-47.

6.Zhang Z, Burger K, Hellwig S, Bergemann J. A UVB fingerprint mutation on the p53 tumor suppressor gene decreases in vitro. Cells Tissues Organs. 2008;188(3):280-6.

7.Zhang Z, Zhang ZY, Fauser U, Schluesener HJ. (equally contributed first author) Valproic acid attenuates inflammation in experimental autoimmune neuritis. Cell Mol Life Sci. 2008 Dec;65(24):4055-65.

8.Zhang Z, Zhang ZY, Fauser U, Schluesener HJ. (equally contributed first author) FTY720 ameliorates experimental autoimmune neuritis by inhibition of lymphocyte and monocyte infiltration into peripheral nerves. Exp Neurol. 2008 Apr;210(2):681-90.

9.Zhang ZY, Zhang Z, Fauser U, Schluesener HJ. Improved outcome of EAN, an animal model of GBS, through amelioration of peripheral and central inflammation by minocycline. J Cell Mol Med. 2009 Feb;13(2):341-51.

10.Zhang Z, Zhang ZY, Fauser U, Schluesener HJ. Distribution of Foxp3(+) T-regulatory cells in experimental autoimmune neuritis rats. Exp Neurol. 2009 Mar;216(1):75-82.

11.Zhang ZY, Zhang Z, Schluesener HJ. Toll-like receptor-2, CD14 and heat-shock protein 70 in inflammatory lesions of rat experimental autoimmune neuritis. Neuroscience. 2009 Mar 3;159(1):136-42.

12.Zhang ZY, Zhang Z, Zug C, Nuesslein-Hildesheim B, Leppert D, Schluesener HJ. AUY954, a selective S1P(1) modulator, prevents experimental autoimmune neuritis. J Neuroimmunol. 2009 Nov 30;216(1-2):59-65.

13.Zhang ZY, Zhang Z, Schluesener HJ. FTY720 attenuates lesional interleukin-17(+) cell accumulation in rat experimental autoimmune neuritis. Neuropathol Appl Neurobiol. 2009 Oct;35(5):487-95.

14.Zhang Z, Zhang ZY, Schluesener HJ. (equally contributed first author) Compound A, a plant origin ligand of glucocorticoid receptors, increases regulatory T cells and M2 macrophages to attenuate experimental autoimmune neuritis with reduced side effects. J Immunol. 2009 Sep 1;183(5):3081-91.

15.Zhang ZY, Zhang Z, Fauser U, Schluesener HJ. Expression of interleukin-16 in sciatic nerves, spinal roots and spinal cords of experimental autoimmune neuritis rats. Brain Pathol. 2009 Apr;19(2):205-13.

16.Zhang ZY, Zhang Z, Schluesener HJ. MS-275, an histone deacetylase inhibitor, reduces the inflammatory reaction in rat experimental autoimmune neuritis. Neuroscience. 2010 Aug 11;169(1):370-7.

17.Zhang ZY, Zug C, Schluesener HJ. (corresponding author) Sphingosine 1-phosphate receptor modulator FTY720 suppresses rat experimental autoimmune prostatitis. Scand J Immunol. 2011 Jun;73(6):546-53.

18.Zhang ZY, Schluesener HJ, Zhang Z. (corresponding author) Distinct expression of Tim-3 during different stages of rat experimental autoimmune neuritis. Brain Res Bull. 2011 Oct 10;86(3-4):229-34.

19.Zhang ZY, Schluesener HJ.(corresponding author) HDAC inhibitor MS-275 attenuates the inflammatory reaction in rat experimental autoimmune prostatitis. Prostate. 2012 Jan;72(1):90-9.

20.Zhang ZY, Schluesener HJ. (corresponding author) Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model. J Neuropathol Exp Neurol. 2013 Mar;72(3):178-85.

21.Zhang ZY, Daniels R, Schluesener HJ. (corresponding author) Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis. J Cell Mol Med. 2013 Dec;17(12):1566-76.

22.Liao Y, Liu P, Guo F, Zhang ZY, Zhang Z. (corresponding author) Oxidative burst of circulating neutrophils following traumatic brain injury in human. PLoS One. 2013 Jul 24;8(7):e68963.

23.Zhang ZY, Li C, Zug C, Schluesener HJ. (corresponding author) Icariin Ameliorates Neuropathological Changes, TGF-β1 Accumulation and Behavioral Deficits in a Mouse Model of Cerebral Amyloidosis. PLoS One. 2014 Aug 7;9(8):e104616.

24.Li C, Zug C, Qu H, Schluesener H, Zhang ZY.(corresponding author) Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice. Behav Brain Res. 2015 Mar 15;281:32-42

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